A5079233646- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Quantum, superfluid, helium dynamics
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Electron Spin Resonance Studies
- Ultrasound and Hyperthermia Applications
- Lanthanide and Transition Metal Complexes
- Virus-based gene therapy research
- Congenital Diaphragmatic Hernia Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Superconducting Materials and Applications
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Geophysical Methods and Applications
- Characterization and Applications of Magnetic Nanoparticles
- MRI in cancer diagnosis
- NMR spectroscopy and applications
- Adenosine and Purinergic Signaling
- Lung Cancer Diagnosis and Treatment
- Geomagnetism and Paleomagnetism Studies
Lawson Health Research Institute
2018-2025
Western University
2013-2025
St Joseph's Health Care
2023
Robarts Clinical Trials
2008-2016
Minnesota Oncology
2016
Lakehead University
2014
Thunder Bay Regional Research Institute
2013-2014
Rush University Medical Center
2013
Regional Cancer Center
2011
Yeshiva University
1983
To perform static breath-hold fluorine 19 ((19)F) three-dimensional (3D) ultrashort echo time (UTE) magnetic resonance (MR) imaging of the lungs in healthy volunteers by using a mixture 79% perfluoropropane (PFP) and 21% O2.This study protocol was approved local research ethics board Health Canada. All provided written informed consent. Ten underwent MR at 3.0 T. Fluorine 3D UTE images were acquired during 15-second breath hold according to one two breathing protocols: A, 1-L inhalation PFP...
Abstract A 19 Fluorine ( F) perfluorocarbon cell labeling agent, when employed with an appropriate cellular MRI protocol, allows for in vivo tracking. F can be used to non-invasively assess the location and persistence of cell-based cancer vaccines other therapies. This study was designed determine feasibility tracking peripheral blood mononuclear cells (PBMC), a heterogeneous population. Under GMP-compliant conditions human PBMC were labeled F-based cell-labeling agent manner safe...
Radiation-induced lung injury limits radiotherapy of thoracic cancers. Detection radiation pneumonitis associated with early radiation-induced (2–4 weeks postirradiation) may provide an opportunity to adjust treatment, before the onset acute and/or irreversible fibrosis. In this study, localized magnetic resonance (MR) spectroscopy and imaging hyperpolarized 13C-pyruvate (pyruvate) 13C-lactate (lactate) were performed in thorax kidney regions rats 2 following whole-thorax irradiation (14...
Purpose Inert fluorinated gas lung MRI is a new and promising alternative to hyperpolarized MRI; it less expensive does not require isotopes/polarizers. The thermally polarized nature of signal obtained from gases makes relatively easy use for dynamic imaging obtaining ventilation maps. In this study, we propose that the sensitivity resolution fluorine‐19 ( 19 F) in vivo images can be improved using x‐centric pulse sequence, thereby achieving short echo time/pulse repetition time. This study...
Radiation induced lung injury (RILI) is a common side effect for patients undergoing thoracic radiation therapy (RT). RILI can lead to temporary or permanent loss of function and in extreme cases, death. Combining functional imaging information with conventional treatment plans may more desirable that reduce toxicity improve the quality life cancer survivors. Magnetic Resonance Imaging following inhalation hyperpolarized(129)Xe provide useful nonionizing approach probing changes structure...
Purpose Radiation‐induced lung injury (RILI) is still the major dose‐limiting toxicity related to cancer radiation therapy, and it difficult predict detect patients who are at early risk of severe pneumonitis fibrosis. The goal this proof‐of‐concept preclinical demonstration was investigate potential hyperpolarized 129 Xe diffusion‐weighted MRI morphological changes associated with stage RILI. Methods Hyperpolarized performed using eight different diffusion sensitizations (0.0–115 s/cm 2 )...
Technetium-99m iminodiacetic acid (IDA) cholescintigraphy was performed in 15 patients with acute acalculous cholecystitis. Fourteen of the disease had positive findings, indicating presence cystic duct or common obstruction. One case which gallbladder visualized failed to respond sincalide stimulation; this classified as a suggestive finding disease. The diagnostic accuracy 99mTc-IDA far superior other imaging studies used (8 sonograms, 1 intravenous cholangiogram, 3 oral cholecystograms,...
Purpose Cellular MRI) was used to detect implanted human mesenchymal stem cells (hMSCs) and the resulting macrophage infiltration that occurs in response xenotransplantation. Methods Human were prelabeled with a fluorine-19 (19F) agent prior implantation, allowing for their visualization quantification over time. Following implantation of 1 × 106 19F-labeled hMSCs into mouse hind limb, longitudinal imaging performed monitor cell graft. Macrophages labeled situ by intravenous administration...
Stem cell-based therapies have demonstrated significant potential in clinical applications for many debilitating diseases. The ability to non-invasively and dynamically track the location viability of stem cells post administration could provide important information on individual patient response and/or side effects. Multi-modal cell tracking provides complementary that can offset limitations a single imaging modality yield more comprehensive picture fate. In this study, mesenchymal (MSCs)...
Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting translocator protein (TSPO) considered indicators neuroinflammation, but it is not clear how well expression TSPO coincides with major histocompatibility complex class II (MHCII) molecules WM. This aimed test ability detect activated WM microglia that immunohistochemically positive for MHCII rat models prodromal Alzheimer's...
The purpose of this study was to extend established methods for fractional ventilation mapping using 19 F MRI inert fluorinated gases rat models pulmonary inflammation and fibrosis. In study, five rats were instilled with lipopolysaccharide (LPS) in the lungs two days prior imaging, six bleomycin weeks imaging an additional four used as controls. MR lung performed at 3 T continuously breathing a mixture sulfur hexafluoride O 2 . Fractional maps obtained wash‐out approach, by switching pure ,...
Abstract Hyperpolarized Noble Gas (HNG), 3 He (helium) or 129 Xe (xenon), MR imaging has become a promising approach for visualizing lung anatomy and function. It been theoretically predicted that low field strengths (0.05–0.2 T) may provide optimal signal‐to‐noise ratio (SNR) spatial resolution clinical HNG imaging. These optimum correspond to frequencies between 1.62–6.5 MHz 0.59–2.35 respectively. The strength depends on the size geometry of sample radiofrequency (RF) coil as well...
Abstract Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer expressing specific antigens like human epidermal growth factor 2 (HER2). Despite their potential, CAR T exhibit variable response rates and adverse effects in some patients. Non-invasive molecular imaging can aid predicting patient outcomes by tracking infused post-administration. CAR-T are typically autologous, increasing manufacturing complexity costs. An alternative approach...
Purpose MRI using hyperpolarized noble gases, 3 He and 129 Xe, provides noninvasive assessments of lung structure function. Previous work demonstrated that absolute ventilated volumes (aVLV) measured in rats agree well with micro‐CT. Methods In this work, aVLV measurements were performed Xe compared under matched ventilation conditions. Whole‐lung compliance was also determined. Partial volume, apparent diffusion coefficient, effective transverse relaxation time corrections applied during...
Colorectal cancer is the third leading cause of death worldwide. 5-Fluorouracil (5-FU) one most commonly used chemotherapies for treatment solid tumours, including colorectal cancer. The efficacy dependent on tumour type and can only be determined six weeks after beginning chemotherapy, with 40-50% patients responding positively to 5-FU therapy. In this paper, we demonstrate potential using Magnetic Resonance (MR) Chemical Shift Imaging (CSI) in-vivo monitoring tumor-retention in two...