A5017297048- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Antibiotic Resistance in Bacteria
- Cancer Immunotherapy and Biomarkers
- Transgenic Plants and Applications
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Antimicrobial Peptides and Activities
- RNA and protein synthesis mechanisms
- Fibroblast Growth Factor Research
- Respiratory viral infections research
- Toxin Mechanisms and Immunotoxins
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
- Poxvirus research and outbreaks
- Peptidase Inhibition and Analysis
- Pneumonia and Respiratory Infections
- Lipid metabolism and disorders
- Actinomycetales infections and treatment
- MicroRNA in disease regulation
- Fungal Infections and Studies
- Viral Infections and Vectors
Xiangya Hospital Central South University
2022-2025
Central South University
2022-2025
Hunan Provincial Center for Disease Control and Prevention
2022-2025
Guangdong Pharmaceutical University
2025
National Clinical Research Center for Digestive Diseases
2025
Xuzhou Medical College
2023-2024
Alveolar epithelial cell damage is an important determinant of the severity acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, molecular mechanisms alveolar death during development ALI/ARDS remain unclear. In this study, we explore role miR-29a-3p in and its mechanism. Plasma samples were collected from healthy controls ARDS patients. Mice intratracheally instilled with lipopolysaccharide (LPS) to establish injury. N6-adenosine (m6A) quantification, RNA-binding...
Since May 2022, cases of monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), have been increasingly reported worldwide. There are, however, no proven therapies or vaccines available for monkeypox. In this study, several multi-epitope were designed against MPXV using immunoinformatics approaches.Three target proteins, A35R and B6R, enveloped virion (EV) form-derived antigens, H3L, expressed on mature (MV) form, selected epitope identification. The shortlisted epitopes fused...
Background Nocardia genus, a complex group of species classified to be aerobic actinomycete, can lead severe concurrent infection as well disseminated infection, typically in immunocompromised patients. With the expansion susceptible population, incidence has been gradually growing, accompanied by increased resistance pathogen existing therapeutics. However, there is no effective vaccine against this yet. In study, multi-epitope was designed using reverse vaccinology combined with...
Human metapneumovirus (HMPV) is one of the main pathogens causing severe respiratory infections in children, as a common cause immunodeficiency-related deaths children and elderly individuals, prevalence HMPV has been showing an increasing trend during last years. However, no vaccines or effective treatment plans are available currently. In this present, based on candidate proteins highly associated with viral virulence promising protective potential, we screened for immunodominant cytotoxic...
Acinetobacter baumannii, an opportunistic bacterium prevalent in various environment, is a significant cause of nosocomial infections ICUs. As the causative agent pneumonia, septicemia, and meningitis, A. baumannii typically exhibits multidrug resistance associated with poor prognosis, thus led to challenge for researchers developing new treatment prevention methods. This study involved development novel multi-epitope mRNA vaccine validation silico approaches was conducted. We screened 11...
Abstract Background The prevalence of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) is increasing worldwide. CRKP-BSI associated with high rates morbidity and mortality due to limited antibiotic choices. Here, we aim identify the risk factors for CRKP BSI. Methods This was a retrospective study past data from January 1st, 2012 December 31st, 2019 adult patients KP-BSI in Xiangya Hospital, China. Results Among 706 incidences included this study, 27.4% them...
Acinetobacter baumannii is a gram-negative bacillus prevalent in nature, capable of thriving under various environmental conditions. As an opportunistic pathogen, it frequently causes nosocomial infections such as urinary tract infections, bacteremia, and pneumonia, contributing to increased morbidity mortality clinical settings. Consequently, developing novel vaccines against utmost importance. In our study, we identified 10 highly conserved antigenic proteins from the NCBI UniProt...
Severe Fever with Thrombocytopenia Syndrome virus (SFTSV) is a novel identified pathogen, despite two decades of research on SFTSV, the potential widespread threats pose significant challenge for researchers in developing new treatment and prevention methods. In this present, we have developed multi-epitope mRNA vaccine SFTSV valid it silico We screened 9 immunodominant epitopes cytotoxic T cells (CTL), 7 helper (HTL), 8 Linear B-cell (LBL) based promising candidate protein Gn, Gc, Np, NSs....
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) and its related liver fibrosis represent a substantial public health burden with limited treatment options. Although MASH is associated enhanced neutrophil infiltration in the liver, mediators mechanisms underlying neutrophil-driven progression of remain largely unknown. This study aimed to investigate role serine proteases elastase (NE) proteinase 3 (PR3) development fibrosis. Approach: Liver biopsies from 121...
Targeting kinases presents a potential strategy for treating solid tumors; however, the therapeutic of vaccines targeting remains uncertain.
Pseudomonas aeruginosa is a typically opportunistic pathogen responsible for wide range of nosocomial infections. In this study, we designed two multi-epitope vaccines targeting P. proteins, incorporating cytotoxic T lymphocyte (CTL), helper (HTL), and linear B (LBL) epitopes identified using reverse vaccinology immunoinformatics approaches. The exhibited favorable physicochemical properties, including stability, solubility, optimal molecular weight, suggesting their potential as viable...
Clostridium difficile (C.difficile) is an exclusively anaerobic, spore-forming, and Gram-positive pathogen that the most common cause of nosocomial diarrhea becoming increasingly prevalent in community. Because C. strictly spores can survive for months external environment contribute to persistence diffusion within healthcare Antimicrobial therapy disrupts natural intestinal flora, allowing develop into propagules colonize colon produce toxins, thus leading antibiotic-associated...
Chikungunya virus (CHIKV), a type A borne by mosquitoes that can cause major clinical manifestations including rash, fever and debilitating arthritis, grown into reemerging serious public health issue. Currently, there is no licensed therapy or vaccine available for CHIKV, although the most promising form of treatment appears to be immunotherapy. Neutralizing antibodies CHIKV provide high protection all strains, as well other alphaviruses. Development protective may an effective strategy...
Immune-based checkpoint therapy has made significant progress in cancer treatment, but its therapeutic effect is limited. A replication-defective adenovirus (Ad) vaccine encoding tumor antigen carbonic anhydrase IX (CAIX) combined with Ad-encoding immune PD-L1 was developed to treat renal carcinoma. Three models, subcutaneous, lung metastasis and orthotopic were established, Ad vaccines used immunize them evaluate the vaccine's effect. Compared single group, subcutaneous growth significantly...
Staphylococcus aureus is an extraordinarily versatile pathogen, which currently the most common cause of nosocomial and community infections. Considering that increased antibiotic resistance may hasten spread S. aureus, developing effective vaccine can possibly aid in its control. The RNA coding immunodominance epitopes from bacteria provide a potential method to induce T B cell immune responses by translating them into cells. Furthermore, using bioinformatics create circular vaccines ensure...
Abstract Cryptococcus neoformans is a widely distributed opportunistic pathogenic fungus. While C. commonly infects immunocompromised individuals, it can also affect those who are immunocompetent. Transmission of primarily occurs through the respiratory tract, leading to development meningitis. The mortality rate Cryptococcal meningitis high, and treatment options limited. infections pose significant public health threat currently lack targeted effective response strategies. This study aimed...
Abstract Acinetobacter baumannii , a Gram-negative opportunistic pathogen that widely exists in the environment, causes numerous nosocomial infection cases ICU. As agent of pneumonia, septicemia, and meningitis, A. is usually multidrug-resistant has high mortality rate. In this study, we aimed to develop vaccine for through silico prediction. With help immunoinformatic methods, which have proven be effective convenient, our team managed multiepitope subunit vaccines . Three proteins closely...