Shenglin Duan

ORCID: 0009-0005-3067-9792
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Research Areas
  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • Food composition and properties
  • Diet, Metabolism, and Disease
  • Proteins in Food Systems
  • Diabetes Treatment and Management
  • Diet and metabolism studies
  • Dietary Effects on Health
  • Polysaccharides Composition and Applications
  • Microbial Metabolites in Food Biotechnology
  • Gut microbiota and health
  • Food Quality and Safety Studies
  • Muscle metabolism and nutrition
  • Enzyme Structure and Function
  • Microbial Natural Products and Biosynthesis
  • Fungal and yeast genetics research
  • Phytase and its Applications
  • Advanced Chemical Sensor Technologies
  • Meat and Animal Product Quality
  • Phytochemistry and biological activity of medicinal plants
  • Sensory Analysis and Statistical Methods
  • Exercise and Physiological Responses
  • Identification and Quantification in Food
  • High Altitude and Hypoxia
  • Analytical Chemistry and Chromatography

China National Research Institute of Food and Fermentation
2008-2025

General Administration of Quality Supervision, Inspection and Quarantine
2012

Abstract Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 Chinese volunteers with wide range of body mass index (BMI) participated in three-week IF program during an average 3.67 kg accompanied improved clinical parameters was observed irrespective initial anthropometric and status. Fecal samples were collected before after intervention subjected shotgun metagenomic De...

10.1038/s41522-023-00386-4 article EN cc-by npj Biofilms and Microbiomes 2023-04-07

Yeast wall polysaccharides (YWPs) are a bioactive compound found in the vegetative cells of Saccharomyces cerevisiae, contributing to its applications food and medicine. YWPs have been extensively studied because their diverse biological activities. Although yeast spore S. cerevisiae also contains polysaccharides, activities components spores received limited attention. In this study, (YSWPs) were extracted from chs3Δ with exposed β-glucan layers via an ultrasonic-assisted enzymatic...

10.1016/j.ultsonch.2025.107258 article EN cc-by Ultrasonics Sonochemistry 2025-02-08

The significant demand for medicinal plants with special efficacy has prompted us to adopt appropriate processing methods enhance the nutritional quality and flavor of raw materials. This study evaluated impacts freeze-drying (FD), hot-air drying (HAD), spray (SD) on bioactive compounds, characteristics, inhibition starch digestion in mulberry leaf ethanol extract (MLE). Results indicated that FDMLE exhibited highest total alkaloids content (TAC: 0.14 ± 0.02 mg/g) flavonoid (TFC: 19.32 0.58...

10.3390/foods14060998 article EN cc-by Foods 2025-03-14

This study evaluated the stability of casein phosphopeptides (CPP) and obtained peptide–calcium complex by heating chelating peptide with CaCl2 in a neutral solution. To assess bioavailability various calcium formulations, transport models were established Caco-2 cells, transcellular pathways formulations studied RT-PCR Western blotting. Results circular dichroism showed that CPP was stable polypeptide. The ultraviolet absorption spectrum Fourier transform-infrared (FT-IR) indicated could be...

10.1111/jfbc.14001 article EN Journal of Food Biochemistry 2021-11-08

Maca (Lepidium meyenii Walp.), originated in the high Andes of Peru, is rich nutrients and phytochemicals. As a new resource food China, suffers marketing disorders due to limitation basic research. Due close relationship quality origin place, it's scientific, economic social importance set up rapid, reliable efficient method identify origin. In present study, 303 samples were collected from 101 villages main producing area China. Using electronic nose BP neutral network algorithm, odor...

10.1038/s41598-019-47571-0 article EN cc-by Scientific Reports 2019-08-21

Abstract This work focused on the separation of active ingredients maca ( Lepidium meyenii Walpers) and evaluated antioxidative capability these components with effects improving glucose lipid metabolism in insulin‐resistant HepG2 cells. DPPH free radical scavenging reducing power assays were used to evaluate antioxidant activity extracts. An cell model induced by glucose, fructose, oleic acid, palmitic acid was adopted investigate extracts regulating this study. LC‐MS/MS then for...

10.1002/fsn3.2246 article EN Food Science & Nutrition 2021-03-29

In this study, the influences of mulberry leaf extract (MLE) addition on physicochemical properties including specific volume, texture and sensory features white bread (WB) were evaluated by analysis technology. A double-blind, randomised, repeat-measure design was used to study impact MLE postprandial blood glucose response as well satiety index WB. Results showed that no significant effects WB except for slight changes color bitterness. The significantly reduced total rise after ingestion...

10.1371/journal.pone.0288911 article EN cc-by PLoS ONE 2023-08-10

Our results suggest that, in quiescent cells, nutrient signals do not merely provoke a positive regulatory process to commence mitotic growth. Exit from the state yeast cells is regulated by balancing between and negative signaling pathways.

10.1128/spectrum.00897-22 article EN cc-by Microbiology Spectrum 2022-08-04

Abstract Mulberry ( Morus alba L.) leaf can effectively inhibit the digestion of starchy foods, and α‐glucosidase (AG) is its main target. This study employed an untargeted metabolomics approach combined with molecular docking to identify AG inhibitors. Subsequently, inhibition kinetics, fluorescence spectroscopy, interaction force analysis were utilized investigate inhibitory mechanism. Results indicated that vitexin exhibited significant reversible through competitive inhibition, IC 50...

10.1002/efd2.144 article EN cc-by eFood 2024-04-11

Abstract Intermittent fasting is a promising paradigm for weight loss which has been shown to modulate the gut microbiota in couple of populations, yet limited information at species level available. Here, 72 Chinese volunteers with wide range BMIs participated three-week IF program during an average 3.67 kg body accompanied improved clinical parameters was observed irrespective initial anthropometric and status. Fecal samples were collected before after intervention subjected shotgun...

10.21203/rs.3.rs-2274473/v1 preprint EN cc-by Research Square (Research Square) 2023-01-05

This article describes the optimization and fuzzy logic sensory evaluation of reconstituted rice manufacturing by a twin-screw extruder. An improved system was established, including an index set its weight set, transform rule, observation value. The result used to investigate dependent variables in process. three factors affecting product quality, together with optimal level each brackets were extruder screw speed (190 rpm), barrel temperature (76 °C), material moisture (26%). glycemic (GI)...

10.3136/fstr.fstr-d-21-00307 article EN Food Science and Technology Research 2022-01-01

Abstract Background: Glucagon like peptide 1 (GLP-1) has previously been found to regulate glycolipid metabolism in the liver by promoting insulin secretion. However, direct regulation of GLP-1 on was still controversial, due presence receptors (GLP-1R) human not determined. In this research, and effect hepatic GLP-1R were investigated L02 cells (normal hepatocytes). Methods: The resistance cell model with metabolic disorder constructed using oleic acid fructose simulate syndrome caused...

10.21203/rs.3.rs-29811/v2 preprint EN cc-by Research Square (Research Square) 2020-09-11

Abstract Background Glucagon like peptide 1 (GLP-1) has been shown to regulate glucose and lipid metabolism in the liver by promoting insulin secretion. However, direct regulation of GLP-1 on was still controversial, due presence receptors (GLP-1R) human not determined. The aim this study investigate GLP-1R L02 cells (normal hepatocytes), explore effect GLP-1, hepatic metabolism. Methods resistance (IR) cell model with metabolic disorder constructed using FFAs (including oleic acid fructose)...

10.21203/rs.3.rs-29811/v1 preprint EN cc-by Research Square (Research Square) 2020-06-04
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