A5100616442- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Airway Management and Intubation Techniques
- Cardiovascular Disease and Adiposity
- Non-Invasive Vital Sign Monitoring
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Health and Disease Prevention
- Menstrual Health and Disorders
- Spine and Intervertebral Disc Pathology
- Thermal Regulation in Medicine
- Pregnancy-related medical research
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Maternal and Perinatal Health Interventions
Women's Hospital, School of Medicine, Zhejiang University
2016-2025
Creative Commons
2024
Union Hospital
2005-2024
Huazhong University of Science and Technology
2006-2024
Zhejiang University
2006-2024
Wuhan Union Hospital
2019
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
Tongji University
2019
China-Japan Friendship Hospital
2019
Importance Epidural anesthesia is a primary choice for cesarean delivery, but supplemental analgesics are often required to relieve pain during uterine traction. Objective To investigate the sedative and analgesic effects of intravenous esketamine administered before childbirth via delivery with patient under epidural anesthesia. Design, Setting, Participants This multicenter, double-blind randomized clinical trial assessed 903 women 18 years or older who had full-term single pregnancy were...
Abstract Objective To determine whether a single low dose of esketamine administered after childbirth reduces postpartum depression in mothers with prenatal depression. Design Randomised, double blind, placebo controlled trial two parallel arms. Setting Five tertiary care hospitals China, 19 June 2020 to 3 August 2022. Participants 364 aged ≥18 years who had at least mild as indicated by Edinburgh postnatal scale scores ≥10 (range 0-30, higher indicating worse depression) and were admitted...
Surgical stress index (SSI), a novel multivariate index, has recently been proven to react well surgical nociceptive stimuli and analgesic drug concentration changes during general anesthesia. We investigated the feasibility of application SSI for guidance remifentanil administration propofol-remifentanil anesthesia.Eighty patients scheduled elective ear-nose-throat surgery were randomized into two groups, SSI-guided analgesia group (SSI group) standard practice (control group). In both...
Acute lung injury (ALI) is a fatal disease in the absence of pharmacological treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells main source reactive oxygen species (ROS). Macrophages play an extremely important role ALI through activation oxidative stress. Itaconate, metabolite tricarboxylic acid, has been reported have strong antioxidant anti-inflammatory effects. However, itaconate unclear. Herein, we use 4-octyl (OI), cellular permeable derivate...
Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely elucidated, effective treatments lacking. A-fiber sensory neurons have been shown to mediate the development of mechanical allodynia pain, yet molecular basis underlying contribution still unclear. Here, we report that orphan G protein-coupled receptor 177 (GPR177) drives via WNT5a-mediated activation transient potential vanilloid receptor-1...
Postpartum depression (PPD) is a severe mental disorder that affects approximately 10–––20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development therapeutics. Gut microbiota dysbiosis considered to contribute major depressive disorder. However, associations between gut and remain unanswered. Here, we established mouse model by sudden ovarian steroid withdrawal hormone-simulated pseudopregnancy-human (HSP-H) in ovariectomy...
Abstract Background Disorders of endocrine substances in epicardial adipose tissue are known causes coronary artery disease (CAD). Adiponectin is associated with cardiovascular disease. However, expression adiponectin and its function CAD pathogenesis unclear. This study investigates patients. Methods Vessels or samples collected from patients non-CAD controls were examined after immunochemical staining. Adiponectin, cytokines interleukin-6 (IL-6) necrosis factor-α (TNF-α) toll-like receptor...
Abstract The ventrolateral periaqueductal gray (vlPAG) collaborates with the dorsal raphe (DR) in pain regulation and emotional response. However, roles of vlPAG DR γ-aminobutyric acid (GABA)-ergic neurons regulating nociception anxiety are contradictory poorly understood. Here, we observed that pharmacogenetic co-activation GABAergic (vlPAG-DR GABA+ ) enhanced sensitivity to mechanical stimulation promoted anxiety-like behavior naïve mice. Simultaneous inhibition vlPAG-DR showed adaptive...
BACKGROUND: Propofol is commonly used for procedural sedation but may increase side effects in a dose-dependent manner. Remimazolam, an ultrashort-acting benzodiazepine, has been approved delay awakening. This study tested the hypothesis that remimazolam as supplement reduces effect-site propofol concentration (Ce prop ) required to suppress response cervical dilation patients undergoing hysteroscopy. METHODS: One hundred and fifty who were scheduled hysteroscopy randomized receive 0, 0.05,...
Postpartum depression (PPD) is a widespread psychiatric condition affecting up to 20% of postpartum women. Although it known be associated with ovarian hormone withdrawal following delivery, current treatments remain limited due lack underlying mechanism. Here, in mice, we identified that semaphorin 3A (sema3A) exhibited notable increase expression within the hippocampus whereas no such upregulation was observed female mice experiencing induced by lipopolysaccharide or chronic restraint...
Validated monitoring methods for evaluating the balance of nociception and anti-nociception (BNAN) are needed in general anesthesia. This study assessed six photoplethysmography (PPG) parameters, computed from finger photoplethysmographic waveforms patients undergoing gynecological surgery under A total 20 participants were included, each anesthesia with propofol remifentanil. The same concentration remifentanil was maintained throughout experiment, four different intensities electrical...
This Notice of Retraction is to retract an article by Xu LL, et al.
BACKGROUND: Ondansetron has been shown to reduce the incidence of hypotension and vasopressor requirement during spinal anesthesia for obstetric nonobstetric surgery. However, magnitude this effect not fully quantified. In parallel-group, randomized, double-blinded study, we determined effective dose in 50% subjects (ED 50 ) a prophylactic phenylephrine infusion preventing patients who received single intravenous ondansetron 4 mg or saline control before combined spinal–epidural elective...
Abstract Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack consensus to regard estrogen as variable when working with animal models; thus, the influence hormones’ fluctuations on has continually been neglected. In present study, we designed novel hormone substitution model aid us evaluate effects estrogen’s long-term alterations ovariectomy (OVX)-induced...
Prophylactic IV infusion of phenylephrine has been recommended to prevent hypotension during spinal anesthesia for cesarean delivery. However, the optimal dose is unknown. This study aimed determine that would be effective in preventing 50% (ED50) and 90% (ED90) patients when administered as a prophylactic at fixed rate based on individual body weight.Eighty parturients scheduled elective delivery were randomly allocated receive 0.25, 0.375, 0.5, or 0.625 µg/kg/min (n = 20 per group) started...
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation. However, there were some shortcomings higher doses of remimazolam during hysteroscopy in spite less frequent adverse events. The aim this study was to find 50% and 95% effective dose (ED50 ED95) when combined with propofol intravenous sedation day-surgery hysteroscopy.Patients randomly assigned evenly (20 per group) one five different dosage remimazolam: group A (0.05mg/kg), B (0.075mg/kg), C...
Catheter-based techniques such as combined spinal-epidural (CSE) anesthesia which are sometimes indicated for obstetric have a complex mechanism of action. The application the dural puncture epidural (DPE) cesarean section (CS) has not been well investigated. present study compared relatively novel DPE technique with (EA) and CSE anesthesia.We randomly assigned 150 parturients who underwent elective CS to receive DPE, EA or anesthesia. primary outcome was onset sensory T5 dermatome assessed...
Addition of intrathecal magnesium sulfate to local anesthetics has been reported potentiate spinal anesthesia and prolong analgesia in parturients. The current study was determine whether would reduce the dose hyperbaric bupivacaine with sufentanil for cesarean delivery. Sixty healthy parturients undergoing scheduled delivery were randomly assigned receive 0.5% 5 μg either 0.9% sodium chloride (Control group) or 50% (50 mg) (Magnesium group). Effective defined as a bilateral T5 sensory block...