We examine whether the occurrence of jumps in return major cryptocurrencies increases likelihood stock returns blockchain and crypto-exposed US companies. use two criteria to identify stocks with cryptocurrency exposure; i) text search ii) membership indices. first detect that both asset classes are subject jump behaviour. Then, we employ logistic regressions show some probability several The co-jumping behaviour is not affected by COVID-19 outbreak.

This study compared the diagnostic performance of Ovarian-Adnexal Reporting and Data System (O-RADS), Risk Malignancy Index 4 (RMI4), International Ovarian Tumor Analysis Logistic Regression Model 2 (IOTA LR2), IOTA Simple Rules SR) in predicting malignancy adnexal masses (AMs).This retrospective included 575 women with AMs between 2017 2020. All clinical messages, ultrasound images, pathological findings were collected. Two senior doctors (group I) two junior II) used four systems to...

Drainage pattern recognition is crucial for geospatial understanding and hydrologic modelling. Currently, drainage methods employ geometric measures of overall local features river networks but lack basin unit shape features, so that potential correlations between segments are usually ignored, resulting in poor results. In order to overcome this problem, paper proposes a supervised graph neural network method considers the networks. First, based on hierarchy networks, confluence angle units,...

Postpartum depression (PPD) is a widespread psychiatric condition affecting up to 20% of postpartum women. Although it known be associated with ovarian hormone withdrawal following delivery, current treatments remain limited due lack underlying mechanism. Here, in mice, we identified that semaphorin 3A (sema3A) exhibited notable increase expression within the hippocampus whereas no such upregulation was observed female mice experiencing induced by lipopolysaccharide or chronic restraint...

Arteriovenous fistula stenosis is a common complication in hemodialysis patients, yet effective predictive tools are lacking. This study aims to develop an interpretable machine learning model for risk prediction. Clinical data from 974 patients (55 features) undergoing arteriovenous dialysis at The Central Hospital of Wuhan (2017-2024) were analyzed retrospectively. dataset was split into training (70%) and test (30%) sets. Seven models-Random Forest, XGBoost, Support Vector Machine,...

Background Owing to the coronavirus disease 2019 (COVID-19) pandemic and emergency use of different types COVID-19 vaccines, there is an urgent need consider effectiveness persistence vaccines. Methods We investigated immunogenicity CoronaVac Covilo, two inactivated vaccines against that each contain severe acute respiratory syndrome 2 (SARS-CoV-2). The levels neutralizing antibodies live SARS-CoV-2 inhibition rates pseudovirus, as well immunoglobulin (Ig)G IgM responses towards spike (S)...

Objective Varicella, a highly contagious viral disease caused by the varicella-zoster virus (VZV), affects millions globally, with higher prevalence among children. After initial infection, VZV lies dormant in sensory ganglia and has potential to reactivate much later, causing herpes zoster (HZ). Vaccination is one of most effective methods prevent varicella, two-dose varicella vaccine (VarV) regimen widely used around world. In China, VarV been included national immunization programme...

Postpartum depression (PPD) is a common neuropsychiatric disorder characterized by and comorbid anxiety during the postpartum period. PPD difficult to treat because of its elusive mechanisms. Epigallocatechin-3-gallate (EGCG), component tea polyphenols, reported exert neuroprotective effects in emotional disorders reducing inflammation apoptosis. However, effect EGCG on underlying mechanism are unknown.We used mouse model established exposing pregnant mice gestational stress. Open field,...

Background Fungal infections are associated with high morbidity and mortality in the intensive care unit (ICU), but their diagnosis is difficult. In this study, machine learning was applied to design define predictive model of ICU-acquired fungi (ICU-AF) early stage fungal using Random Forest. Objectives This study aimed provide evidence for warning management infections. Methods We analyzed data patients culture-positive during admission seven ICUs First Affiliated Hospital Chongqing...

The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune cells in TME. Here, we report inorganic nanozymes (i.e., SnSe NSs) that mimic catalytic lactate dehydrogenase degrade pyruvate, contributing metabolic treatment tumors. As found this study, NSs successfully decreased levels tumors, as well reduced acidity. This associated with activation response T cells, thus alleviating immunosuppressive environment More importantly, nanozyme inhibited growth...

Abstract Bufalin, a major cardiotonic compound of the traditional Chinese medicine Chanshu has been used for cancer treatment several years. However, molecular mechanisms Bufalin‐induced autophagy in osteosarcoma (OS) is not fully understood. In present study, it was shown that Bufalin induced crosstalk between apoptosis and autophagy, which resulted OS cell death. Mechanistically, by increased ratio microtubule‐associated protein 1A/1B‐light chain 3 (LC3)‐II/LC3‐I, inducing via...

Abstract Background This study aimed to compare the diagnostic efficiency of Ovarian-Adnexal Reporting and Data System (O-RADS) doctors’ subjective judgment in diagnosing malignancy risk adnexal masses. Methods was an analysis 616 masses between 2017 2020. The clinical findings, preoperative ultrasound images, pathological diagnosis were recorded. Each mass evaluated by O-RADS two senior doctors junior doctors. A with grade 1 3 a benign tumor, 4–5 malignant tumor. All outcomes compared...

BACKGROUND:Intrauterine adhesion (IUA) is a common reproductive system disease in women, characterized by endometrial stromal cell proliferation, increasing fibroblasts and extracellular matrix secretion. The purpose of this study was to investigate the effect mitomycin C on reducing fibrosis for IUA. MATERIAL AND METHODS:Firstly, rat IUA model constructed intrauterine mechanical injury. cells were isolated treated with C. After that, Cell Counting Kit-8 (CCK-8) assay used viability....

Background: We aimed to explore the risk factors of lung nodules and cancer in physical ex-amination population with low-dose multi-slice spiral CT (LDCT) screening, provide basis for screening follow-up management after examination. Methods: The general data, serum tumor markers images 2,274 patients underwent LDCT Physical Examination Center Fourth Hospital Hebei Medical University, China 2019 were retrospectively analyzed followed up three years. Results: detection rate was 48.42%. higher...

Background: Thyroid cancer is the most common endocrine today.Differentiated thyroid (DTC) comprises more than 95% of all cancers.With increasing incidence tumors and development screening, patients suffer from multiple cancers.The purpose this study was to explore prognostic value a history prior malignancy for stage I DTC.Methods: Stage DTC were identified Surveillance, Epidemiology, End Results (SEER) database.The Kaplan-Meier method Cox proportional hazards regression used determine risk...

Aiming at the problem that traditional path planning algorithm does not have real-time performance in dynamic and complex power equipment maintenance environment, or it is challenging to avoid obstacle obstacles due poor version, this paper proposes an artificial potential field method for planning. The characteristics of a are simplified as moving particles, repulsion function added collision. Within influence range busy robot avoids through local under repulsive force reach target point....

Hepatitis E virus (HEV) infection is relatively high in the southern regions of China. Yunnan, located southwestern China, has highest number ethnic groups. However, HEV population largely unknown. Therefore, we aimed to investigate seropositive rate, risk factor, and clinical impact groups Yunnan. We recruited 1912 individuals from four minority three prefectures Yunnan province. Epidemiological records on potential factors for exposure blood biochemical index were analyzed. All serum...

Safe medication management and use of high-alert narcotics should arouse concern. Risk experiences in this respect a large-scale Joint Commission International (JCI)-accredited academic medical center hospital the People's Republic China during 2011-2015, focusing on organizational, educational, motivational, information technological measures storage, prescribing, preparing, dispensing, administration, monitoring are summarized. The intensity meperidine hospitalized patients 2015 was...

Improving osmotic stress tolerance is critical to help crops thrive and maintain high yields in adverse environments. Here, we characterized a core subunit of the transport protein particle (TRAPP) complex, ZmBET5L1, maize using knowledge-driven data mining genome editing. We found that ZmBET5L1 can interact with TRAPP I complex subunits act as tethering factor mediate vesicle aggregation targeting from endoplasmic reticulum Golgi apparatus. knock-out increased primary root elongation rate...