A5100669027- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Hernia repair and management
- Eosinophilic Disorders and Syndromes
- Liver Disease Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Plant responses to water stress
- Virology and Viral Diseases
- Synthesis of Indole Derivatives
- Dermatology and Skin Diseases
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Congenital Diaphragmatic Hernia Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Ningxia Medical University
2017-2025
Jilin University
2018-2025
Union Hospital
2018-2025
Beijing Sport University
2025
First Affiliated Hospital of Xiamen University
2024
Tianjin Medical University
2021-2024
Ningxia Medical University General Hospital
2020-2024
First Affiliated Hospital of Zhengzhou University
2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that has been associated with several types of cancer. However, its biological significance, as well related mechanism in endometrial cancer (EC) still remains elusive. In this study, we examined the function calcium EC, specific focus on TRPV4 and downstream pathway. We reported here findings high level serum ionized was significantly correlated advanced EC progression, among all channels, played an...
Background: Ultraviolet (UV) is a common stressor of skin and repeated UVA radiation contributes to photoaging. (–)-Epigallocatechin-3-Gallate (EGCG), as the major polyphenol that found in green tea, catechins have shown considerable antioxidant capacity. Purpose: Our study aims explore effects EGCG on UVA-induced photoaging process associated mechanisms. Methods: In this study, human fibroblasts (HSFs) were treated with EGCG, subsequent changes cell morphology, telomeres, capacity, cycle,...
Alveolar epithelia play an essential role in maintaining the integrity and homeostasis of lungs, which alveolar epithelial type II cells (AECII) are a cell with stem potential for injury repair regeneration. However, mechanisms behind physiological pathological roles human lungs remain largely unknown, partially owing to difficulty isolation culture primary AECII cells. In present study, we aimed characterize generated from A549 lung adenocarcinoma that were cultured air-liquid interface...
The oxidative stresses are a major insult in pulmonary injury such as acute lung (ALI) and respiratory distress syndrome (ARDS), two clinical manifestations of failure with substantially high morbidity mortality. Mesenchymal stem cells (MSCs) hold promise treatments many human diseases, mainly owing to their capacities immunoregulation antioxidative activity. strong immunoregulatory role placental MSCs fetal origin (hfPMSCs) has been previously demonstrated; antioxidant activity, however,...
Abstract Background Neutrophil extracellular trap (NET) formation has been implicated as a pathogenic mechanism in both rheumatoid arthritis (RA) and interstitial lung disease (ILD). However, the role of NETs RA-associated ILD (RA-ILD) mechanisms driving NET remain unclear. This study aimed to assess involvement RA-ILD elucidate underlying mechanisms. Methods Single-cell sequencing was used identify changes quantity function neutrophils tissue zymosan A (ZYM)-induced pneumonia model....
As the global population ages, obesity among older adults has become an increasing public health concern. Lifestyle factors, including physical activity (PA) and sleep, play a critical role in prevention. These behaviors occur within 24-hour cycle, yet research on impact of different PA patterns, trouble sleeping, their combination remains limited. This study aimed to explore: (1) relationship between Americans; (2) combined effect patterns sleeping this population. A total 10,891...
Fibroblasts were the main seed cells in studies of tissue engineering pelvic floor ligament. Basic fibroblast growth factor (bFGF) and epidermal (EGF) widely studied but at various concentrations. This study aimed to optimize concentrations combined bFGF EGF by evaluating their effects on proliferation collagen secretion fibroblasts.Fibroblasts differentiated from rat adipose mesenchymal stem (ADSCs). Flow cytometry immunohistochemistry used for cell identification. The factors applied 0, 1,...
Pelvic organ prolapse (POP) harms the quality of life elderly patients. Transvaginal polypropylene mesh repair for POP was a frequently reported complication and banned by FDA in 2019. New therapeutic strategies are urgently required, tissue engineering technology could be novel therapy. Here, we developed out three components: silk fibroin (SF) knitted loaded with basic fibroblast growth factor (bFGF) adipose-derived stem cells (ADSCs). We used coaxial electrospinning to achieve local bFGF...
Abstract Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive cancer with poor prognosis. Killing cells by inducing DNA damage or blockage of repair promising strategy for chemotherapy. It reported that aldehyde-reactive alkoxyamines can capture the AP sites, one most common lesions, and inhibit apurinic/apyrimidinic endonuclease 1(APE1)-mediated base excision (BER), leading to cell death. Whether this be employed ATC treatment rarely investigated. The aim study exploit...
In order to validate the antiviral effect against hepatitis B virus (HBV) of Taraxacum mongolicum (T. mongolicum), protective on hepatocytes, and properties duck (DHBV) HBV T. extract (TME) were evaluated in chemically‑injured neonatal rat DHBV-infected fetal hepatocytes HBV-transfected HepG2.2.15 cells, respectively. The results demonstrated that TME at 50-100 µg/ml improved D-galactosamine (D-GalN), thioacetamide (TAA) tert-butyl hydroperoxide (t-BHP)-injured produced protection rates...