A5101567730- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Prenatal Screening and Diagnostics
- Exercise and Physiological Responses
- Microfinance and Financial Inclusion
- Chemokine receptors and signaling
- Housing Market and Economics
- Economic Growth and Development
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Nanoparticle-Based Drug Delivery
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Gynecological conditions and treatments
- Urological Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- FinTech, Crowdfunding, Digital Finance
- 3D Printing in Biomedical Research
- Lipid metabolism and disorders
First Affiliated Hospital of Xiamen University
2019-2024
Nanjing Audit University
2022-2023
Institute of Economics
2022-2023
Xiamen University
2019-2021
Second Military Medical University
2017-2021
KTH Royal Institute of Technology
2016-2020
State Council of the People's Republic of China
2019
Harbin Medical University
2017
First Affiliated Hospital of Harbin Medical University
2017
University of Bergen
2016
Implantation of the blastocyst into uterus is gateway for further embryonic development in mammals. Programming to an implantation-competent state known as activation determining factor implantation receptive uterus. However, it remains largely unclear how globally programmed implantation. Employing a delayed mouse model, we show here that undergoes extensive programming essential By analyzing transcriptional profile blastocysts with different competency, reveal dynamic change biosynthesis,...
Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of RM remains unclear, growing evidence has indicated relevance trophoblast impairment to pathogenesis RM. PR-SET7 sole enzyme catalyzing monomethylation H4K20 (H4K20me1) and been implicated in many pathophysiological processes. However, how functions trophoblasts its remain unknown. Here, we found that trophoblast-specific loss Pr-set7 mice led defective trophoblasts, resulting early embryonic loss....
The aim is to evaluate the effect of modifying poly[( l ‐lactide)‐co‐(ε‐caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or nDP+physisorbed BMP‐2 (nDP+BMP‐2) on in vivo host tissue response and degradation. are implanted subcutaneously Balb/c mice retrieved after 1, 8, 27 weeks. Molecular weight analysis shows that modified degrade faster than unmodified. Gene at week 1 highest expression proinflammatory markers around nDP scaffolds; although presence inflammatory cells foreign body...
The decidua plays a crucial role in providing structural and trophic support to the developing conceptus before placentation. Following embryo attachment, embryonic components intimately interact with decidual tissue. While evidence indicates participation of embryo-derived factors crosstalk uterus, extent their impact on post-implantation development requires further investigation. Here, we utilize transgenic mouse models selectively eliminate primary trophoblast giant cells (pTGCs), that...
Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) poly(LLA-co-CL)) porous scaffolds are good candidates for use as biodegradable scaffold materials in the field of tissue engineering; meanwhile, their surface properties, such hydrophilicity, need to be further improved. Methods: We applied several different concentrations surfactant Tween 80 tune hydrophilicity materials. Moreover,...
Selection of appropriate osteoinductive growth factors, suitable delivery method and proper supportive scaffold are critical for a successful outcome in bone tissue engineering using marrow stromal cells (BMSC). This study examined the molecular functional effect combination adenoviral mediated expression morphogenetic protein-2 (BMP2) BMSC recently developed characterized, biodegradable Poly(L-lactide-co-є-caprolactone){poly(LLA-co-CL)}scaffolds osteogenic changes ectopic formation by vitro...
Abstract The placenta, responsible for the nutrient and gas exchange between mother fetus, is pivotal successful pregnancy. It has been shown that Rbpj, core transcriptional mediator of Notch signaling pathway, required normal placentation in mice. However, it remains largely unclear how Rbpj different placental compartments coordinates with other important regulators to ensure morphogenesis. In this study, we found systemic deletion led abnormal chorioallantoic morphogenesis defective...
Primary malignant mixed Müllerian tumors (MMMT) of the fallopian tube are extremely rare with a high potential and poor prognosis. We report case primary MMMT right in 46-year-old woman presenting irregular vaginal bleeding. Microscopically, tumor was composed poorly differentiated adenocarcinoma leiomyosacrcoma. also discuss clinical course pathologic findings along other cases reported previously literature.
The maternal recognition of pregnancy is a necessary prerequisite for gestation maintenance through prolonging the corpus luteum lifespan and ensuring progesterone production. In addition to pituitary prolactin placental lactogens, decidual derived family members have been presumed possess luteotropic effect. However, there was lack convincing evidence support this hypothesis. Here, we unveiled an essential role uterine Notch2 in maintenance. Uterine-specific deletion did not affect female...
Abstract Proper development of the human placenta is vital importance for a successful pregnancy, and series pregnancy complications are considered originating from dysfunctional placentas. Like other organ system development, placentation requires large numbers co-regulators, while underlying molecular mechanisms orchestrating placental formation function poorly understood. Although we have made many signs progress in understanding architectures developments using mouse models,...
Objective Ureteropelvic junction obstruction (UPJO) is a common cause of hydronephrosis in children. A reduction renal function an important feature kidney. Occasionally hydronephrotic kidney has higher than normal differential (DRF). Whenever DRF exceeds 55%, it regarded as supra-normal phenomenon. The clinical, imaging and prognostic characteristics children (received pyeloplasty) with (SNDRF) were analyzed. Methods We searched for 13 SNDRF (unilateral UPJO) undergoing pyeloplasty...
Background: At present, there are still no official or semi-official recommendations for the treatment of muscle fatigue. We previously reported that acute phase protein orosomucoid (ORM) can enhance endurance and exert anti-fatigue effect, but with limited clinical application. Here, we try to seek drugs target ORM, further clarify its potential mechanism.Methods: Weight-loaded forced swimming electrically evoking isolated soleus contractions were applied measure fatigue levels. Electron...