Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells (BMSC-EVs) can play important roles in the repair of injured tissues. However, no reports have investigated role and underlying mechanisms BMSCs-EVs tendon process. We hypothesized that BMSC-EVs may a modulating inflammation during healing improving rat model patellar injury. First, we created window defects tendons Sprague–Dawley rats. Rats (n = 16) were then randomly assigned to three groups: group,...

Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair of injured tissues. Though numerous studies have reported effect EVs on renal fibrosis, underlying mechanisms remain unclear. We hypothesized that BMSC-EVs containing milk fat globule-epidermal growth factor-factor 8 (MFG-E8) could attenuate fibrosis inhibiting RhoA/ROCK pathway.We investigated whether anti-fibrotic effects a rat model which rats were subjected to...

ABSTRACT Childhood vitiligo, distinct from its adult counterpart, presents unique treatment challenges. Glycyrrhizin inhibits the release of high‐mobility group box 1 (HMGB1) protein keratinocytes, preventing melanocyte apoptosis and autophagy. Furthermore, orally administered compound glycyrrhizin (OCG) effectively treats various autoimmune disorders, demonstrating long‐term efficacy, safety, tolerability. This study compared efficacy OCG oral prednisone (OP), followed by phototherapy, in...

To investigate the incidence and clinical characteristics of congenital anomalies kidney urinary tract (CAKUT) in children with heart defects (CHD).We retrospectively analyzed data CHD CAKUT admitted to Shanghai Children's Medical Center affiliated Jiao Tong University School Medicine between September 2018 March 2019. Patients underwent routine examinations for liver, kidney, coagulation function, ultrasonography, we summarized patients' manifestations imaging abnormalities.A total 1,410...

5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for pilosebaceous inflammatory diseases, such as acne vulgaris. In this study, we explored ALA-PDT's mechanisms against in vitro.

Abstract Several studies have identified potential roles for MFG‐E8 in promoting tissue repair. However, the effects of on tendon repair not yet been investigated. Therefore, we explored role using a rat model patellar injury. The tendons Sprague Dawley rats ( n = 24/group) received window defects and, after modeling, three groups were randomly assigned: (a) recombinant (rMFG‐E8) group, implantation with and fibrin glue (400 ng 10 μl); (b) only; (c) control without any treatment....

Recent investigations described the use of urinary matrix remodeling-associated protein 5 (MXRA5) as a novel biomarker for kidney impairment in setting chronic disease. In this study, we aimed to evaluate possible clinical application MXRA5 useful noninvasive marker urine from affected renal pelvis and bladder children with ureteropelvic junction obstruction (UPJO). This prospective cohort study enrolled patients aged <12 months prenatally diagnosed unilateral UPJO who received dismembered...

Background: Urethral stricture (US) is a major challenge in urology and there an urgent need for effective therapies its treatment. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs-Exos) have been shown to be preventing scar fibrosis formation after tissue injury. However, the potential utility of BMSCs-Exos prevention US remains unknown. We hypothesized that local administration may influence urethral healing rat model US.

Laser is being widely used in treating pigmented lesions nowadays. Linear and whorled nevoid hypermelanosis (LWNH) a rare pigmentary anomaly, there are only handful of cases successful treatment, all with QS 532- 755-nm laser. The objective this study was to examine the clinical outcome 694-nm ruby laser treatment LWNH. We report on 4-year-old boy presented asymptomatic macular hyperpigmentation over entire cheek who underwent 3 sessions One month after last patient demonstrated significant...

Purpose: Nicotine causes tendon degeneration, whereas ascorbic acid imparts beneficial effects on cells. Tendon stem cells (TSCs) play a vital role in maintaining tissue integrity and promoting restoration of structure function after injury. In the present study, cell culture experiments were performed to determine nicotine TSCs whether supplementation could antagonize action high concentration nicotine.Methods: After treatment with acid, TSC proliferation, migration, stemness, apoptosis,...

To investigate the perceptions, attitudes, and treatment selection of Chinese pediatric urologists surgeons regarding a "watch wait" strategy for multicystic dysplastic kidney (MCDK). We used cross-sectional survey in this study. sent questionnaire to capture their views via "Questionnaire Star" online platform between November December 2019. The contained basic information surgical experiences respondent, respondents' awareness counseling prenatally-diagnosed MCDK MCDK, knowledge imaging...

Abstract Background: Renal interstitial fibrosis is a critical symptom of chronic kidney disease that associated with high incidence. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair injured tissues. Though numerous studies have reported effect EVs on renal fibrosis, underlying mechanisms remain unclear. We hypothesized BMSC-EVs containing milk fat globule–epidermal growth factor–factor 8 (MFG-E8) could attenuate...

Objective Ureteropelvic junction obstruction (UPJO) is a common cause of hydronephrosis in children. A reduction renal function an important feature kidney. Occasionally hydronephrotic kidney has higher than normal differential (DRF). Whenever DRF exceeds 55%, it regarded as supra-normal phenomenon. The clinical, imaging and prognostic characteristics children (received pyeloplasty) with (SNDRF) were analyzed. Methods We searched for 13 SNDRF (unilateral UPJO) undergoing pyeloplasty...

Objective Hydronephrosis due to ureteropelvic junction obstruction (UPJO) is characterized by long-term stability or progressive exacerbation in children. However, a few of them have intermittent hydronephrosis. The clinical and imaging characteristics hydronephrosis were analyzed for 37 UPJO children. Methods Retrospective analysis was performed hospitalized children aged 3-14 years with from July 2013 December 2017. Routine liver & renal function tests, urinary tract ultrasound...

Objective To explore the prevalence and clinical characteristics of congenital anomalies kidney urinary tract (CAKUT) with cryptorchidism in children. Methods A total 21 children CAKUT were recruited from January 2017 to August 2018.Their complete imaging data collected symptoms abnormalities summarized. Results The number genitourinary was 26.The major diseases included hydronephrosis, renal hypoplasia duplex collecting system.No association existed between parity or paternal...

Abstract Background Renal interstitial fibrosis is a critical symptom of chronic kidney disease (CKD) that associated with high incidence. Extracellular vesicles produced by bone marrow mesenchymal stem cells (BMSC-EVs) can play important roles in the repair injured tissues. However, no reports have investigated role and mechanism BMSC-EVs renal fibrosis. Thus, we hypothesized containing milk fat globule-EGF factor-8 (MFG-E8) could attenuate inhibiting RhoA/ROCK pathway.Methods We whether...