A5078570109- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Pregnancy and preeclampsia studies
Xiamen University
2024
First Affiliated Hospital of Xiamen University
2023
Recurrent miscarriage (RM) is a distressing pregnancy complication. While the etiology of RM remains unclear, growing evidence has indicated relevance trophoblast impairment to pathogenesis RM. PR-SET7 sole enzyme catalyzing monomethylation H4K20 (H4K20me1) and been implicated in many pathophysiological processes. However, how functions trophoblasts its remain unknown. Here, we found that trophoblast-specific loss Pr-set7 mice led defective trophoblasts, resulting early embryonic loss....
Nutrient sensing and adaptation in the placenta are essential for pregnancy viability proper fetal growth. Our recent study demonstrated that adapts to nutrient insufficiency through mechanistic target of rapamycin (mTOR) inhibition–mediated trophoblast differentiation toward syncytiotrophoblasts (STBs), a highly specialized multinucleated subtype mediating extensive maternal–fetal interactions. However, underlying mechanism remains elusive. Here, we unravel indispensable role mTORC1...