A5088096919- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Oral and Maxillofacial Pathology
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Bone Tumor Diagnosis and Treatments
- Temporomandibular Joint Disorders
- Angiogenesis and VEGF in Cancer
- Surgical Simulation and Training
- Sinusitis and nasal conditions
- Tissue Engineering and Regenerative Medicine
- Cancer Diagnosis and Treatment
- Tattoo and Body Piercing Complications
- Facial Trauma and Fracture Management
- Orthodontics and Dentofacial Orthopedics
- Oropharyngeal Anatomy and Pathologies
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Dental Radiography and Imaging
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- Genetic Syndromes and Imprinting
- Heterotopic Ossification and Related Conditions
University of Bergen
2013-2025
Haukeland University Hospital
2018-2025
Bergen Kommune
2023
A low dose of 1μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone) [(poly(LLA-co-CL)] scaffolds. It either (i) physisorbed unmodified scaffolds [PHY], (ii) onto modified with nanodiamond particles [nDP-PHY], (iii) covalently linked nDPs that were used to modify the [nDP-COV] or (iv) encapsulated in microspheres distributed [MICS]. Release kinetics BMP-2 from quantified using targeted mass spectrometry for up...
Abstract Introduction Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular assemble into complex regulating proliferation ECs, vessel diameter production extracellular matrix proteins. The aim this study was to evaluate the ability mesenchymal stem (MSCs) establish an endothelial-perivascular in tissue-engineered constructs comprising ECs MSCs. Methods Primary human MSCs were...
Significant evidence has indicated that poly(L-lactide)-co-(ɛ-caprolactone) [(poly(LLA-co-CL)] scaffolds could be one of the suitable candidates for bone tissue engineering. Oxygen-terminated nanodiamond particles (n-DP) were combined with poly(LLA-co-CL) and revealed to positive cell growth. In this study, we evaluated influence modified by n-DP on attachment, proliferation, differentiation marrow stromal cells (BMSCs) in vitro, formation using a sheep calvarial defect model. BMSCs seeded...
Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. Therefore, objective of this study was to determine effect marrow stromal stem cells (BMSCs) density loaded onto copolymer scaffolds on regeneration. BMSCs were harvested from rat's and cultured in media with or without osteogenic supplements. Cells seeded poly(l-lactide-co-ε-caprolactone) [poly(LLA-co-CL)] at two different densities: low (1 × 10(6) cells/scaffold) high (2 using spinner...
Abstract Introduction A major determinant of the potential size cell/scaffold constructs in tissue engineering is vascularization. The aims this study were twofold: first to determine vitro angiogenic and osteogenic gene-expression profiles endothelial cells (ECs) mesenchymal stem (MSCs) cocultured a dynamic 3D environment; second, assess differentiation for osteogenesis after vivo implantation. Methods MSCs ECs grown culture poly(L-lactide-co-1,5-dioxepan-2-one) (poly(LLA-co-DXO)) copolymer...
The aim is to evaluate the effect of modifying poly[( l ‐lactide)‐co‐(ε‐caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or nDP+physisorbed BMP‐2 (nDP+BMP‐2) on in vivo host tissue response and degradation. are implanted subcutaneously Balb/c mice retrieved after 1, 8, 27 weeks. Molecular weight analysis shows that modified degrade faster than unmodified. Gene at week 1 highest expression proinflammatory markers around nDP scaffolds; although presence inflammatory cells foreign body...
It has been suggested that the effect of implanted cells on local environment is important when selecting appropriate cell type for tissue regeneration. Our aim was to compare response human mesenchymal stem (MSC) and umbilical vein endothelial (EC). MSC EC were cultured in poly(L-lactide-co-1,5-dioxepan-2-one) scaffolds 1 week a bioreactor system, after which they subcutaneously NOD/SCID mice. After 3 weeks, retrieved, mRNA expression selected genes involved hypoxia inflammation examined by...
Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose this study was to investigate the effect RvD1 on bone regeneration using rat calvarial defect model. Collagen 3D nanopore scaffold (COL) and Pluronic F127 hydrogel (F127) incorporated with (RvD1-COL-F127 group) or COL (COL-F127 were implanted in symmetrical defects. After implantation, administrated subcutaneously every 7 days for 4 weeks. rats...
Osteoradionecrosis of the jaw is a therapy-resistant condition that may occur after treatment for head and neck cancer. The aim this study was to investigate incidence osteoradionecrosis in patients with oropharyngeal cancer relation tooth extraction prior radiation therapy.Patients who had undergone therapy 5-10 years earlier were included evaluated development (n = 75).Among 75 patients, 62 molar teeth present >50 Gy field 36 those extracted therapy. Extraction molars before radiotherapy...
To optimize culture conditions for in vitro prevascularization of tissue-engineered bone constructs, the development organotypic blood vessels under osteogenic stimulatory (OM) was investigated. Coculture endothelial cells and mesenchymal stem used to assess proangiogenic effects on cells. Four different were evaluated their effect microvascular cell networks. Mineralization, deposition extracellular matrix, perivascular gene expression studied OM. After 3 days, established elongated...
A promising alternative to current treatment options for degenerative conditions of the temporomandibular joint (TMJ) is cartilage tissue engineering, using 3D printed scaffolds and mesenchymal stem cells. Gelatin, with its inherent biocompatibility printability has been proposed as a scaffold biomaterial, but because thermoreversible properties, rapid degradation inadequate strength it must be crosslinked stable in physiological conditions. The aim this study was identify non-toxic...
Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim this study was to investigate influence human umbilical vein endothelial cells (ECs) on leukocyte transmigration when co-cultured with primary bone marrow-derived multipotent stromal (MSCs). MSCs without ECs were cultured poly (L-lactide-co-1, 5-dioxepan-2-one) (poly (LLA-co-DXO)) scaffolds for 1 week vitro bioreactor system, after which they implanted...
Gelatin has emerged as a biocompatible polymer with high printability in scaffold-based tissue engineering. The aim of the current study was to investigate potential genipin-crosslinked 3D printed gelatin scaffolds for temporomandibular joint (TMJ) cartilage regeneration. Crosslinking genipin increased stability and mechanical properties, without any cytotoxic effects. Chondrogenic differentiation human bone marrow-derived mesenchymal stem cells (hBMSC) on were compared cell pellets spheres....
Tissue engineering for fibrocartilage regeneration using mesenchymal stromal cells (MSC) and biomaterial scaffolds is emerging as a promising strategy, but inhibiting vascularization to prevent endochondral ossification important develop stable implants. The objective of this study was investigate the effect angiostatin on inhibition angiogenesis promotion chondrogenesis by collagen with or without MSC implanted subcutaneously in rats. One scaffold from following groups each animal: Collagen...
Klinisk hovedbudskap Forbeining av tyggemuskulatur, kjent som ossifiserende myositt, kan inntreffe etter lokalt traume i munnhulen, også administrasjon lokalanestesi. Tilstanden er svært sjelden, men må vurderes en differensialdiagnose for pasienter med vedvarende gapebesvær invasiv prosedyre munnhulen.
Traumatic myositis ossificans of the temporal muscle can occur following local trauma
Abstract Total joint prostheses are a viable treatment option after removal of malignancies invading the temporomandibular joint, even when adjuvant radiation therapy is required.
Injection phobia and dental anxiety can, in severe cases, lead to avoidance of necessary treatment. The aim this pilot study was investigate self-reported injection among individuals with tattoos and/or piercings. Phobia Scale-Anxiety (IPSA) short form the Modified Dental Anxiety Scale (MDAS) questionnaires were applied. Both total IPSA MDAS scores significantly higher for comparison a control group (P < 0.001), suggesting need anxiety-reducing measures facilitated treatment patients.