A5101405327- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Paraquat toxicity studies and treatments
- Occupational and environmental lung diseases
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Parathyroid Disorders and Treatments
- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
- Molecular Communication and Nanonetworks
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Renin-Angiotensin System Studies
- Polyomavirus and related diseases
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Macrophage Migration Inhibitory Factor
- Wnt/β-catenin signaling in development and cancer
- Polysaccharides and Plant Cell Walls
Ningxia Medical University
2014-2024
Ningxia University
2017-2023
University of Iowa
2021
Kunming Medical University
2018
Beijing University of Chinese Medicine
2017
Union Hospital
2013
Huazhong University of Science and Technology
2013
Mayo Clinic in Arizona
1995
Lycium barbarum L. polysaccharide (LBP) is prepared from (L. barbarum), which a traditional Chinese medicine. LPB has been shown to have hypoglycemic effects. In order gain some mechanistic insights on the effects of LBP, we investigated uptake LBP and its effect glucose absorption in human intestinal epithelial cell line Caco2 cell. The through monolayer was time-dependent inhibited by phloridzin, competitive inhibitor SGLT-1. decreased cell, down-regulated expression These results suggest...
(1) Background: Silicosis, a chronic lung fibrosis disorder triggered by the accumulation of silica dust in deep regions, is characterized intricate molecular mechanisms. Among these, NOX2 (NADPH oxidase 2) and JNK (C-Jun N-terminal kinase) signaling pathways play pivotal roles progression pulmonary fibrosis. Despite their significance, precise mechanisms underlying crosstalk between these remain largely unexplored. (2) Methods: To unravel interactions, we examined interplay human epithelial...
ABSTRACT Epithelial‐mesenchymal transition (EMT) is believed to be involved in lung fibrosis process induced by paraquat (PQ); however, the molecular mechanism of this has not been clearly established. The present study investigated potential involvement EMT after PQ poisoning. expressions markers, such as E‐cadherin and α‐smooth muscle actin (α‐SMA), at multiple time points exposure different concentrations were evaluated western blot analysis. Following treatment, induction was observed...
Silicosis is a chronic fibrotic lung disease caused by the accumulation of silica dust in distal lung. Canonical Wnt signaling and NADPH oxidase 4 (NOX4) have been demonstrated to play crucial role pathogenesis pulmonary fibrosis including silicosis. However, underlying mechanisms crosstalk between these two signalings are not fully understood. In present study, we aimed explore interaction Wnt/β-catenin NOX4 human epithelial cells response an exposure dust. Results elevated expression key...
Abstract The objective of the present study was to explore effects environmental chemicals, such as methyl mercury, paraquat, and bisphenol A, on cell proliferation apoptosis, well expression levels neuronal differentiation‐related genes in neural stem cells (NSCs). NSCs originated from human umbilical cord blood (HUCB‐NSCs) were used models current study. CCK‐8 flow cytometry experiments performed assess A apoptosis HUCB‐NSCs at different processes, including differentiation stages....
Atrazine (ATR) is a widely applied herbicide which was named an environmental endocrine disrupting chemical (EDC). Increasing evidence indicates ATR causes neurotoxic effects resulting in central nervous system (CNS) disease. As the primary immunocytes CNS, microglia cells carry out their phagocytosis to maintain CNS microenvironment by preventing damage from healthy cells. However, mechanism affects phagocytic function of remains unclear. The present study designed investigate effect on...
Aberration during the development of central nervous system (CNS) due to environmental factors underlies a variety adverse developmental outcomes. Paraquat (PQ) is widely studied neurotoxicant that perturbs normal structure/function adult CNS. Yet, impacts PQ exposure on developing CNS remain unclear. miRNAs represent class small non-coding RNA molecules involved in regulation neural development. Thus present study, we analyzed miRNome human progenitor cells (hNPCs) proliferation by using...
To investigate the effect of paraquat (PQ) exposure on gene expression in neural stem cells as well structures and functions vascular endothelial cells.RNA-Seq was used to explore differentially expressed genes human umbilical cord blood-neural (HUCB-NSCs) at different stages (eg, proliferation, early late differentiation) presence PQ. The effects PQ vein (HUVECs), including cell apoptosis, cytokines secretion, tight junction proteins, were assessed with CCK-8, flow cytometry, ELISA, western...
Abstract Data on average iodine requirements for the Chinese population are limited following implementation of long-term universal salt iodisation. We explored minimum young adults in China using a balance experiment and ‘iodine overflow’ hypothesis proposed by our team. Sixty healthy were enrolled to consume sequential experimental diet containing low, medium high levels (about 20, 40 60 μg/d, respectively). Each dose was consumed 4 d, daily intake, excretion retention assessed. All...
To investigate the effect of Yiqihuoxue prescription (YQHX) from Traditional Chinese Medicine (TCM) on myocardial glucose and lipid metabolism after infarction via cross talk between liver kinase B1 (LKB1)-dependent Notch1 adenosine 5'-monophosphate (AMP)-activated protein (AMPK). YQHX was prepared with substances properties that benefit, to activate blood circulation based TCM theory.Animal models were established by ligating Sprague Dawley rats' left anterior descending coronary arteries....
This study aimed to explore the effects of catechin and epicatechin on cognitive deficits oxidative damage mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 200 µT, 30 days). The results showed 90 mg/kg treatment could keep proper body weight compared with ELF-EMF group. Water maze test indicated learning memory abilities group deteriorated significantly control group, but + (catechin epicatechin) improved Malonaldehyde (MDA) nitric oxide (NO) increased...
Silicosis is an occupational disease caused by inhalation of silica dust, which hallmarked progressive pulmonary fibrosis associated with poor prognosis. Wnt/β-catenin signaling implicated in the development and a therapeutic target for fibrotic diseases. Previous clinical studies patients pneumoconiosis, including silicosis, revealed increased concentration circulating WNT3A DKK1 proteins inflammatory cells bronchoalveolar lavage compared healthy subjects. The present study evaluated...
To assess the therapeutic effect of treating diabetic foot ulcers (DFUs) in rats by subcutaneously transplanting around wounds and intramuscularly into leg with bone marrow derived mesenchymal stem cells (BM-MSCs).BM-MSCs from male Wistar were cultured whole adherence method until third generation. The BM-MSCs labeled 4,6-diamino-2-phenylindole (DAPI) vitro. Forty-eight randomly divided 4 groups: group A (n=12), DFUs receiving subcutaneous transplantation; B intramuscular C nondiabetic...
The aim of the present study was to investigate candidate genes and pathways associated with benign prostatic hyperplasia (BPH) diabetes. In vitro experiments were performed using normal epithelial RWPE‑1 HPr‑1 cells. cell lines treated a high‑glucose solution MTS bromodeoxyuridine assays used assess viability. Transcriptome sequencing screen genes. expression further verified by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting. A meiotic recombination...
Silicosis is a lung disease caused by inhalation of silica particles. Both silica-induced oxidative stress and aberrant activation the Wnt/β-catenin signaling pathway are potential targets in treatment pulmonary fibrosis. Dickkopf-1 (Dkk1), an inhibitor pathway, plays regulatory roles cell fate determination immune responses. Our previous study demonstrated that adenoviral vector-mediated
Introduction Macrophages are capable of exerting both proinflammatory and anti-inflammatory functions in response to distinct environmental stimuli, by polarizing into classically inflammatory state (M1) phenotype (M2), respectively. The Wnt/β-catenin signaling plays an important role the tissue homeostasis immune regulations, including macrophage polarizations. However, molecular mechanism regulating alveolar polarization remains unclear. Methods signaling-altered phenotypes murine...
Objective To investigate the changes of hippocampal neurogenesis and cognitive dysfunction induced by cranial radiation therapy.Methods C57BL/6J mice aged 10 d were subjected to Gy whole brain irradiation with 6 MV X-rays develop irradiation-induced injury model.Morris water maze was designed estimate spatial learning memory.At different time post irradiation,brain tissue removed stain hematoxylin-eosin for pathological results.DCX PCNA immunohistochemical staining used mark level in...