A5101902553- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Acute Myocardial Infarction Research
- Neonatal Respiratory Health Research
- Acupuncture Treatment Research Studies
- Blood Pressure and Hypertension Studies
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
- Healthcare and Venom Research
- Cardiac Arrhythmias and Treatments
- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Anesthesia and Neurotoxicity Research
- Immune cells in cancer
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
Qingdao University
2023-2025
Huazhong University of Science and Technology
2025
Soochow University
2025
Xijing Hospital
2022-2025
Air Force Medical University
2023-2025
Yuhuangding Hospital
2023-2025
Beijing Radiation Center
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Zhongnan Hospital of Wuhan University
2022-2024
Yanbian University
2024
Abstract The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need develop novel approaches address problem shortage, particularly for Gram‐negative bacteria. Herein, a biomimetic nanodelivery system proposed enhance bacterial targeting and uptake rifampicin (Rif), traditional but not effective against (Rif@MSN@OMV) composed outer membrane vesicles (OMVs) isolated from E. coli as shell rifampicin‐loaded...
Inflammation induced by intracerebral hemorrhage (ICH) is one of the main causes high mortality and poor prognosis patients with ICH. A1 astrocytes are closely associated neuroinflammation neurotoxicity, whereas A2 neuroprotective. Homer scaffolding protein 1 (Homer1) plays a protective role in ischemic encephalopathy neurodegenerative diseases. However, Homer1 ICH-induced inflammation effect on phenotypic conversion remain unknown.Femoral artery autologous blood from C57BL/6 mice was used...
Although autologous bone (AB) grafting is considered to be the gold standard for cranioplasty, unresolved problems remain, such as surgical-site infections and flap absorption. In this study, an AB scaffold was constructed via three-dimensional (3D) bedside-bioprinting technology used cranioplasty. To simulate skull structure, a polycaprolactone shell designed external lamina, 3D-printed marrow-derived mesenchymal stem cell (BMSC) hydrogel mimic cancellous regeneration. Ourin vitroresults...
Exposure to nickel oxide nanoparticles (NiONPs), which have been widely produced and applied in industry, leads adverse pulmonary systemic effects. The aim of this study is investigate the involvement apoptosis ferroptosis NiONPs-induced acute lung injury (ALI). Intratracheal instillation NiONPs into mice elevated levels pro-inflammatory cytokines, neutrophils, proteins bronchoalveolar lavage fluid, triggered tissues. Consistently, were observed vitro experiments using human epithelial...
Background Both obesity (OB) and periodontitis (PD) are chronic non-communicable diseases, numerous epidemiological studies have demonstrated the association between these two diseases. However, molecular mechanisms that could explain OB PD largely unclear. This study aims to investigate common gene signatures biological pathways in through bioinformatics analysis of publicly available transcriptome datasets. Methods The RNA expression profile datasets (GSE104815) (GSE106090) were used as...
RTS,S is the first malaria vaccine recommended for implementation among young children at risk. However, efficacy modest and short-lived. To mitigate risk of cerebral (CM) under age 5, it imperative to develop new vaccines. EVs are potential candidates as they obtain ability brain-targeted delivery transfer plasmodium antigens immunomodulators during infections. This study extracted from BALB/c mice infected with Plasmodium yoelii 17XNL (P.y17XNL). C57BL/6J were intravenously immunized...
<title>Abstract</title> <bold>Background: </bold>Comorbidities between gastrointestinal tract (GIT) and renal diseases have been widely reported, but the shared genetic architecture of gut traits remains unclear. <bold>Objective: </bold>To investigate etiology causal relationships or involved in gut-renal axis. <bold>Methods</bold>: We explored global local correlations, pleiotropic effects at variants gene levels, associations pair-wise GIT diseases, as well potential target drugs by using...
<title>Abstract</title> Background Urologic cancers continue to present an ongoing challenge human health, underscoring the necessity for a systematic exploration of their underlying mechanisms. Hence, we employed multi-omics Mendelian randomization (MR) approach infer potential pathogenic genes and unravel associated Methods Genome-wide association study (GWAS) summary statistics on urologic cancers, along with expression quantitative trait loci (QTLs), DNA methylation QTLs, protein QTLs...
As mobile phones and communication base stations become more widespread, concerns have arisen regarding the potential risks of environmental exposure to multi-frequency electromagnetic radiation (EMR) its effects on mental health. To address these concerns, our study established a dual-frequency EMR mouse model at 0.8/2.65 GHz explore molecular mechanisms intervention targets. Our results revealed that this significantly induced anxiety-like behavior in mice. Molecular experiments further...
In recent years, high-power microwave (HPM) technology has developed rapidly. However, the current research mainly focuses on how to improve its performance and impact electronic devices, there been relatively little effects organisms. particular, biological of HPMs in X-band is even more limited. The purpose this paper conduct a study with frequency 9.375 GHz mood, learning, cognitive abilities, as well antioxidant defense system. Upon observation, it was noted that mice exposed groups,...
Hyperuricemia (HUA), a condition characterized by elevated levels of uric acid (UA) in the bloodstream, is intricately connected to an imbalance gut microbiota. UA, byproduct purine metabolism, serves as crucial endogenous antioxidant. Recent research indicates that modifying microbiome offers promising avenue for managing HUA. This work delves into complex relationship between HUA and changes microbiota, examining its impact on UA excretion, reabsorption, activity enzymes involved...
Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular cellular levels. Abnormal autophagy apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore alleviative effect underlying mechanism of stem-leaf saponins Panax notoginseng (SLSP) on abnormal neuronal hippocampus mice impaired induced SD.Mouse spatial were assessed Morris water maze test. Neuronal morphological changes observed...
We performed a retrospective analysis involving 1269 patients with atrial fibrillation (AF) to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) on long-term outcomes. The primary outcomes were all-cause mortality and combined end point events (CEEs). Cox proportional hazards regression net reclassification improvement (NRI) performed. During median follow-up 3.32 years, 285 deaths 376 CEEs occurred. With elevation NLR, incidence (2.77, 4.14, 6.12, 12.18/100 person-years)...
Abstract Background Renin–angiotensin–aldosterone-system inhibitors markedly play an active role in the primary prevention of atrial fibrillation (AF), but impact angiotensin-converting enzyme (ACEIs) or angiotensin receptor blockers (ARBs) on mortality patients with AF remains unclear. This study aimed to examine relationship between treatment ACEIs ARBs and emergency department (ED) hypertension. Methods multicenter enrolled 2016 ED from September 2008 April 2011; 1110 hypertension were...
Streptococcus suis ( S. ) is an important food-borne zoonotic pathogen that causes swine streptococcosis, which threatens human health and brings economic loss to the industry. Three-quarters of infections are caused by serotype 2. A retrospective analysis cases in Shenzhen, a megacity China, with high pork consumption, between 2005 2021 was conducted understand its genomic epidemiology, virulence, drug resistance characteristics. The epidemiological investigation showed Shenzhen were mainly...
Intrauterine adhesions caused by damage to the basal layer of endometrium have a serious impact on women's fertility. Currently, there is no effective treatment promote regeneration endometrium. Urinary bladder matrix (UBM) derivative extracellular biomaterial that has complete basement membrane and provides basis for body achieve self-functional repair. In this study, UBM was transplanted into uterine horns intrauterine in Sprague-Dawley rats test whether could improve endometrial with...