Chondrogenic differentiation of mesenchymal stem cells (MSCs) is accurately regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process still remain to be defined. MicroRNAs (miRNAs) regulate various biological processes binding target mRNA attenuate protein synthesis. To investigate for miRNAs-mediated regulation chondrogenic differentiation, we identified that miR-145 was decreased during transforming growth factor beta 3...

Abstract This paper applies exogenous shocks to investigate the impact of digital financial inclusion (DFI) on farmers' poverty vulnerability in China. We find that farmers highly developed DFI areas are less vulnerable trap. The result is robust various checks, including propensity score matching and difference‐in‐differences method instrumental variable approach. Moreover, we income diversification possible economic channel through which affects vulnerability. Further analyses show has a...

MicroRNA-145 has been shown to regulate chondrocyte homeostasis. It seems that miR-145 is implicated in cartilage dysfunction Osteoarthritis (OA). However, the functional role of interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation OA never clarified. Here, we show expression increased chondrocytes and response IL-1β stimulation. We confirm mothers against decapentaplegic homolog 3 (Smad3), a key factor maintaining homeostasis, directly regulated by miR-145. Modulation...

This paper discusses the significance of adolescent depression and anxiety issues their threat to global public health. With development society, age onset for mental health disorders in adolescents has become younger. The World Health Organization (WHO) estimates that 20% worldwide are affected by disorders, including anxiety. These not only limit adolescents' participation social activities but also hinder physical growth. Therefore, this article focuses on several approaches addressing...

Hyperuricemia (HUA), a condition characterized by elevated levels of uric acid (UA) in the bloodstream, is intricately connected to an imbalance gut microbiota. UA, byproduct purine metabolism, serves as crucial endogenous antioxidant. Recent research indicates that modifying microbiome offers promising avenue for managing HUA. This work delves into complex relationship between HUA and changes microbiota, examining its impact on UA excretion, reabsorption, activity enzymes involved...

To treat bone defects, tissue-engineering methods combine an appropriate scaffold with cells and osteogenic signals to stimulate repair. Mesenchymal stem (MSCs) derived from adult marrow are ideal source of for tissue engineering, in particular applications skeletal hard Core binding factor α1 (Cbfa1) is essential transcription osteoblast differentiation. However, the effects Cbfa1 on MSCs vitro vivo have not been well characterized. In this study, we found that modified genetically express...

Introduction Little is known about HIV testing, infection and sexual behaviour among bathhouse patrons in China. This study aims to assess differences prevalence high‐risk behaviours between repeat first‐time testers men who have sex with (MSM) attending Tianjin, Methods Between March 2011 September 2012, a voluntary counselling testing station was established gay bathhouse, which provided conducted survey participants recruited through snowball sampling. Differences demographic were...

Streptococcus suis serotype 2 (SS2) is an important zoonotic bacterial pathogen in both humans and animals, which can cause high morbidity mortality. Meningitis one of the major clinical manifestations SS2 infection. However, specific process meningitis its molecular mechanisms remain unclear. Epidermal growth factor receptor (EGFR) has been reported to initiate transduction intracellular signals regulate host inflammatory responses. Whether how EGFR contributes development S. are currently...

Abstract This study investigated the protective effects of two polysaccharides (CPA‐1 and CPB‐2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity metabolic disorders in rats. Rats were either fed with normal or HF/HFD treated CPA‐1 CPB‐2 (100 300 mg/kg) for 11 weeks. Administration significantly dose dependently reduced body liver weight, insulin glucose tolerance, serum levels. Furthermore, hepatic lipid profiles, function enzymes proinflammatory cytokines...

A popliteal cyst is a benign swelling with synovial fluid located behind the knee joint. Popliteal cysts are often asymptomatic; however, symptomatic may cause pain and need surgery interventions. Here, we performed perspective study to compare clinical efficacy of different surgical approaches, including traditional open excision advanced arthroscopic treatment. total 76 patients were assigned into three groups by randomized complete block design. Group included 32 (15 males 17 females, age...

The primary objective of this study was to explore the association vitamin D with monocyte HDL-C ratio (MHR) among medical staff in Chengdu, China.This cross-sectional involved 538 staff, including 393 females and 145 males, included data on gender, age, body mass index, laboratory parameters (including complete blood count, levels, lipid, etc.). According serum 25 (OH)D < 20 ng/ml as deficiency, subjects were divided into two groups based levels: a deficiency group sufficiency ≥ ng/ml. When...

Bacterial meningitis is currently recognized as one of the most important life-threatening infections central nervous system (CNS) with high morbidity and mortality, despite advancements in antimicrobial treatment. The disruption blood–brain barrier (BBB) induced by bacteria crucial for development bacterial meningitis. However, complete mechanisms involving BBB remain to be elucidated. Here, we found meningitic Escherichia coli induction angiopoietin-like 4 (ANGPTL4) brain microvascular...

SUMMARY Effective viscosity of the upper mantle is a critical parameter for comprehending dynamics lithosphere and plate tectonics. In recent years, magnetotelluric (MT) surveys have gained attention as potential tool determining viscosity. However, direct physical basis relationship between effective electrical resistivity still needs to be improved. To address this issue, we established that connects under different thermochemical conditions principle neutrality. The creep conductions...

The aims of this study were to investigate the effect a mixture bone marrow mesenchymal stem cells (BMSCs) and annulus fibrosus (AFCs) in repairing degenerative discs rabbits, provide an experimental basis for its clinical application.BMSCs from rabbits cultured vitro mixed with AFCs.The animal model intervertebral disc was built by aspirating nucleus pulposus (L3-4, L4-5, L5-6, L6-7) through posterolateral approach.Mixtures BMSCs AFCs (group A), alone (B), or saline (C) injected into test...

China has the highest rail transportation density in world. Compared to other occupational populations, railway workers face increased risk of chronic non-communicable diseases. This study aims investigate relationship between triglyceride-glucose (TyG) index and carotid artery plaque (CAP) a population southwest China.The cross-sectional was conducted among 3169 who were categorized into four groups based on TyG quartiles. The presence CAP assessed using Doppler ultrasound. Logistic...

Metabolic-associated fatty liver disease (MAFLD) is of concern in employed adults, while the crucial indicators predicting MAFLD are understudied this population. We aimed to investigate and compare prediction performance a set for adults.A cross-sectional study recruiting 7968 adults was conducted southwest China. assessed by abdominal ultrasonography physical examination. Comprehensive demographics, anthropometric, lifestyle, psychological, biochemical were collected questionnaire or All...