A5082862974- Dental Health and Care Utilization
- Autism Spectrum Disorder Research
- Gut microbiota and health
- Oral microbiology and periodontitis research
- Genetics and Neurodevelopmental Disorders
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Diet and metabolism studies
- Child Nutrition and Feeding Issues
- Tryptophan and brain disorders
Tongji University
2018-2025
Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental worldwide. However, the role oral in ASD remains unexplored. Via high-throughput sequencing 111 samples 32 children and 27 healthy controls, we demonstrated that salivary dental patients were highly distinct from those individuals. Lower bacterial diversity was observed compared to especially samples. Also, principal coordinate analysis...
Objectives: To assess and compare the oral health status of children with without autism spectrum disorders (ASD) in China. Methods: This study recruited 144 ASD 228 unrelated typical development (TD) aged 3–16 years from Data were collected using parent-reported questionnaires. Oral problems (oral symptoms habits), measures hygiene practice dental care experience), impact on child's quality life (based a modified version Parental-Caregiver Perception Questionnaire) assessed compared between...
Background: Schizophrenia (SZ) is a chronic, severe mental disorder that presents significant challenges to diagnosis and effective treatment. Emerging evidence suggests gut microbiota may play role in the disease's pathogenesis. However, fewer studies have directly investigated potential links between oral SZ. Purpose: This study aimed explore relationship salivary dysbiosis SZ, examining microbial metabolic alterations contribute SZ pathophysiology. Methods: Salivary samples from 30...
Hyperuricemia (HUA), a condition characterized by elevated levels of uric acid (UA) in the bloodstream, is intricately connected to an imbalance gut microbiota. UA, byproduct purine metabolism, serves as crucial endogenous antioxidant. Recent research indicates that modifying microbiome offers promising avenue for managing HUA. This work delves into complex relationship between HUA and changes microbiota, examining its impact on UA excretion, reabsorption, activity enzymes involved...
The oral microbiota has been implicated in various neurologic conditions, including autism spectrum disorder (ASD), a category of neurodevelopmental disorders defined by core behavioral impairments. Recent data propose the etiopathogenetic role intestinal ASD. aim present study was to elucidate whether contributes pathogenesis On basis microbial changes detected cavity children with ASD, we transferred from donors ASD and typical development (TD) into an antibiotic-mediated...
The characteristics of the oral microbiota may depend on health, age, diet, and geography, but influence geographic setting has received limited attention. have been reported to differ between urban rural environments. In order minimize genetic background, we recruited 54 volunteers from same ethnic group, living in areas Gansu Province, China. We collected dental plaque samples divided them into four groups according participant's area residence caries status. sequenced 16S rRNA these using...
Objectives: Autism spectrum disorders (ASD) are neurodevelopmental with changes in the gut and oral microbiota. Based on intimate relationship between microbiota mucosal immunity, this study aimed to investigate salivary immunoglobulin A (IgA) level ASD underlying mechanism for any such changes. Methods: We recruited 36 children diagnosed 35 normally developing measured their IgA content using enzyme-linked immunosorbent assay (ELISA). The valproate (VPA) -treated mouse model was established...