A5036392209- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Arsenic contamination and mitigation
- Trace Elements in Health
- Gestational Diabetes Research and Management
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Metabolomics and Mass Spectrometry Studies
- S100 Proteins and Annexins
- Aluminum toxicity and tolerance in plants and animals
- Tryptophan and brain disorders
- Virology and Viral Diseases
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Central Venous Catheters and Hemodialysis
- Visual perception and processing mechanisms
- Diagnosis and Treatment of Venous Diseases
- Peptidase Inhibition and Analysis
- Glutathione Transferases and Polymorphisms
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Bone and Dental Protein Studies
- Fluoride Effects and Removal
Shenzhen University
2016-2025
Guiyang Medical University
2020-2025
Union Hospital
2017-2025
Huazhong University of Science and Technology
2017-2025
Union Hospital
2024-2025
HKUST Shenzhen Research Institute
2021-2025
Suzhou Municipal Hospital
2012-2024
Nanjing Medical University
2012-2024
First Affiliated Hospital of Dalian Medical University
2017-2024
Dalian Medical University
2017-2024
Affinity-driven selection of B lymphocytes within germinal centers is critical for the development high-affinity memory cells and host protection. To investigate role CD21/CD35 coreceptor in cell competition follicular retention survival center, either Cr2 + or null lysozyme-specific transgenic were adoptively transferred into normal mice immunized with duck (DEL) turkey (TEL) lysozyme, which bind different affinities. In injected responded by retention; however, they could not survive...
Shen, Liming and Garrett E. Alexander. Preferential representation of instructed target location versus limb trajectory in dorsal premotor area. J. Neurophysiol. 77: 1195–1212, 1997. The area (PMd) monkeys has been implicated processes relating to movement preparation selection. In the present study, we sought determine whether PMd neurons that are activated during a delayed reaching task have directional responses reflect either (i.e., goal) an intended or physical properties itself. Two...
Hepatocellular carcinoma (HCC), the primary liver cancer, is one of most malignant human tumors with extremely poor prognosis. The aim this study was to investigate anti-cancer effect berberine in a hepatocellular cell line (HepG2), and underlying mechanisms by focusing on AMP-activated protein kinase (AMPK) signaling cascade. We found that induced both apoptotic autophagic death HepG2 cells, which associated significant activation AMPK an increased expression inactive form acetyl-CoA...
Alzheimer's disease (AD) is a progressive neurodegenerative manifested by cognitive impairment. As unique approach to open the blood-brain barrier (BBB) noninvasively and temporarily, growing number of studies showed that low-intensity focused ultrasound in combination with microbubbles (FUS/MB), absence therapeutic agents, capable ameliorating amyloid or tau pathology, concurrent improving memory deficits AD animal models. However, effects FUS/MB on both two pathologies simultaneously, as...
Oxidative stress has been implicated as a pivotal factor in the pathogenesis of numerous malignancies. However, association between oxidative and prognosis patients with colorectal cancer liver metastasis (CRCLM) is not well elucidated. We conducted retrospective analysis 424 CRCLM who underwent primary resection at Union Hospital, Tongji Medical College, Wuhan, July 2013 September 2018. Patients were randomly divided into training set (n = 300) test 124) 7:3 ratio.To develop...
Shen, Liming and Garrett E. Alexander. Neural correlates of a spatial sensory-to-motor transformation in primary motor cortex. J. Neurophysiol. 77: 1171–1194, 1997. Primary cortex (MC) has been strongly implicated processing, but there have relatively few attempts to determine whether MC may also play role either sensory or context-dependent processing. In the present study, neuronal activity was characterized relation planning execution visually instructed limb movements whose trajectories...
The role of humoral immunity in hepatitis C virus (HCV) infections is uncertain. Nevertheless, there increasing evidence for neutralizing antibodies to HCV the serum or plasma chronically infected individuals. Immune globulins prepared by ethanol fractionation had long been considered safe until a commercial immune globulin product, Gammagard, from which units containing anti-HCV excluded, transmitted recipients. Studies suggested that exclusion might have removed and hence compromised...
Alzheimer’ disease (AD) is the most common form of dementia affecting up to 6% population over age 65. In order discover differentially expressed proteins that might serve as potential biomarkers, serums from AD patients and healthy controls were compared analyzed using proteomics approach isobaric tagging for relative absolute quantitation (iTRAQ). For first time, biomarkers in are investigated Han Chinese iTRAQ labeled strategy. Twenty-two identified out which nine further validated with...
Abstract Cancer is one of the most common incident in world, with malignant tumors having a death rate up to 19%. A new method treating cancer cells effectively minimal cytotoxicity needed. In field biomedicine unique shape-dependent optical properties, gold nanorods (GNRs) have attracted worldwide interest. These two distinct plasmon bands. One transverse band area visible light, and other longitudinal plasmons near infrared region. specific characters provide promise for design optically...
Purpose Autism is a childhood neurological disorder with poorly understood etiology and pathology. This study designed to identify differentially expressed proteins that might serve as potential biomarkers for autism. Experimental design We perform iTRAQ (isobaric tags relative absolute quantitation) analysis normal autistic children's plasma of the same age group. Results The results show 24 were identified between subjects controls. For first time, differential expression complement C5...
Autism is one of the most common neurological developmental disorder associated with social isolation and restricted interests in children. The etiology this still unknown. There neither any confirm laboratory test nor effective therapeutic strategy to diagnose or cure it. To search for biomarkers early detection exploration disease mechanisms, here, we investigated protein expression signatures peripheral blood mononuclear cells (PBMCs) autistic children compared healthy controls by using...
Purpose Gestational diabetes mellitus (GDM) is one of the most common medical problems pregnancy. This study designed to identify serum biomarkers, which can predict subsequent development GDM at early stages. Experimental design Maternal blood was obtained prospectively from pregnant women 12–16 wk Among these, 30 were subsequently diagnosed with 24 28 and selected as case studies along normoglycemic controls. Serum samples analyzed by using iTRAQ analysis. Results Thirty three...
Background: Alzheimer's disease (AD) is the major cause of dementia in population aged over 65 years, accounting up to 70% cases. However, validated peripheral biomarkers for AD diagnosis are not available present. In this study, we adopted a new strategy combination computational prediction and experimental validation identify blood protein AD. Methods: First, collected tissue-based gene expression data patients healthy controls from GEO database. Second, analyzed these identified...
Se-methylselenocysteine (SMC) is a major selenocompound in selenium (Se) enriched plants and has been found to ameliorate neuropathology cognitive deficits triple-transgenic mice model of Alzheimer's disease (3 × Tg-AD mice). To explore the underlying molecular mechanisms, present study designed elucidate protein changes cortex SMC-treated 3 mice. After SMC supplementation, proteomic analysis revealed that 181, 271, 41 proteins were identified as differentially expressed (DEPs) between vs...
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been reported reduce the toxicity of As. In this study, poisoning was simulated by feeding As-containing feed, followed proteomic analysis after one month DIP treatment. showed that 145, 276, 97 proteins were differentially expressed between As-treated rats control (As/Ctrl group), DIP-treated + (DIP As/As As/Ctrl...