Abstract Herein we present a new way to encapsulate neural stem cells (NSCs) by using hydrogen‐bonded organic frameworks (HOFs) overcome the common causes of low therapeutic efficacy during NSC transplantation: 1) loss fundamental cell properties, “stemness”, before transplantation, 2) cytomembrane damage and 3) apoptosis due oxidative stress after transplantation. Porous carbon nanospheres (PCNs) are doped into HOF shell process mineralization endow cellular exoskeletons with hierarchical...

Clearance of peripheral amyloid-β (Aβ) has been demonstrated to be promising for overcoming the blood–brain barrier (BBB) hurdle eliminate brain-derived Aβ associated with Alzheimer's disease (AD). Even so, current developed therapeutic assays clearance are still facing challenges on how avoid interference certain biological molecules and prevent triggering activation immune responses blood clotting. Here, a biomimetic nanozyme (CuxO@EM-K) augmented protein adsorption resistance, minimized...

Phototherapy, such as photodynamic therapy and photothermal therapy, holds great potential for modulation of Alzheimer's β-amyloid (Aβ) self-assembly. Unfortunately, current works phototherapy disease (AD) are just employing either visible or first near-infrared (NIR-I) light with limited tissue penetration, which can not avoid damaging nearby normal tissues AD patients through the dense skull scalp. To overcome shortcomings phototherapy, herein we report an amyloid targeting, N-doped...

Rectifying the aberrant microenvironment of a disease through maintenance redox homeostasis has emerged as promising perspective with significant therapeutic potential for Alzheimer's (AD). Herein, we design and construct novel nanozyme-boosted MOF-CRISPR platform (CMOPKP), which can maintain rescue impaired AD. By modifying targeted peptides KLVFFAED, CMOPKP traverse blood–brain barrier deliver CRISPR activation system precise Nrf2 signaling pathway downstream proteins in regions...

Abstract Adjustable structure, excellent physiochemical properties, and good biocompatibility render polyoxometalates (POMs) as a suitable drug agent for the treatment of Alzheimer's disease (AD). However, previous works using POMs against AD just focus on inhibition amyloid‐β (Aβ) monomer aggregation. In consideration that both Aβ fibrils reactive oxygen species (ROS) are closely associated with clinical development symptoms, it would be more effective if can disaggregate eliminate ROS...

Accumulated Cu in amyloid-β plaques can effectively catalyze the azide–alkyne cycloaddition reaction for fluorophore activation and drug synthesis. Our work may provide new insight into<italic>in situ</italic>drug synthesis neurodegenerative diseases.

Background The etiology of Alzheimer’s disease (AD) is very complex. Docosahexaenoic acid (DHA) important in cognitive ability and nervous system development. A limited number studies have evaluated the efficacy DHA treatment AD. Introduction We detected neurofibrillary tangles (NFT) hippocampus cortex transgenic mice brain through silver glycine staining. determined activity neurons by staining Nissl bodies, used liquid NMR to detect metabolites brain, functional magnetic resonance imaging...

Abstract In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered substantial interest in drug development due to its broad pharmacological activity and multi‐target effects. Diabetes is chronic metabolic disease that can damage multiple organs the body, leading of complications such as abnormal kidney function, vision loss, neuropathy, cardiovascular disease. CBD demonstrated significant therapeutic potential treating diabetes mellitus owing various This work...

This study aimed to investigate the therapeutic effects and molecular mechanisms of SMC on mitochondrial function in 3 × Tg-AD mice.

Alzheimer's disease (AD) is one of the most fatal and irreversible neurodegenerative diseases, which causes a huge emotional financial burden on families society.

Aggregation and cytotoxicity of the amyloid-β (Aβ) peptide with transition metal ions in neuronal cells have been suggested to be involved progression Alzheimer's disease (AD). A therapeutic strategy combat this incurable is design chemical agents target metal–Aβ species. Selenoproteins are a group special proteins that contain 21st amino acid Sec their sequence. Due presence Sec, studies basically focused on roles regulating redox potential scavenging reactive oxygen Here, we reported...

Scope Se‐methylselenocysteine (SMC) is a major selenocompound in selenium (Se)‐enriched plants. Se vital for proper brain function, and Se‐deficient considered to be related with cognitive impairment Alzheimer's disease (AD). The potential of SMC intervening deficits neuropathology triple transgenic AD (3 × Tg‐AD) mice evaluated the first time. Methods results are treated (0.75 mg kg −1 BW per day) their drinking water 10 months. Results reveal that 1) reduces oxidative stress...

Alzheimer's disease (AD) is a widely distributed neurodegenerative characterized clinically by cognitive deficits and pathologically formation of amyloid-β (Aβ) plaque neurofibrillary tangles (NFTs) in the brain. Vanadium biological trace element that has function to mimic insulin for diabetes. Bis(ethylmaltolato) oxidovanadium (IV) (BEOV) been reported have hypoglycemic property, but its effect on AD remains unclear. In this study, BEOV was supplemented at doses 0.2 1.0 mmol/L model mice...

Se-methylselenocysteine (SMC) is a major selenocompound in selenium (Se) enriched plants and has been found to ameliorate neuropathology cognitive deficits triple-transgenic mice model of Alzheimer's disease (3 × Tg-AD mice). To explore the underlying molecular mechanisms, present study designed elucidate protein changes cortex SMC-treated 3 mice. After SMC supplementation, proteomic analysis revealed that 181, 271, 41 proteins were identified as differentially expressed (DEPs) between vs...

Alzheimer's disease (AD) is a neurodegenerative disorder that characterized by peptide and protein misfolding aggregation, in part due to the presence of excess metal ions such as copper. Aggregation cytotoxicity amyloid-β (Aβ) with copper ion have been investigated extensively; however, effects metalation on tau are less known. Here, we presented Cu+ Cu2+ aggregation neurotoxicity second repeat unit microtubule-binding domain (tau-R2). Tau-R2 was demonstrated bind 0.44 0.34 per monomer...

Alzheimer’s disease (AD) is a neurodegenerative with high morbidity that has received extensive attention. However, its pathogenesis not yet been completely elucidated. It mainly related to β-amyloid protein deposition, the hyperphosphorylation of tau protein, and loss neurons. The main function assemble tubulin into stable microtubules. Under pathological conditions, hyperphosphorylated, which major component neurofibrillary tangles (NFT) in AD. There considerable evidence showing...

Identification of the direct molecular targets environmental pollutants is great importance for toxicity mechanism studies. Despite numerous studies have been conducted to investigate perfluorinated compounds (PFCs), their direct-binding protein which trigger downstream effects remain largely unknown. Herein, we present a systematic chemical proteomic study profile target proteins PFCs by taking PFOA as representative. Considering its electrophilicity, could preferentially bind reactive...

Abstract Oxidative stress is the crucial pathologic factor for causing neuron death and cognitive impairment in progression of Alzheimer's disease (AD). As a special antioxidant, molecular hydrogen (H 2 ) responsible alleviating oxidative associated inflammatory symptoms. However, vivo continuous efficient accumulation rather difficult to realize, thus frequent dosing required ensure desired therapeutic effect. Herein, hydrogen‐bonded organic frameworks (HOFs) composites are rationally...

Inhibition of cGAS-STING overactivation has recently emerged as a promising strategy to counteract Alzheimer's disease (AD). However, current inhibitors immunosuppressants suffer from instability, non-specific targeting, and innate immune...