A5048463797- Seaweed-derived Bioactive Compounds
- Alzheimer's disease research and treatments
- Proteins in Food Systems
- Polysaccharides and Plant Cell Walls
- Polysaccharides Composition and Applications
- Pleural and Pulmonary Diseases
- Metal and Thin Film Mechanics
- Pickering emulsions and particle stabilization
- Lung Cancer Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Dialysis and Renal Disease Management
- Congenital Diaphragmatic Hernia Studies
- Biochemical effects in animals
- Echinoderm biology and ecology
- Microencapsulation and Drying Processes
- Aluminum Alloy Microstructure Properties
- Genomics, phytochemicals, and oxidative stress
- Saffron Plant Research Studies
- Antimicrobial Peptides and Activities
- Aluminum Alloys Composites Properties
- Advanced ceramic materials synthesis
- Ginger and Zingiberaceae research
- Plant-derived Lignans Synthesis and Bioactivity
- Ultrasound in Clinical Applications
- Lipid metabolism and biosynthesis
Shenzhen University
2012-2025
Huazhong University of Science and Technology
2023-2024
Union Hospital
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2023
Chongqing Medical University
2021-2023
Committee on Publication Ethics
2023
Creative Commons
2021
Weatherford College
2021
Human Factors (Norway)
2021
China University of Geosciences (Beijing)
2014
Edible berries have a broad spectrum of biomedical functions, including improving immune responses and reducing risk for chronic diseases. In this study, the anti-inflammatory activities crude extracts (CEs), anthocyanin-rich fractions (ARFs), des-anthocyanin (DAFs) from seven were evaluated based on their inhibitory effects nitric oxide (NO) production in lipopolysaccharide (LPS)/IFN-γ-activated RAW264.7 macrophages. ARFs red raspberries (RR-ARFs) exhibited highest efficiency suppressing NO...
MicroRNAs (miRNAs) were recently reported to play an important role in the pathogenesis of pulmonary arterial hypertension (PAH), but it is not clear which miRNAs are or what pathways involved process. Because hypoxia stimulus for human artery smooth muscle cell (HPASMC) proliferation and PAH, we performed miRNA microarray assays hypoxia-treated control HPASMC. We found that miR-210 predominant induced by Induction was also observed whole lungs mice with chronic hypoxia-induced PAH....
Abstract Here, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages and therapeutic efficacy MBF diet mice with dextran sulfate sodium (DSS)-induced acute colitis MUC2 −/− colorectal cancer. In vitro , LPS-induced nitric oxide (NO) production was significantly inhibited by via suppressing expression proinflammatory molecules, including inducible synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1...
Marine seaweed polysaccharides have been considered as a potential resource for antiallergic therapy.
Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition lipid regarded as potential treatment for NAFLD. In this study, we investigated the effects γ-mangostin or α-mangostin on in cell model. Analysis inhibitory revealed that it downregulated NAFLD-related biochemical parameters and stimulated SIRT1/LKB1/AMPK pathway. Consequently, suppressed synthesis enhanced acid oxidation. Moreover, demonstrated blockage AMP-activated protein kinase...
Alzheimer's disease (AD) is a common neurodegenerative which partly characterized by the aggregation of hyperphosphorylated Tau proteins forming neurofibrillary tangles that promote AD pathogenesis. In this study, we investigated effects tanshinone IIA (Tan IIA) isolated from Salvia miltiorrhiza on degradation in treatment AD. The results showed Tan reduced expression and attenuated phosphorylation N2a cells, Tau-overexpressing 3×Tg-AD mouse primary neuron cells. Moreover, increased...
Alginate is a dietary polysaccharide that exerts antioxidative, immunomodulatory and anti-allergic effects. In this study, the effects of alginate on secondary structure ovalbumin (OVA) in vitro regulation OVA-induced gut microbiota disorders vivo were investigated. First, interactions between OVA studied by multiple spectroscopic methods, which showed could change OVA. Then, allergic diarrhoea was evaluated OVA-sensitized mice, demonstrated attenuate duodenal morphological damage....
Polymannuronate (PM) is an acidic polysaccharide prepared from alginate, contained in edible brown seaweeds. An unsaturated mannuronate oligosaccharide (MOS) enzymatically depolymerized PM. The effects of MOS on attenuating tauopathy were studied HEK293/Tau cells and primary triple transgenic (3×Tg) neurons. inhibited heparin-induced aggregation the Tau-K18 oligomer suppressed levels phosphorylated Tau protein. treatment reduced activity glycogen synthase kinase-3β (GSK-3β) by decreasing its...
Food-grade carbohydrate-protein nanoparticles used as stabilizers could satisfy the demands of food, pharmaceutical, and cosmetic industries in terms safety emulsifying function Pickering emulsions. This study aimed to fabricate a new food-grade oligosaccharide-protein nanoparticle by crosslinking soy protein isolate (SPI) chitooligosaccharide (COS) using genipin, then this was applied stabilizer prepare The optimal emulsion preparation conditions were determined be 0.6 φ soybean oil 3 wt%...
Sea cucumbers are valuable marine foods as well a source of traditional medicines with various bioactivities. Macrophage activation by small-molecule oligopeptides obtained from the sea cucumber Apostichopus japonicus (SCOP) were investigated. After SCOP proven nontoxic oral administration and CCK-8 assays, we measured immune-stimulatory mRNA, pro-inflammatory cytokines, NO production levels determined molecular mechanism macrophage stimulation. Our results demonstrated that upregulated both...
Postoperative pneumonia (POP) is one of the most frequent complications following lung surgery. The aim this study was to identify risk factors for developing POP and prognostic in cancer patients after resection.We performed a retrospective review 726 who underwent surgery stages I-III at single institution between August 2017 July 2018 by conducting logistic regression analysis POP. Cox model used analyze influencing survival with cancer.We identified 112 Important included smoking (odds...
Seleno-polymannuronate (Se-PM) was prepared from alginate-derived polymannuronate (PM) through a sulfation followed by selenylation replacement reaction. The organic selenium content of Se-PM 437.25 μg/g and its average molecular weight 2.36 kDa. neuroprotection effect corresponding mechanisms were investigated. Our results showed that, comparing to both sulfated PM (S-PM) PM, remarkably inhibited the aggregation Aβ1-42 oligomer in vitro significantly reduced APP BACE1 protein expression...
Metallothionein (MT1M) belongs to a family of cysteinerich cytosolic protein and has been reported be tumor suppressor gene in multiple cancers.However, its role esophageal carcinoma carcinogenesis remains unclear.In this study, MT1M expression was correlated with type, stage, drinking smoking history, as well patient survival.We also studied the regulation biological function squamous cell (ESCC).We have found that is significantly downregulated ESCC tissues compared adjacent non-cancer...
Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the factors for VTE verify predictive value modified Caprini assessment model (RAM).This prospective single-center study included patients with resectable who underwent resection between October 2019 March 2021. The incidence was estimated. Logistic regression used VTE. Receiver operating...
We aimed to investigate the impact of intraoperative blood loss on postoperative pulmonary complications in patients who underwent video-assisted thoracoscopic lobectomy for nonsmall cell lung cancer.Data a total 409 (227 males, 182 females; median age: 62 years; range, 20 86 years) resection Stage I-IIIa non-small cancer our clinic between July 2017 and April 2018 were retrospectively analyzed. The receiver operating characteristic analysis was used confirm threshold value prediction...
Alzheimer's disease (AD) is a neurodegenerative disorder mainly affecting old population. In this study, two Tau overexpressing cell lines (SH-SY5Y/Tau and HEK293/Tau), N2a/SweAPP line, 3× Transgene (APPswe/PS1M146V/TauP301L) mouse primary nerve were used as AD models to study the activity molecular mechanism of macelignan, natural compound extracted from Myristica fragrans, against AD. Our showed that macelignan could reduce phosphorylation at Thr 231 site, Ser 396 404 site in lines. It...
Chronic kidney disease (CKD) is a substantial global health issue with high morbidity and mortality. Yishen Paidu Pills (YSPDP) are effective concentrated water pills composed of four herbs developed by Wuhan Union Hospital to treat CKD. However, the mechanism YSPDP action largely unknown. This study combined metabolomics, network pharmacology, transcriptomics, experimental verification elucidate identify effects potential mechanisms against