A5013849356- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Organoselenium and organotellurium chemistry
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Selenium in Biological Systems
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
Shenzhen University
2024
University of Chicago
2021-2022
May Institute
2021
Abstract Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one main cell types involved. It is urgent understand interactions among permissive cells, macrophages, and SARS-CoV-2 virus, thereby offering important insights into effective therapeutic strategies. Here, we establish a lung macrophage co-culture system derived from human pluripotent stem cells (hPSCs), modeling host-pathogen interaction in infection....
This study aimed to investigate the therapeutic effects and molecular mechanisms of SMC on mitochondrial function in 3 × Tg-AD mice.
Transdifferentiation is the process of converting terminally differentiated cells to another cell type. Being less time-consuming and free from tumorigenesis, it a promising alternative directed differentiation, which provides sources for tissue regeneration therapy disease modeling. In past decades, transdifferentiation was found happen within or across lineages, being induced by overexpression key transcription factors, chemical cocktail treatments, etc. Implementing next-generation...