A5008054584- Liver physiology and pathology
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Blood Pressure and Hypertension Studies
- Metabolomics and Mass Spectrometry Studies
- Histone Deacetylase Inhibitors Research
- Anesthesia and Sedative Agents
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
- Anesthesia and Pain Management
- Alzheimer's disease research and treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Autism Spectrum Disorder Research
- Nausea and vomiting management
- Multiple Myeloma Research and Treatments
- Traditional Chinese Medicine Analysis
- Cancer, Hypoxia, and Metabolism
- Chromatography in Natural Products
- Neuroscience and Neuropharmacology Research
Zigong First People's Hospital
2025
Shanghai Jiao Tong University
2024
Shanghai First People's Hospital
2021-2024
Shanghai Institute of Materia Medica
2018-2022
Chinese Academy of Sciences
2018-2022
University of Chinese Academy of Sciences
2020-2022
Guangxi Normal University
2022
Xiangya Hospital Central South University
2020
Central South University
2020
Shanghai University of Traditional Chinese Medicine
2013-2017
ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels), and to test relationships between HCN heart brain function. is considered selective blocker currents. Here we show that inhibits not only channel currents, but also Na(+) currents DRG neurons was confirmed inhibit current HEK293 cells transfected with Na(v)1.4 plasmids. Thus our findings challenge view channels. Conclusions about role NCN neuronal function should...
Alzheimer’ disease (AD) is the most common form of dementia affecting up to 6% population over age 65. In order discover differentially expressed proteins that might serve as potential biomarkers, serums from AD patients and healthy controls were compared analyzed using proteomics approach isobaric tagging for relative absolute quantitation (iTRAQ). For first time, biomarkers in are investigated Han Chinese iTRAQ labeled strategy. Twenty-two identified out which nine further validated with...
Purpose Autism is a childhood neurological disorder with poorly understood etiology and pathology. This study designed to identify differentially expressed proteins that might serve as potential biomarkers for autism. Experimental design We perform iTRAQ (isobaric tags relative absolute quantitation) analysis normal autistic children's plasma of the same age group. Results The results show 24 were identified between subjects controls. For first time, differential expression complement C5...
Data sharing within psychiatric and behavioral research represents a novel application of ethical principles in practice; however, it suffers from dearth practical experience established norms. In this study, we comprehensively examined the considerations surrounding acquisition, management, sharing, utilization such data. We graded sensitive data suggest standards for privacy protection based on varying levels sensitivity. The objective study is to foster orderly standardized open data,...
Autism is a severe childhood neurological disorder with poorly understood etiology and pathology. Currently, there no authentic laboratory test to confirm the diagnosis of autism. Oxidative damage may play central role in pathogenesis Present study an effort search for possible biomarkers autism further clarify molecular changes associated oxidative stress that occurs plasma autistic children.We performed redox proteomics analysis compare carbonylated proteins subjects healthy controls....
Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes metabolic status. PGK1 is a catalytic enzyme glycolytic pathway. Here, we set up high-throughput screen platform to identify inhibitors. DC-PGKI an ATP-competitive inhibitor of with affinity Kd = 99.08 nmol/L. stabilizes vitro and vivo, suppresses both activity kinase function PGK1. In addition, unveils that regulates production IL-1β IL-6 LPS-stimulated macrophages. Mechanistically, inhibition...
Psoraleae Fructus is one of the most popular traditional Chinese medicines. Coumarins, flavonoids, and meroterpenes are main contributors to biological activity Fructus. In this study, a new method for quality control was developed, through quantitative analysis multicomponents by single marker with diode array detector. Thirteen components, including psoralenoside, isopsoralenoside, psoralen, isopsoralen, psoralidin, neobavaisoflavone, bavachin, corylin, isobavachalcone, corylifol A,...
Oxidative stress is a key event in the onset and progression of neurodegenerative diseases, including Alzheimer’s disease (AD). To investigate role oxidative AD to search for potential biomarkers peripheral blood, serums were collected this study from 3-, 6-, 12-month-old triple transgenic mice (3×Tg-AD mice) age- sex-matched non-transgenic (non-Tg) littermates. The serum oxidized proteins quantified by slot-blot analysis enzyme-linked immunosorbent assay (ELISA) total levels protein...
The Rho family GTPases are crucial drivers of tumor growth and metastasis. However, it is difficult to develop inhibitors due a lack well-characterized binding pockets for compounds. Here, through molecular dynamics simulation the RhoA protein, groove around cysteine 107 (Cys107) that relatively well-conserved within discovered. Using combined strategy, novel inhibitor DC-Rhoin discovered, which disrupts interaction proteins with guanine nucleotide exchange factors (GEFs) dissociation...
Background It is unclear whether short‐term blood pressure variability associated with renal outcomes in patients chronic kidney disease. Methods and Results This study analyzed data from participants the C‐ STRIDE (Chinese Cohort Study of Chronic Kidney Disease) who had disease stages 1 to 4. Short‐term was measured by calculating weighted SD (w‐ ) systolic ( SBP ). Renal were defined as dialysis initiation and/or transplantation. Risk factors w‐ evaluated linear regression. Associations...
As a final step of the purine metabolism process, xanthine oxidase catalyzes oxidation hypoxanthine and into uric acid. Our research has demonstrated that Erycibe obtusifolia inhibitory properties. The purpose this paper is to describe new strategy based on combination multiple mass spectrometric platforms thin-layer chromatography bioautography for effectively screening antioxidant properties E. obtusifolia. This was accomplished through following steps. (i) Separate extract fractions by an...
Liver fibrosis occurs following inflammation triggered by the integrated actions of activated liver-resident macrophages (Kupffer cells) and hepatic stellate cells (HSCs), multiplicity these mechanisms complicates drug therapy. Here, we demonstrate that selective bromodomain extra-terminal (BET) inhibitor compound38 can block both Janus kinase-signal transducer activator transcription mitogen-activated protein kinase signaling pathways in macrophages, which decreased their secretion...
Background The purpose of this study was to evaluate the relationship between remnant cholesterol (RC) high-density lipoprotein (HDL-C) ratio and risk coronary artery disease (CAD). We also investigated clinical value RC/HDL-C in evaluating severity CAD predicting short-term prognosis patients. Methods In total, 615 patients were enrolled they classified into a group (418 cases) normal (197 according results angiography. Serum Gensini score calculated. Multivariate logistic regression...
Abstract An ionic liquid, 1‐butyl‐3‐methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]) was introduced as dynamic coating of a silica monolithic column for capillary electrochromatography phenols and nucleoside monophosphates. The run‐to‐run column‐to‐column repeatability migration time six were satisfactory on this with relative standard deviation values less than 0.90 4.31%, respectively. Anodic electroosmotic flow (EOF) observed, which increased the increase [BMIM][BF ] concentration...
Small molecular inhibitors targeting BRD4 family proteins are emerging as promising therapies in many types of human malignancies. However, whether BRD4, well other BET members, may serve therapeutic targets renal cell carcinoma (RCC) remains unknown. In this study, we found that both BRD2 and were over-expressed RCC tissues, knock-down which achieved potent anti-proliferative effects cells. A novel category inhibitors, originated from an approved drug Nitroxoline, synthesized evaluated with...
Plants of Erycibe are widely used in traditional Chinese medicine for the treatment joint pain and rheumatoid arthritis. With reduction resources wild, Porana sinensis has been as a substitute. However, it is important to understand chemical distinctions between two kinds plants identify their individual markers. In this study, multiwavelength chromatographic fingerprint precursor ion techniques were conjunction with chemometric tools thus differentiate plant samples. The similar results...
Hepatic fibrosis, a common pathological manifestation of chronic liver injury, is generally considered to be the end result an increase in extracellular matrix produced by activated hepatic stellate cells (HSCs). The aim present study was target mechanisms underlying HSC activation order provide powerful therapeutic strategy for prevention and treatment fibrosis. In study, high‑throughput screening assay established, histone deacetylase inhibitor givinostat identified as potent <em>in...