A5101728316- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Estrogen and related hormone effects
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Phytoestrogen effects and research
- Biological Activity of Diterpenoids and Biflavonoids
- Alkaloids: synthesis and pharmacology
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Reproductive System and Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Medicinal Plant Pharmacodynamics Research
- Andrographolide Research and Applications
- Natural Antidiabetic Agents Studies
- Food Quality and Safety Studies
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Bioactive Compounds
- Bioactive natural compounds
- Medicinal Plant Extracts Effects
- Sperm and Testicular Function
- Mass Spectrometry Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Ionic liquids properties and applications
Shanghai University of Traditional Chinese Medicine
2013-2023
Shanghai Institute of Materia Medica
2022
Chinese Academy of Sciences
2022
Yale University
2016
Abstract Morus alba L has long been used as fodder and a traditional medicine. The different parts of M. (Cortex Mori, Ramulus Folium Mori Fructus Mori) have bioactivities; however, most current evidence is focused on anti‐diabetic properties. In spite their widespread use, few studies compared the chemical composition activity against α ‐glucosidase various medicinal . this study, we developed an HPLC method for simultaneous quality control discrimination Cortex using 13 marker compounds....
Abstract The Chinese herbal preparation QiBaoMeiRan formula (QBMR) displayed estrogenic effects in ovariectomized rats after long-term administration a previous study. uterus and vagina are negatively influenced by estrogens hormone therapy. While QBMR is known to be phytoestrogen, its safety on reproductive tissues short-term mechanism via estrogen receptor (ER) pathway haven’t been studied. Here, we characterized using immature mice together with vitro studies for further molecular...
Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy limited. In this study, we characterized estrogenic activity using in vivo models immature and ovariectomized (OVX) mice performed vitro studies focusing on receptor (ER) pathway further molecular characterizations. treatments demonstrated significant by promoting development uterus vagina mice, restoring estrus cycle reversing...
Erycibe obtusifolia and E. schmidtii are widely used in traditional Chinese medicine (TCM) to treat joint pain rheumatoid arthritis. With the reduction of wild resources, Porana sinensis has been as a substitute. However, few studies have conducted on chemical composition quality control P. sinensis.To clarify improve sinensis.We developed an ultra-high performance liquid chromatography electrospray ionisation Q-Exactive Focus tandem mass spectrometry (UHPLC-ESI-Q-Exactive Focus-MS/MS)...
The increasing popularity of traditional Chinese medicines (TCMs) necessitates rapid and reliable methods for controlling their quality. Direct analysis in real-time mass spectrometry (DART-MS) represents a novel approach to analysing TCMs.To develop quick method identifying TCMs with coumarins as primary characteristics.DART-MS coupled ion trap was employed rapidly identify characteristics explore the ionisation mechanisms simple coumarins, furocoumarins pyranocoumarins detail. With minimal...
An accurate and reliable analytical method for-simultaneous determination of six active components (scopolin, chlorogenic acid, scopoletin, isochlorogenic acid A, B C) in plants Erycibe was developed.Scopolin, C the samples were well separated HPLC by gradual elution with methanol-0.1% formic solution. The chromatographic condictions: Agilent Poroshell 120 EC-C18 column, flowing rate being 1 mL x min(-1), detecting wavelength at 345 nm.Good linearities scopolin, range 0.026 8-2.68, 0.027...
Radix paeoniae alba (RPA) and Veratrum nigrum (VN) L. belong to the 18 incompatible medicaments have been prohibited for thousands of years in China. Previous studies focused on chemical constituents that induced toxicological response two agents, but this study offers preliminary insight into pharmacodynamics mechanism estrogenic activity, which is responsible their incompatibility. We undertook a characterization interaction activity RPA VN using vivo models immature ovariectomized (OVX)...
It has been considered as a crucial field for the extraction of active ingredients from herbal medicine to use green and efficient method in medicinal food industries. In this study, deep eutectic solvent (DES) coupled with microwave-assisted (MAE) was used extract ten compounds Eucommia ulmoides leaves. Response surface methodology (RSM) combined Box-Behnken design (BBD) optimize conditions using MAE method. An anti-solvent efficiently recovered target analytes DES. By combining DES-based...