A5100729491- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Advanced Proteomics Techniques and Applications
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Polymer composites and self-healing
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- CRISPR and Genetic Engineering
- Asymmetric Synthesis and Catalysis
- Plant Stress Responses and Tolerance
- Nerve injury and regeneration
- Hepatocellular Carcinoma Treatment and Prognosis
- Mass Spectrometry Techniques and Applications
- Plant Molecular Biology Research
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Sirtuins and Resveratrol in Medicine
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
Peking University People's Hospital
2021-2025
Peking University
2011-2025
UC San Diego Health System
2025
Beijing Institute of Technology
2022-2024
University of Dundee
2020-2024
Second Affiliated Hospital of Harbin Medical University
2018-2024
Harbin Medical University
2018-2024
Institute of Mountain Hazards and Environment
2012-2024
Chinese Academy of Sciences
2014-2024
Fudan University
2024
Abstract In this minireview, squaramides are presented from their roots as artificial anion receptors in molecular recognition studies to recent advances powerful bifunctional hydrogen‐bonding catalysts asymmetric organocatalysis. The main features of the squaramido functionality and direct comparison with analogous ureas thioureas also discussed.
GO-PEI-Au-L-Cys composites were synthesized via loading gold nanoparticles on a GO surface using polyethylenimine as reducing and stabilizing reagents, followed by L-cysteine immobilization through an Au-S bond. The applied kind of novel ZIC-HILIC material to achieve highly selective enrichment glycopeptides from biological samples.
Solid oxide fuel cells (SOFCs) offer a significant advantage over other in terms of flexibility the choice fuel. Ammonia stands out as an excellent for SOFCs due to its easy transportation and storage, carbon-free nature mature synthesis technology. For direct-ammonia (DA-SOFCs), development anode catalysts that have efficient catalytic activity both NH3 decomposition H2 oxidation reactions is great significance. Herein, we develop Mo-doped La0.6Sr0.4Fe0.8Ni0.2O3−δ...
Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring polyphenolic compound highly enriched in grapes, peanuts, red wine, and variety of food sources. has antiinflammatory antioxidant properties, also potent anticancer properties. Human glioma U251 cells were used to understand the molecular mechanisms by which resveratrol acts as an agent, since particularly difficult cancer treat eradicate. Our data show that induces dose- time-dependent death cells, measured lactate...
Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in variety of cancers. In the present study, antitumor effect and underlying molecular mechanism Res on rat C6 glioma growth was studied. The results demonstrated that inhibited cell proliferation, arrested cycle S phase induced apoptosis vitro. also suppressed intracranial tumor vivo prolonged survival fraction rats bearing gliomas. significantltly downregulated specific miRs, including miR‑21, miR‑30a-5p miR‑19,...
Ultrafast laser drilling has been proven to effectively reduce the heat-affected zone (HAZ) of carbon fiber-reinforced polymer (CFRP) composites. However, previous research mainly focused on effects picosecond parameters CFRP drilling. Compared with a laser, femtosecond can achieve higher quality due its smaller pulse width, but there are few studies Moreover, cross-sectional taper produced by is very large. This paper introduces use drill cylindrical holes in CFRP. The effect power,...
Accurate prediction of treatment response to transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) is critical for precision treatment. This study aimed develop a comprehensive model (DLRC) that incorporates contrast-enhanced computed tomography (CECT) images and clinical factors predict the TACE HCC.A total 399 intermediate-stage HCC were included this retrospective study. Deep learning radiomic signatures established based on arterial phase CECT images,...
Abstract Understanding how chromatin organisation is duplicated on the two daughter strands a central question in epigenetics. In mammals, following passage of replisome, nucleosomes lose their defined positioning and transcription contributes to re-organisation. However, whether plays greater role organization DNA replication remains unclear. Here we analysed protein re-association with newly replicated upon inhibition using iPOND coupled quantitative mass spectrometry. We show that...
In their previous studies, the authors found that simvastatin treatment of traumatic brain injury (TBI) in rats had beneficial effects on spatial learning functions. current study they wanted to determine whether suppressed neuronal cell apoptosis after TBI, and if so, examine underlying mechanisms this process.Saline or (1 mg/kg) was administered orally starting Day 1 TBI then daily for 14 days. Modified Neurological Severity Scores were used evaluate sensory motor functional recovery. Rats...
OBJECTIVE In this study, we investigated the effects of simvastatin on proliferation, migration, and apoptosis in human U251 U87 glioma cells underlying molecular mechanism. METHODS We used colony formation assay to test cell vitro scratch examine caspase-3 activity assay, annexin V staining, cytochrome C release evaluate apoptosis. Lipid raft fractions were isolated from cells. Total cholesterol content was change level lipid fractions. Immunocytochemistry staining performed detect changes...
X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby transcription from one repressed. Analysis of human induced pluripotent stem cells (iPSCs) derived donors identified that low levels XIST RNA correlated strongly with erosion XCI. Proteomic analysis, sequencing (RNA-seq), and polysome profiling showed XCI resulted amplified protein expression X-linked genes, providing proteomic characterization skewed compensation. Increased was also detected...
The long non-coding RNA LINC00467 plays a vital role in many malignancies. Nevertheless, the of prostate carcinoma (PC) is unknown. Herein, we aimed to explore mechanism by which regulates PC progression. We used bioinformatics analyses and RT-qPCR investigate expression tissues cells. function progression was confirmed loss-of-function experiments. cell proliferation assessed CCK-8 EdU assays. cycle cells examined flow cytometry. Moreover, Transwell assays were migration invasion Western...
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA-bound proteins, it is unclear how they regain access newly replicated DNA. Using quantitative proteomics coupled Nascent Capture or isolation Proteins on DNA, we provide time-resolved binding kinetics for thousands proteins behind replisomes within euchromatin heterochromatin human cells. This shows that most...
Introduction:Cyclocarya paliurus (Batal.) Iljinsk., a subtropical tree belonging to the family Juglandaceae, is rich in polysaccharides, flavonoids, and terpenoids. It has important pharmacological effects such as lowering blood lipids, sugar, pressure. However, little been discerned regarding anti tumor their potential mechanisms. Method:In vitro cell culture experiments were used test effect of C. total flavonoids (CTFs) extract on apoptosis mechanisms HepG2 cells. Network pharmacology was...
To establish a prediction model for the efficacy of neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC), using pretreatment magnetic resonance imaging (MRI) multisequence image features and clinical parameters.Patients clinicopathologically confirmed LARC were included (training validation datasets, n = 100 27, respectively). Clinical data collected retrospectively. We analyzed MRI features. The tumor regression grading (TRG) system proposed by Mandard...
FAM111A is a replisome-associated protein and dominant mutations within its trypsin-like peptidase domain are linked to severe human developmental syndrome, the Kenny–Caffey syndrome. However, functions remain unclear. Here, we show that facilitates efficient activation of DNA replication origins. Upon hydroxyurea treatment, FAM111A-depleted cells exhibit reduced single-stranded formation better survival rate. Unrestrained expression WT patient mutants causes accumulation damage cell death,...
Male and female poplar ( Populus cathayana Rehd.) cuttings respond differently to salinity stress. To understand these differences better, comparative morphological, physiological, proteomics analyses were performed. Treatments with different concentrations of NaCl applied male for 4 weeks showed that females reacted more negatively at the morphological physiological levels than did males, visible as shriveled leaves, decreased growth, lowered photosynthetic capacities, greater Na(+)...