A5032943821- Lichen and fungal ecology
- Heat shock proteins research
- Cancer-related gene regulation
- Toxin Mechanisms and Immunotoxins
- Polar Research and Ecology
- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Signaling Pathways in Disease
- Enzyme Structure and Function
- Marine and coastal plant biology
- Endoplasmic Reticulum Stress and Disease
- Synthesis and Catalytic Reactions
- Adipose Tissue and Metabolism
- Bacterial Genetics and Biotechnology
- Metabolomics and Mass Spectrometry Studies
- Protein Kinase Regulation and GTPase Signaling
- RNA and protein synthesis mechanisms
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Botany and Plant Ecology Studies
- Protein Structure and Dynamics
- Pharmacogenetics and Drug Metabolism
- Enzyme function and inhibition
- Eicosanoids and Hypertension Pharmacology
- Peptidase Inhibition and Analysis
Harbin Institute of Technology
2014-2024
Hubei University of Chinese Medicine
2024
China University of Mining and Technology
2023-2024
Binzhou People's Hospital
2021
People’s Hospital of Rizhao
2018
Polar Research Institute of China
2018
Chifeng University
2018
Cornell University
2018
Laboratoire Informatique d'Avignon
2010
University of Pennsylvania
2010
The ethanol-inducible cytochrome P450 2E1 (CYP2E1) is also induced under different pathological and physiological conditions. Studies including ours have shown that CYP2E1 bimodally targeted to both the endoplasmic reticulum (microsomes) (mc CYP2E1) mitochondria (mt CYP2E1). In this study we investigated role of mtCYP2E1 in ethanol-mediated oxidative stress stable cell lines expressing predominantly mt or mc CYP2E1. ER+ mutation (A2L, A9L), which increases affinity nascent protein for...
The diversity of lichen fungal components and their photosynthetic partners reflects both ecological evolutionary factors. In present study, molecular investigations the internal transcribed spacer nuclear ribosomal DNA (ITS nrDNA) region were conducted to analyze genetic Umbilicaria esculenta U. muehlenbergii together with associated green algae. It was here demonstrated that reproductive strategy is a principal reason for selectivity muehlenbergii, which disperses via sexual spores,...
Despite the immense success of immune checkpoint blockade (ICB) in cancer treatment, many tumors, including melanoma, exhibit innate or adaptive resistance. Tumor-intrinsic T-cell deficiency and dysfunction have been identified as essential factors emergence ICB Here, we found that protein arginine methyltransferase 1 (PRMT1) expression was inversely correlated with number activity CD8+ T cells within melanoma specimen. PRMT1 inhibition DCPT1061 significantly restrained refractory growth...
Trigger factor (TF) is the first chaperone encountered by nascent chain in bacteria and forms a stoichiometric complex with ribosome. However, functional significance of high cytosolic concentration uncomplexed TF, majority which dimeric, unknown. To gain insight into TF function, we investigated dependence glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reactivation yield presence absence DnaK-DnaJ-GrpE system vitro. Cross-linking results indicate that observed decrease GAPDH at...
The Rho family GTPases are crucial drivers of tumor growth and metastasis. However, it is difficult to develop inhibitors due a lack well-characterized binding pockets for compounds. Here, through molecular dynamics simulation the RhoA protein, groove around cysteine 107 (Cys107) that relatively well-conserved within discovered. Using combined strategy, novel inhibitor DC-Rhoin discovered, which disrupts interaction proteins with guanine nucleotide exchange factors (GEFs) dissociation...
Depression is one of the major psychiatric diseases affecting quality life for individuals worldwide. Numerous reports have investigated depression, although its etiology remains to be elucidated. microRNA (miR)‑146a suggested regulate innate immune and inflammatory responses. However, it unclear whether miR‑146a involved in depression. model mice were established using lipopolysaccharide‑induced depression chronic unpredictable mild stress, separately. mimic short interfering RNA used treat...
At present, due to the increasing pressures on society and stress of everyday living, number individuals suffering from depression has increased. Therefore, treatment also received attention. MicroRNA (miRNA/miR)‑135a is a well‑studied miRNA. It been reported that miR‑135a significantly downregulated in patients with may be potential marker for diagnosis condition. However, specific mechanisms action remain unclear. In present study, it was found depression, mouse model depression. The...
To investigate the molecular chaperone function of trigger factor (TF) and its relationship with isomerase activity in vivo, assisted folding adenylate kinase (AK) by TF Escherichia coli was examined measuring amounts soluble AK produced during co‐expression. When mutant chicken AK, P17G, is expressed plasmid pBVAK, 95% protein found inclusion bodies. Co‐expression achieved using a pBVAT that allowed expression same under separate control. resulted an increase amount higher when at levels...
Abstract Lichens, as typical obligate associations between lichenized fungi and their photosynthetic partners, are dominant in Antarctica. Three Antarctic lichens, Ochrolechia frigida, Umbilicaria antarctica, Usnea aurantiacoatra with different growth forms, were sampled nearby the Great Wall Station, King George Island. Molecular data revealed that algae these three lichens Trebouxia jamesii. The net photo− synthesis (Pn) of individuals from species, together environmental factors such...
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The single celled green alga Coccomyxaantarctica Shunan Cao & Qiming Zhou, sp. nov. was isolated from the Antarctic torrential lichen Usneaaurantiacoatra (Jacq.) Bory. It is described and illustrated based on a comprehensive study of its morphology, ultrastructure, ecology phylogeny. C.antarctica lichenicolous which has elongated cells contains parietal chloroplast as observed under microscope. clearly different other species by phylogenetic analysis (ITS rDNA SSU sequences), also it...
Musclin is a muscle-secreted cytokine that disrupts glucose uptake and glycogen synthesis in type 2 diabetes. The purpose of this study was to investigate the mechanisms responsible for regulation musclin gene expression response treatment with palmitate. RNA sequencing results showed biological processes activated by palmitate are mainly enriched endoplasmic reticulum (ER) stress. protein kinase RNA-like ER (PERK) signaling pathway involved induced Chromatin immunoprecipitation data...
Reduced denatured lysozyme tends to aggregate at neutral pH and competition between productive folding aggregation substantially reduces the efficiency of refolding. Trigger factor, a catalyst chaperone can, depending on concentration trigger factor solution conditions, cause either substantial increase (chaperone activity) or decrease (antichaperone in recovery native as compared with spontaneous When is working chaperone, reactivation rates are decelerated decreases increasing...