A5003934005- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Folate and B Vitamins Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Colorectal and Anal Carcinomas
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- S100 Proteins and Annexins
- Virus-based gene therapy research
- Computational Drug Discovery Methods
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2017-2025
Kite (United States)
2025
Shandong University of Traditional Chinese Medicine
2017-2025
Ningxia Medical University
2013-2025
Gilead Sciences (United States)
2023-2025
Chengdu Medical College
2022-2024
Shandong First Medical University
2019-2024
University of Electronic Science and Technology of China
2024
Shandong Tumor Hospital
2021-2024
Ruijin Hospital
2024
Abstract c-Myc (Myc) plays an important role in normal liver development and tumorigenesis. We show here that Myc is pathologically activated essential for promoting human hepatocellular carcinoma (HCC). induces HCC through a novel, microRNA (miRNA)-mediated feedback loop comprised of miR-148a-5p, miR-363-3p, ubiquitin-specific protease 28 (USP28). directly binds to conserved regions the promoters two miRNAs represses their expression. miR-148a-5p targets inhibits Myc, whereas miR-363-3p...
miRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether how it plays a role the laryngeal carcinoma is unknown. Mature expression cancer was detected by qRT-PCR. Gain-of-function studies using mature miR-27a were performed to investigate cell proliferation apoptosis Hep2 cells. In silico database analysis luciferase reporter assay applied predict validate direct target, respectively. Loss-of-function assays functional significance of...
Lung adenocarcinoma (LUAD) is a very common and lethal kind of lung malignancy. An increasing number studies indicated that tissue-resident memory T (TRM) cells played significant roles in anti-cancer immunity. In our previous study, EXO1 was found to be core gene for TRM the prognosis LUAD. However, tumor microenvironment, its application diagnosis prediction LUAD are still inadequately explored. this RNA expression, DNA methylation, CNV, somatic mutation data EXO1, corresponding patients'...
Purpose The coagulation process and infiltration of macrophages affect the progression prognosis lung adenocarcinoma (LUAD) patients. This study was designed to explore novel classification methods that better guide precise treatment LUAD patients on basis macrophages. Methods Weighted gene coexpression network analysis (WGCNA) applied identify M2 macrophage-related genes, TAM marker genes were acquired through scRNA-seq data. MSigDB KEGG databases used obtain coagulation-associated genes....
CAR T cell therapy provided transformative outcomes for patients with B-cell lymphoma; however, a large fraction of remains at risk relapse, underlying the need to uncover mechanisms resistance and predictive biomarkers. Herein, we leveraged ZUMA-7 phase III randomized trial relapsed/refractory lymphoma (LBCL) treated axicabtagene ciloleucel (axi-cel; CD19-targeting cells) discover tumor gene expression signatures (GES) associated outcome. With transcriptomics from 134 axi-cel patients,...
Abstract The UK Biobank study has produced thousands of brain imaging-driven phenotypes (IDPs) collected from more than 40,000 genotyped individuals so far, facilitating the investigation genetic and imaging biomarkers for disorders. Motivated by efforts in genetics to integrate gene expression levels with genome-wide association studies (GWASs), recent methods adopted an instrumental variable (IV) approach identify causal IDPs However, several methodological challenges arise existing...
Building on results from the AELIX-002 trial with HIVACAT T-cell immunogen (HTI)-based vaccines, AELIX-003 (NCT04364035) tested safety of combination ChAdOx1.HTI (C) and MVA.HTI (M), TLR7 agonist vesatolimod (VES), in a double-blind, placebo-controlled, randomized clinical 50 virally suppressed early-treated men HIV-1 infection. Secondary objectives included immunogenicity effects viral rebound kinetics during 24-week antiretroviral treatment interruption (ATI). The most common...
Dysregulation of c-Myc (Myc) has been shown to contribute progression hepatocellular carcinoma, however, the detailed molecular mechanism remains poorly understood. Here, we report that Myc binds Aurora kinase A (Aurka) promoter and induces expression Aurka in HCC cells. Increased correlates with HCC. Nuclear accumulation was confirmed by subcellular protein fractionation immunoblot experiments inhibition decreases nuclear Also accumulating nucleus up-regulates transcription binding...
Background: This study was designed to explore the implications of ferroptosis-related alterations in glioblastoma patients. Method: After obtaining data sets CGGA325, CGGA623, TCGA-GBM, and GSE83300 online, extensive analysis mutual verification were performed using R language-based analytic technology, followed by further immunohistochemistry staining utilizing clinical pathological tissues. Results: The revealed a substantial difference expression genes between malignant paracancerous...
In the PINETREE study, early remdesivir treatment reduced risk of coronavirus disease 2019 (COVID-19)-related hospitalizations or all-cause death versus placebo by 87% day 28 in high-risk, non-hospitalized patients. Here we report results assessment heterogeneity effect (HTE) outpatient remdesivir, focusing on time from symptom onset and number baseline factors (RFs).PINETREE was a double-blind, placebo-controlled trial patients with COVID-19 who were randomized within 7 days had ≥ 1 RF for...
Background Strains of Staphylococcus aureus with an intermediate level resistance to vancomycin (vancomycin-intermediate S. aureus, or VISA) which contain subpopulations mixed susceptibility (heterogeneous VISA, hVISA) have been reported worldwide. However, the prevalence VISA and hVISA infections in Northeast China is unknown. From 2007 through 2010, we surveyed methicillin-resistant methicillin-sensitive (MRSA MSSA, respectively) clinical isolates China. Methods (369 MRSA 388 MSSA) were...
The dysregulation of microRNAs (miRNAs) contributes to the pathogenesis human malignancies, and miRNA expression can be affected by genetic epigenetic changes, such as methylation CpG islands their promoters. To identify miRNAs regulated DNA methylation, global profile was analyzed in two hepatocellular carcinoma (HCC) cell lines normal immortalized treated with 5-Aza-2'-deoxycytidine (DAC, an inhibitor methylation) plus TSA (Trichostatin A, histone deacetylase inhibitor). Results revealed...
The diversity of lichen fungal components and their photosynthetic partners reflects both ecological evolutionary factors. In present study, molecular investigations the internal transcribed spacer nuclear ribosomal DNA (ITS nrDNA) region were conducted to analyze genetic Umbilicaria esculenta U. muehlenbergii together with associated green algae. It was here demonstrated that reproductive strategy is a principal reason for selectivity muehlenbergii, which disperses via sexual spores,...
pvl gene
Gastric cancer is the second most common cause of cancer-related deaths in world. Although certain dietary factors and lifestyles have been suggested to be associated with gastric carcinogenesis, there few investigations focusing on rural areas. A case-control study was therefore carried out investigate risk cardia (GCC) areas Linzhou. total 470 newly diagnosed cases GCC healthy controls were included. Face-to-face interviews conducted, using a uniform questionnaire containing questions...