A5101580912- Retinal Diseases and Treatments
- Voice and Speech Disorders
- Metal complexes synthesis and properties
- Glaucoma and retinal disorders
- Organometallic Compounds Synthesis and Characterization
- Cancer-related molecular mechanisms research
- Photoreceptor and optogenetics research
- Cancer Mechanisms and Therapy
- Dysphagia Assessment and Management
- Light effects on plants
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Imaging and Diagnostics
- Retinal Imaging and Analysis
- MicroRNA in disease regulation
- Synthesis and Characterization of Heterocyclic Compounds
- Protist diversity and phylogeny
- Neurological Disease Mechanisms and Treatments
- Ocular Oncology and Treatments
- Endometrial and Cervical Cancer Treatments
- Respiratory Support and Mechanisms
- Traditional Chinese Medicine Analysis
- Ovarian function and disorders
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Photosynthetic Processes and Mechanisms
Second Affiliated Hospital of Nanchang University
2011-2025
Nanchang University
2011-2025
Institute of Applied Ecology
2025
Chinese Academy of Sciences
2025
Guangxi Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2024
South China Normal University
2021-2023
Louisiana State University Health Sciences Center Shreveport
2023
Inner Mongolia University for Nationalities
2019-2023
Henan Normal University
2022
Chondrogenic differentiation of mesenchymal stem cells (MSCs) is accurately regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process still remain to be defined. MicroRNAs (miRNAs) regulate various biological processes binding target mRNA attenuate protein synthesis. To investigate for miRNAs-mediated regulation chondrogenic differentiation, we identified that miR-145 was decreased during transforming growth factor beta 3...
Pefloxacin has been increasingly used in veterinary medicine to treat microbial infections. To avoid using a labor-intensive instrumental method detect the residue of pefloxacin food, simple and convenient indirect competitive enzyme-linked immunosorbent assay developed this study. The antibody generated from immunogen cationized bovine serum albumin−pefloxacin showed high sensitivity toward with an IC50 value 6.7 ppb buffer was suitable for screening food products. assessed rapid enzyme...
To investigate the effect of glucose transporter-1 (GLUT1) inhibition on diabetic retinopathy, we divided forty-eight mice into scrambled siRNA, and GLUT1 siRNA (intravitreally injected) groups. Twenty-one weeks after diabetes induction, calculated retinal concentrations, used electroretinography (ERG) histochemical methods to assess photoreceptor degeneration, conducted immunoblotting, leukostasis vascular leakage assays estimate microangiopathy. The exhibited higher concentrations than but...
During our systematic study on the anticancer activities of Scutellaria barbata, scutebarbatine A (SBT-A), one major alkaloids in S. was found to have antitumor effects A549 cells. Thus, we designed present investigate detail SBT-A. The cytotoxic effect SBT-A vitro were determined by an MTT assay and evaluated IC50 values. Furthermore, results Hoechst 33258 Annexin V/PI staining assays demonstrated that had significant cells via apoptosis, a concentration-dependent manner. What’s more,...
Choroidal melanoma is a rare yet aggressive ocular malignancy, accounting for approximately 85% of all melanomas. This study aimed to investigate the association between treatment modalities and risk all-cause mortality choroidal melanoma-specific mortality, thereby comparing effects different on patient prognosis. Data from patients diagnosed with 2004 2021 were extracted Surveillance, Epidemiology, End Results (SEER) database. A total 6,871 cases included in analysis. Univariate analysis,...
MicroRNA-21 (miR-21) was reported to act as an oncogene during the development of many human tumors. However, little revealed about function miR-21 in retinoblastoma (RB). In this study, we examined expression RB tissues and explored relationship between phosphatase tensin homolog (PTEN)/phosphatidylinositol-3-OH kinase (PI3K)/AKT signal. Quantitative real-time PCR (qRT-PCR) results showed that level higher than retinal normal tissues. Weri-Rb-1 cells, inhibitor suppressed cell viability,...
Tetramethylpyrazine (TMP) has been widely used in China as a drug for the treatment of various diseases. Recent studies have suggested that TMP protective effect on ischemic neuronal damage. However, exact mechanism is still unclear. This study aims to investigate mediated hippocampal neurons injury induced by oxygen-glucose deprivation (OGD). The viability was detected MTT assay, LDH release assay and apoptosis rate measured flow cytometry. significantly suppressed neuron...
Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore,...
A polyclonal anti-gatifloxacin antibody has been prepared, and an indirect competitive enzyme-linked immunosorbent assay (cELISA) was developed on the basis of prepared for first time. The shows high sensitivity with IC50 value 2.6 ppb excellent specificity only a minor cross-reaction lomefloxacin (3.0%) among common (fluoro)quinolones evaluated in this study. explained by molecular structures related drugs comparison published research. cELISA test kit detection limit 0.05 could be used as...
To observe the effect of inhibiting long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on diabetic neurodegeneration.Thirty-six 8-week-old C57BL/6 mice were randomly divided into normal control, scrambled small interfering RNAs (siRNAs) and MALAT1-siRNA groups. After induction with streptozocin intraperitoneally-injection, group was intravitreally injected µL 20 µmol/L MALAT1 siRNA, siRNA same amount siRNA. Electroretinography performed to examine...
Purpose: Intricate signaling networks and transcriptional regulators translate pathogen recognition into defense responses. The aim of this study was to identify the weighted genes involved in diabetic retinopathy (DR) different rodent models diabetes. Methods: We performed a gene coexpression analysis publicly available microarray data, namely, GSE19122 dataset from Gene Expression Omnibus database. conducted on data modules functionally related coexpressed that are differentially expressed...
A novel type of circadian and photoperiodic control the cell division cycle was found in photoautotrophic Euglena gracilis. When algae entrained to 24 h light–dark (LD) cycles (14 L) were transferred continuous darkness (DD) at eighth hour final LD photoperiod, cell-cycle transition arrested phase G1, S or G2. The subsequent exposure these dark-arrested cells a 6 light-break allowed undergo progression DD, manner dependent on phase; maximum photoinduction occurred around dusk. Inhibitor...
The aim of the present study was to investigate effect homocysteine (Hcy) in on human trabecular meshwork cells (HTMCs). A total 41 patients with primary open-angle glaucoma (POAG) and 53 senile cataracts (control group) were recruited. Plasma aqueous humor samples collected Hcy concentrations determined using enzymatic cycling assays. In cell experiments, normal HTMCs passaged randomly divided into a blank control group, HTMC group experimental groups, which treated different Hcy....
Patients with COVID-19 generally raise antibodies against SARS-CoV-2 following infection, and the antibody level is positively correlated to severity of disease. Whether viral exacerbate through antibody-dependent enhancement (ADE) still not fully understood. Here, we conducted in vitro assessment whether convalescent serum enhanced infection or induced excessive immune responses cells. Our data revealed that primary B cells, macrophages monocytes, which express variable levels FcγR, could...
To explore the diagnosis value of colposcope combined with serum squamous cell carcinoma antigen (SCC-Ag), carbohydrate 125 (CA125), and carcinoembryonic (CEA) for moderate to advanced cervical cancer patients treated modified Fuzheng Peiyuan decoction.The clinical data 43 in Suzhou Hospital Traditional Chinese Medicine from July 2018 2019 were selected retrospective analysis, healthy women undergoing physical examination our medical center same period as control group. The accepted...
Abdominal aortitis can induce aneurysms, and tumor rupture lead to organ ischemia or even sudden death. At present, there is a lack of extensive understanding identification key problems in the treatment abdominal aortitis, which needs be further analyzed using bibliometric analysis.
The present study aimed to investigate the effect of forskolin on retinal inflammation under diabetic conditions. C57BL/6 mice were randomly divided into normal control, control and treatment groups. model was established by intraperitoneal injection streptozotocin. group received intragastrical administration for 12 weeks, other two groups an equal amount PBS. At 21 weeks following induction, immunoblotting test conducted expression inflammatory factors: Intercellular adhesion molecule-1...
Retinoblastoma is a malignant tumor of the developing retina that mostly occurs in children. Our study aimed to investigate effect tripartite motif-containing protein 59 (TRIM59) on retinoblastoma growth and underlying mechanisms.We performed bioinformatic analysis three datasets (GSE24673, GSE97508, GSE110811) from Gene Expression Omnibus database. Quantitative reverse-transcription PCR immunoblotting cell lines were conducted verify TRIM59 as differentially expressed gene. Specific siRNAs...