A5103116596- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Genetics and Biotechnology
- Nanoplatforms for cancer theranostics
- Plant Pathogenic Bacteria Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Urinary Tract Infections Management
- Legionella and Acanthamoeba research
- Enterobacteriaceae and Cronobacter Research
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Microbial Metabolism and Applications
- Antibiotic Use and Resistance
- Drug-Induced Hepatotoxicity and Protection
- Oral microbiology and periodontitis research
- Nanoparticle-Based Drug Delivery
- Infections and bacterial resistance
Southwest Hospital
2016-2025
Army Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2025
Chongqing Medical University
2021-2025
Sichuan Agricultural University
2024-2025
Clinical Trial Investigators
2024
Emerald Coast Science Center
2024
Southwest General Health Center
2020-2022
Chongqing University
2020-2021
Army Medical College
2019
The study aimed to perform a systematic investigation of the effects quercetin on biofilm formation and virulence factors in Pseudomonas aeruginosa.The Ps. aeruginosa strain PAO1 was selected as test strain. results indicated that did not impact growth determined by MIC curve analysis. However, this compound significantly inhibited (P < 0·05) production including pyocyanin, protease elastase at lower concentration than those for most previously reported plant extracts substances. Considering...
Abstract Background Migraine, a neurological disorder with significant female predilection, is the leading cause of disability-adjusted life years (DALYs) in women childbearing age (WCBA). There currently lack comprehensive literature analysis on overall global burden and changing trends migraines WCBA. Methods This study extracted three main indicators, including prevalence, incidence, DALYs, related to migraine WCBA from Global Burden Disease(GBD) database 1990 2021. Our presented point...
Immunocompromised individuals and those with lung dysfunction readily acquire pulmonary bacterial infections, which may cause serious diseases carry a heavy economic burden. Maintaining adequate antibiotic concentrations in the infected tissues is necessary to eradicate resident bacteria. To specifically deliver therapeutics enable controlled release of payloads at infection site, ROS-responsive material, i.e. 4-(hydroxymethyl) phenylboronic acid pinacol ester-modified α-cyclodextrin...
The emergence of multidrug-resistant Klebsiella pneumoniae, including carbapenem-resistant K. pneumoniae (CRKP), as one the most common and notable superbugs, has long been a major threat to public health. As natural predators bacteria, bacteriophages (or phages) can induce lysis bacterial cells. Herein, we report isolation characterization two phages their efficacy in control CRKP. Using sequence type 11 (ST11) CRKP strain THR60 its related THR60r host GZ7 GZ9 were isolated from hospital...
ABSTRACT Biofilm formation in Staphylococcus epidermidis is mediated by icaADBC -dependent and -independent pathways. Subinhibitory concentrations of erythromycin, azithromycin, clarithromycin enhanced, a dose-dependent manner, the level biofilm 20% (21/105 isolates) macrolide-resistant ica -positive -negative isolates tested vitro . The presence , however, apparently produced an enhanced effect on formation. levels expression biofilm-related genes icaA atlE fruA pyrR sarA sigB were...
Although stimuli-responsive nanoplatforms were developed to deliver immunogenic cell death (ICD) inducers enhance cancer immunotherapy, the complete release of ICD into tumor microenvironment (TME) was limited by inadequate supplementation endogenous stimulus (e.g., reactive oxygen species (ROS)). To address this issue, we synthesized a self-responsive nanomaterial with self-supplied ROS, which mainly consists ROS responsive moiety HPAP and cinnamaldehyde (CA) as ROS-generating agent. The...
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes clinical diagnosis pharmacotherapy. Several classifications have been proposed on the basis clinical, genetic, alcoholic, or serum metabolic analyses. Yet, accurately predicting progression to cirrhosis hepatocellular carcinoma (HCC) in patients challenge. Here, Chinese cohort patients, we classified into three distinct molecular...
Pseudomonas aeruginosa strain 10265 was recovered from a patient with pneumonia in Chinese public hospital, and it displays the carbapenem resistance phenotype due to acquisition of non-conjugative but mobilizable IncP-6-type plasmid p10265-KPC. p10265-KPC carries Tn5563-borne defective mer locus, novel ΔISEc33-associated bla KPC-2 gene cluster without paired inverted repeats direct at both ends. Mobilization this element would be attributed homologous recombination-based insertion foreign...
Abstract A total of 26 bla IMP-4 -carrying strains Pseudomonas aeruginosa and Klebsiella pneumoniae were isolated from 2009 to 2013 in a Chinese teaching hospital, these can be assigned into multiple sequence types or allelic profiles as determined by multilocus typing. Of strains, P. P378 K. 1220 harbor the IMP-4-encoding plasmids pP378-IMP p1220-IMP, respectively, whose complete nucleotide sequences are genetically closely related IncN1-type plasmid pIMP-HZ1. pP378-IMP/p1220-IMP-like...
Vibrio parahaemolyticus, a leading cause of seafood-associated diarrhea and gastroenteritis, harbors three major virulence gene loci T3SS1, Vp-PAI (T3SS1+tdh2) T6SS2. As showing is this study, the nucleoid-associated DNA-binding regulator H-NS binds to multiple promoter-proximal regions in each above repress their transcription, moreover inhibits cytotoxicitiy, enterotoxicity, hemolytic activity, mouse lethality V. parahaemolyticus. appears act as repressor pathogen.
Background AphA is the master quorum-sensing (QS) regulator operating at low cell density in vibrios. Molecular regulation of target genes by has been characterized Vibrio harveyi and V. cholerae, but it still poorly understood parahaemolyticus. Methodology/Principal Findings The proteins are extremely conserved parahaemolyticus, sp. Ex25, EJY3, harveyi, vulnificus, splendidus, anguillarum, furnissii. above nine orthologs appear to recognize cis-acting DNA signals which can be represented...
Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, which harbor conjugative plasmids pYNKP001-NDM pP10164-NDM, respectively, were isolated from two different Chinese patients, their complete nucleotide sequences determined. Production of NDM-1 enzyme by these accounts for the carbapenem resistance strains. This is first report bla NDM in L. third this gene R. ornithinolytica. very similar to IncN2 NDM-1-encoding pTR3, pNDM-ECS01, p271A, whereas pP10164-NDM IncFIIY...
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility low bioactivity of Lut restrict its clinical translation. Herein, we developed reactive oxygen species (ROS)-responsive nanoplatforms to improve Lut. Folic acid (FA) was employed decorate nanoparticles (NPs) enhance targeting ability. The size Lut-loaded ROS-responsive (Lut/Oxi-αCD NPs)...
Radiation-induced colitis is a serious clinical problem worldwide. However, the current treatment options for this condition have limited efficacy and can cause side effects. To address issue, colon-targeted fullerenol@pectin@chitosan gel microspheres (FPCGMs) are developed, which aggregate on colon tissue long time, scavenge free radicals generated in process of radiation, regulate intestinal flora to mitigate damage colonic tissue. First, FPCGMs exhibit acid resistance release properties,...
Due to the high mortality rate in chicks caused by pullorum disease (PD) and drawbacks of antibiotic resistance, poultry industry is increasingly interested using natural herbal antimicrobial agents as alternatives, with cinnamaldehyde (CA) being a focus due its multitarget synergistic effects. This study aimed evaluate effects oral administration CA on restoring intestinal physical integrity, microbial barrier, metabolism laboratory model Salmonella (S. pullorum) infection chicks....
This study aimed to investigate the effects of polymyxin B (PMB) in combination with other antibiotics on delaying resistance Klebsiella pneumoniae and explore mechanisms underlying PMB-induced resistance. In vitro continuous induction experiments were performed observe changes drug susceptibility PMB alone versus combination. RNA-seq, qRT-PCR, proteomic analyses utilized evaluate differential gene protein expression between induced-resistant strains those exhibiting delayed Then, knockout...