A5101610981- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
- Machine Learning in Bioinformatics
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Escherichia coli research studies
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Aquaculture disease management and microbiota
- Viral Infections and Immunology Research
- Vibrio bacteria research studies
- Surgical Sutures and Adhesives
- Bioinformatics and Genomic Networks
- Long-Term Effects of COVID-19
- Antioxidant Activity and Oxidative Stress
- Cervical Cancer and HPV Research
- Hemostasis and retained surgical items
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Tracheal and airway disorders
Westlake University
2025
Neijiang Normal University
2024
Southwest Medical University
2023-2024
Shenzhen Center for Disease Control and Prevention
2012-2024
Qingdao University
2024
Qingdao Women and Children's Hospital
2024
Huazhong University of Science and Technology
2023-2024
Ningbo Medical Center Lihuili Hospital
2024
Ningbo University
2024
First Affiliated Hospital of GuangXi Medical University
2017-2023
Skin wounds accompanied by massive bleeding and bacterial infection can be life-threatening pose a significant challenge to clinical wound management. Herein, we prepared gellan gum/sericin hydrogels containing PDA-encapsulated halloysite nanotubes (halloysite@polydopamine) achieve fast hemostasis photothermally antibacterial effects. The morphology compressive properties of the composite were characterized, biocompatibility was investigated hemocompatibility cytocompatibility tests....
Abstract Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics combat bacterial has led emergence multi-drug-resistant bacteria. Therefore, there is pressing need for alternative approaches, such as photothermal therapy (PTT), address this issue. In study, first time, CuS NPs with properties were synthesized using sericin biological template, named CuS@Ser NPs. This method simple, green, does not produce...
Bone defects caused by trauma, tumor resection, or developmental abnormalities are important issues in clinical practice. The vigorous development of tissue engineering technology provides new ideas and directions for regenerating bone defects. Hydroxyapatite (HAp), a bioactive ceramic, is extensively used because its excellent osteoinductive performance. However, application challenged single function conventional environment-unfriendly synthesis methods. In this study, we successfully...
We analyzed the prevalence and characteristics of Vibrio parahaemolyticus among patients with acute infectious diarrhea in southern coastal region China. V. was leading cause bacterial this during 2007-2012. Serotype O3:K6 strains were most common, followed by serotypes O4:K8 O3:K29.
To explore a potential expansion of the phenotypic and genotypic characteristics Finnish variant late-infantile neuronal ceroid lipofuscinosis (NCL), we screened collection 47 patients with clinically diagnosed NCL in whom no molecular diagnosis had been made.We used PCR amplification genomic DNA, followed by fluorescent-labeled dideoxy-nucleotide chain termination sequencing multiplex ligation-dependent probe amplification, to screen our cohort for mutations CLN5. We collected ethnic...
Klebsiella pneumoniae is well-known opportunistic enterobacteria involved in complex clinical infections humans and animals. The domestic animals might be a source of the multidrug-resistant virulent K. to humans. are considered as an emergent global concern. horizontal gene transfer plays essential roles bacterial genome evolution by spread virulence resistance determinants. However, genes can transferred horizontally via pneumoniae-derived outer membrane vesicles (OMVs) remains unreported....
Currently, bone marrow mesenchymal stem cells (BMSCs) have been reported to promote endometrial regeneration in rat models of mechanically injury-induced uterine adhesions (IUAs), but the therapeutic effects and mechanisms hypoxic BMSC-derived exosomes on IUAs not elucidated.
ABSTRACT Background Progressive external ophthalmoplegia (PEO) is a classic manifestation of mitochondrial disease. However, the link between its genetic characteristics and clinical presentations remains poorly investigated. Methods We analysed clinical, pathological large cohort patients with PEO, based on type their mtDNA variations. Eighty‐two PEO were enrolled grouped into three categories: single large‐scale deletions (SLDs), multiple (MulDs) m.3243A > G point variant. Patients in...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide and one deadliest cancers in Asia. But at present, effective targets for HCC clinical therapy are still limited. The "guilt by association" rule suggests that interacting proteins share same or similar functions hence may be involved pathway. This assumption can used to identify disease related genes from protein association networks constructed existing PPI data. Given close between Hepatitis B virus which lead...
Observing what phenotype the overexpression or knockdown of gene can cause is basic method investigating functions. Many advanced biotechnologies, such as RNAi, were developed to study phenotype. But there are still many limitations. Besides time and cost, some may be lethal which makes observation other phenotypes impossible. Due ethical technological reasons, genes in complex species, mammal, extremely difficult. Thus, we proposed a new sequence-based computational called k NNA-based for...
Abstract Background The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis in human is still under investigation. aim this study was explore relationship between Th17-mediated and airway inflammation childhood asthma. Methods Twenty-eight children with exacerbated without using any glucocorticoids were divided into three groups: eosinophilic (EA, n = 12) group, (NA, 10) group paucigranulocytic...
The ongoing COVID-19 pandemic caused by SARS-CoV-2 is a huge public health crisis for the globe. receptor-binding domain (RBD) of spike (S) protein plays vital role in viral infection and serves as major target developing neutralizing antibodies. In this study, antibody response to RBD S was analyzed panel sera from animals immunized with RBD-based antigens four linear B-cell epitope peptides (R345, R405, R450 R465) were revealed. immunogenicity three immunodominant further accessed peptide...
Streptococcus suis ( S. ) is an important food-borne zoonotic pathogen that causes swine streptococcosis, which threatens human health and brings economic loss to the industry. Three-quarters of infections are caused by serotype 2. A retrospective analysis cases in Shenzhen, a megacity China, with high pork consumption, between 2005 2021 was conducted understand its genomic epidemiology, virulence, drug resistance characteristics. The epidemiological investigation showed Shenzhen were mainly...
Noncompressible wounds resulting from accidents and gunshots are typically associated with excessive bleeding, slow wound healing, bacterial infection. Shape-memory cryogel presents great potential in controlling the hemorrhaging of noncompressible wounds. In this research, a shape-memory was prepared using Schiff base reaction between alkylated chitosan (AC) oxidized dextran (ODex) then incorporated drug-laden silver-doped mesoporous bioactive glass (MBG). Hydrophobic alkyl chains enhanced...
Background The study was designed to access the feasibility, safety, and efficacy of fully covered self-expandable metal stents in treatment bronchial fistula. Methods Clinical data nine patients (seven males two females) who were treated with placement tracheobronchial or from August 2005 November 2011 analyzed retrospectively. Among these patients, seven diagnosed bronchopleural fistula, one tracheopleural left main bronchoesophageal Eight had accompanying thoracic empyema. fistula...