A5102882655- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Antioxidants, Aging, Portulaca oleracea
- Cardiac Ischemia and Reperfusion
- Blood disorders and treatments
- Medicinal Plants and Bioactive Compounds
- Connective tissue disorders research
- Cancer, Lipids, and Metabolism
- Advanced battery technologies research
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Cardiac Health and Mental Health
- Genetics and Neurodevelopmental Disorders
- Multiple Myeloma Research and Treatments
- Ophthalmology and Eye Disorders
- Acute Myeloid Leukemia Research
- Coenzyme Q10 studies and effects
- Cardiovascular and exercise physiology
- Folate and B Vitamins Research
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
Qilu Hospital of Shandong University
2010-2025
Shandong University
2010-2014
Second Hospital of Shandong University
2011
Ministry of Education of the People's Republic of China
2010
Summary Introduction: CIP2A is a newly identified inhibitor of PP2A. It can stabilize c‐Myc and promote anchorage‐independent cell growth tumour formation. over‐expressed in some solid tumours although its expression acute myeloid leukaemia (AML) still unknown. Methods: mRNA protein expressions were determined bone marrow mononuclear cells both patients with AML healthy controls using reverse transcription polymerase chain reaction Western blot, respectively. We used siRNA to knock‐down HL60...
ABSTRACT Background Progressive external ophthalmoplegia (PEO) is a classic manifestation of mitochondrial disease. However, the link between its genetic characteristics and clinical presentations remains poorly investigated. Methods We analysed clinical, pathological large cohort patients with PEO, based on type their mtDNA variations. Eighty‐two PEO were enrolled grouped into three categories: single large‐scale deletions (SLDs), multiple (MulDs) m.3243A > G point variant. Patients in...
Mitochondrial tRNA (mt-tRNA) variants have been found to cause disease. Post-transcriptional queuosine (Q) modifications of mt-tRNA can promote efficient mitochondrial mRNA translation. Q mt-tRNAAsn recently identified. Here, the therapeutic effectiveness queuine was investigated in cells from patients with variants. Six (from four families) carrying were included study. Queuine levels quantified by mass spectrometry. Clinical, genetic, histochemical, biochemical, and molecular analysis...
Background Obesity abolishes anesthetic pre‐conditioning‐induced cardioprotection due to impaired reactive oxygen species ( ROS )‐mediated adenosine monophosphate‐activated protein kinase AMPK ) pathway, a consequence of increased basal myocardial oxidative stress. Exercise training has been shown attenuate obesity‐related Objective This study tests whether exercise could normalize ‐mediated pathway and prevent the attenuation in obesity. Methods Male S prague– D awley rats were divided into...
Abstract Background Mitochondrial diseases (MDs) can be caused by single nucleotide variants (SNVs) and structural (SVs) in the mitochondrial genome (mtDNA). Presently, identifying deletions small to medium-sized fragments accurately detecting low-percentage remains challenging due limitations of next-generation sequencing (NGS). Methods In this study, we integrated targeted long-range polymerase chain reaction (LR-PCR) PacBio HiFi analyze 34 participants, including 28 patients 6 controls....