A5014998705- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Pharmacological Effects of Natural Compounds
- Genetic Neurodegenerative Diseases
- Connective tissue disorders research
- Phytoestrogen effects and research
- Acute Ischemic Stroke Management
- Thyroid Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Spine and Intervertebral Disc Pathology
- Pregnancy and preeclampsia studies
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Spinal Cord Injury Research
- Genetics and Neurodevelopmental Disorders
- Traditional Chinese Medicine Analysis
- Neurological disorders and treatments
- ATP Synthase and ATPases Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Medicinal Plants and Neuroprotection
- Maternal and fetal healthcare
- RNA Research and Splicing
Qilu Hospital of Shandong University
2019-2025
First Affiliated Hospital of Kunming Medical University
2020-2024
Kunming Medical University
2013-2024
Baotou Medical College
2024
Inner Mongolia University of Science and Technology
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Wenzhou Medical University
2024
Liaoning University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Zhengzhou University
2017-2022
Interactions between astrocytes and microglia play an important role in the regeneration repair of traumatic brain injury (TBI), exosomes are involved cell–cell interactions. A TBI model was constructed rats. Brain extract (Ext) isolated 1 d after TBI. Astrocyte-derived were obtained by coculturing Ext with primary astrocytes, morphology observed electron microscopy. The cocultured to observe phenotypic changes M1 M2 markers. Aberrant RNA expression detected necrotic tissue edematous tissue....
To explore the mechanism by which Remazolam affects phenotype and function of astrocytes to improve traumatic brain injury (TBI). The oxygen -glucose deprivation/recovery (OGD/R) cell model was constructed simulate pathological state in a TBI environment. viability measured CCK-8, cytoskeleton changes were observed Phalloidin- TRITC staining. expressions differentiation markers, Cx43 phosphorylated (P-Cx43) A1/A2 detected Western blot, complement C3 S100A10 ELISA. rat established. water...
ABSTRACT Background Progressive external ophthalmoplegia (PEO) is a classic manifestation of mitochondrial disease. However, the link between its genetic characteristics and clinical presentations remains poorly investigated. Methods We analysed clinical, pathological large cohort patients with PEO, based on type their mtDNA variations. Eighty‐two PEO were enrolled grouped into three categories: single large‐scale deletions (SLDs), multiple (MulDs) m.3243A > G point variant. Patients in...
Metabolic syndrome (MS) is a leading cause of mortality and morbidity in Western countries.
Both early correction of anemia and preserving residual renal function (RRF) are reported to improve patient survival. The aim this study was explore the efficacy safety Roxadustat for treatment in patients new peritoneal dialysis (PD) assess its impact on RRF.A retrospective analysis performed 60 initial with anemia. Twenty-eight cases were treated (Roxadustat group) 32 recombinant human erythropoietin (control group). Clinical characteristics, hemoglobin (Hb), C-reactive protein, blood...
To explore the clinical characteristics of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) caused by DNA-encoded complex I subunit (mt-ND) variants.In this retrospective study, clinical, myopathological brain MRI features patients with MELAS mt-ND variants (MELAS-mtND) were collected compared those carrying m.3243A > G variant (MELAS-A3243G).A total 18 MELAS-mtND (female: 7; median age: 24.5 years) represented 15.9% (n = 113) all mtDNA in our neuromuscular...
Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In study, 25 patients with traumatic > 6 months) were treated human umbilical blood stem cells via intravenous intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions restored latent somatosensory evoked potentials...
To evaluate the impact of bleomycin/etoposide/cisplatin (BEP) and paclitaxel/carboplatin (PC) chemotherapy regimens on fertility prognostic outcomes in malignant ovarian germ cell tumor (MOGCT) patients who underwent fertility-sparing surgery (FSS).A propensity score matching algorithm was performed between BEP PC groups. The χ² test Kaplan-Meier method were used to compare outcome, disease-free survival (DFS) overall (OS). Cox proportional hazards regression analysis identify risk factor...
This study was aimed at investigating the correlation between occurrence of stroke and relative fat mass (RFM), a novel metric for determining total body fat.
Heart failure (HF) is a clinical syndrome caused by the progression of various cardiac diseases to severe stages, and exercise training plays positive role in development HF. This study aimed investigate impact different intensities on HF rats.In this study, we established two rat models intraperitoneal injection isoproterenol at 2.5 mg/kg/day abdominal aortic coarctation. After for 4 weeks, heart weight/body weight ratio echocardiography results were measured. Moreover, regulatory effect...
Mitochondrial tRNA (mt-tRNA) variants have been found to cause disease. Post-transcriptional queuosine (Q) modifications of mt-tRNA can promote efficient mitochondrial mRNA translation. Q mt-tRNAAsn recently identified. Here, the therapeutic effectiveness queuine was investigated in cells from patients with variants. Six (from four families) carrying were included study. Queuine levels quantified by mass spectrometry. Clinical, genetic, histochemical, biochemical, and molecular analysis...
Abstract Aim To explore whether neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte (MLR) could predict missed abortion (MA) at 7–13 week's gestation. Methods A total of 363 women with a diagnosis MA 232 normal pregnancy gestation, who visited our hospital from June 2012 to May 2018 were retrospectively analyzed. At 7 differential leukocyte counts, NLR MLR compared between ( n = 69) controls 53). The receiver operating characteristic curve was used select the optimal indicator...
Background: We investigated the role of balloon placement in abdominal aorta (BPAA) planned conservative management placenta previa with increta or percreta and effects BPAA on perinatal adverse maternal events. Methods: This retrospective case-control study included women (increta percreta), who underwent pregnancy termination at Qilu Hospital Shandong University between January 2016 June 2019. Patients were categorized into non-BPAA groups based before delivery. The Chi-square...
In general, spinal cord injury without radiological abnormality (SCIWORA) with spondylosis is considered to be a central injury. This article describes the clinical features and surgical outcomes of atypical in patients spondylotic SCIWORA (ACCISS). Fifty-two were enrolled study from January 2006 December 2011. Diagnoses made imaging (computed tomography, magnetic resonance imaging) findings. The neurologic status was assessed using American Spinal Injury Association (ASIA) score Japanese...
Background Individuals recovering from stroke often experience cognitive and emotional impairments, but rehab programs tend to focus on motor skills. The aim of this investigation is systematically assess the change magnitude function subsequent a conventional rehabilitative protocol administered survivors within defined locale in China.
Abstract Background Coronary microvascular dysfunction (CMD) often accompanies diabetes mellitus (DM), leading to myocardial ischemia despite normal or mildly narrowed coronary arteries (&lt;50% stenosis). CMD causes hypoperfusion, resulting in impaired systolic function. flow reserve (CFR) serves as a marker of function, particularly the absence significant epicardial stenosis. Myocardial contrast echocardiography (MCE) is key tool for clinically assessing CFR. Global longitudinal...