A5100372377- Stress Responses and Cortisol
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Plant Physiology and Cultivation Studies
- Immune Cell Function and Interaction
- Perovskite Materials and Applications
- Quantum Dots Synthesis And Properties
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
- Genetics and Neurodevelopmental Disorders
- Immune Response and Inflammation
- Neuroendocrine regulation and behavior
- Animal Genetics and Reproduction
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Reproductive Biology and Fertility
- Esophageal Cancer Research and Treatment
- Genetic and Kidney Cyst Diseases
- Ubiquitin and proteasome pathways
Shenzhen University
2025
Shandong University of Traditional Chinese Medicine
2025
Taiyuan University of Technology
2021-2025
National Clinical Research
2024
Tianjin Medical University Cancer Institute and Hospital
2020-2024
First Affiliated Hospital of Soochow University
2016-2024
Soochow University
2016-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2024
Jingning County People's Hospital
2024
Hebei University of Chinese Medicine
2022-2024
Mutations in Parkin, an E3 ubiquitin ligase that regulates protein turnover, represent one of the major causes familial Parkinson disease, a neurodegenerative disorder characterized by loss dopaminergic neurons and impaired mitochondrial functions. The underlying mechanism which pathogenic Parkin mutations induce abnormality is not fully understood. Here, we demonstrate interacts with subsequently ubiquitinates dynamin-related 1 (Drp1), for promoting its proteasome-dependent degradation....
Abstract Naturally occurring CD4 + CD25 regulatory T cells (Treg) exert an important role in mediating maternal tolerance to the fetus during pregnancy, and this effect might be regulated via estrogen secretion. Although concentration pharmaceutical range has been shown drive expansion of Treg cells, little is known about how through what mechanisms E2 within physiological pregnancy affects expansion. Using vivo vitro mouse models these experiments, we observed that at doses not only...
Caprin-1 is a ubiquitously expressed, well-conserved cytoplasmic phosphoprotein that needed for normal progression through the G1-S phase of cell cycle and occurs in postsynaptic granules dendrites neurons. We demonstrate colocalizes with RasGAP SH3 domain binding protein-1 (G3BP-1) RNA associated microtubules concentrated leading trailing edge migrating cells. exhibits highly conserved motif, F(M/I/L)Q(D/E)Sx(I/L)D binds to NTF-2-like G3BP-1. The carboxy-terminal region selectively bound...
We have recently described a new subfamily of Fox genes, Foxp1/2/4, which are transcriptional repressors and thought to regulate important aspects development in several tissues, including the lung, brain, thymus heart. Here, we show that Foxp1 is expressed myocardium as well endocardium developing To further explore role cardiac development, inactivated through gene targeting embryonic stem cells. mutant embryos severe defects morphogenesis, outflow tract septation cushion defects, thin...
Despite recent encouraging developments, achieving efficient blue perovskite light-emitting diodes (PeLEDs) have been widely considered a critical challenge. The efficiency breakthrough only occurred in the sky-blue region, and device performance of pure-blue deep-blue PeLEDs lags far behind those their counterparts. To avoid negative effects associated with dimensionality reduction excess chloride typically needed to achieve emission, here we demonstrate guanidine (GA+)-induced (∼457 nm)...
Abstract Tin‐based perovskite solar cells (TPSCs) have attracted significant research interest due to their exceptional optoelectronic properties and environmentally friendly characteristics. However, TPSCs with ideal bandgap suffer from substantial current losses, necessitating the development of innovative interface engineering strategies enhance device performance. In this study, an unprecedented approach constructing charge transfer path is presented by a simple post‐growth treatment...
The importance of ubiquitin E3 ligases in neurodegeneration is being increasingly recognized. crucial role NEDD4-1 neural development well appreciated; however, its remains unexplored. Herein, we report increased expression the degenerated tissues several major neurodegenerative diseases. Moreover, upregulated cultured neurons response to various neurotoxins, including zinc and hydrogen superoxide, via transcriptional activation likely mediated by reactive oxygen species (ROS)-responsive...
Objectives and methods With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders set in three ways: model0 (including age, height, weight, smoking drinking), model1 (model0 +regular physical activity) model2 (model1 +medication treatments). The eBMD was derived heel...
Darier's disease (DD), a rare hereditary acantholytic dermatosis with high penetrance but variable expressivity, has about 10% of its cases presenting as localized lesions, known Localized Disease (LDD). To date, only very small number non-segmental LDD have been reported. This study reports case 27-year-old Chinese male LDD, who presented yellow-brown papules and plaques on the inner side right thigh for 1 month. The diagnosis keratosis follicularis was confirmed through dermatoscopic...
The present study aimed to develop a nomogram model for predicting overall survival (OS) in esophageal squamous cell carcinoma (ESCC) patients. A total of 205 patients with ESCC were enrolled and randomly divided into training cohort (n = 153) test 52) at ratio 7:3. Multivariate Cox regression was used construct the radiomics based on CT data. mutation signature constructed whole genome sequencing data found be significantly associated prognosis ESCC. combining Rad-score constructed. An...
Abstract We purified from activated T lymphocytes a novel, highly conserved, 116-kDa, intracellular protein that occurred at high levels in the large, dividing cells of thymus, was up-regulated when resting or B hemopoietic progenitors were activated, and down-regulated monocytic leukemia, M1, induced to differentiate. Expression highest thymus spleen lowest tissues with low proportion such as kidney muscle, although expression brain. The localized cytosol phosphorylated, which is consistent...