A5101511153- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Acupuncture Treatment Research Studies
- Stress Responses and Cortisol
- Heart Rate Variability and Autonomic Control
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neural dynamics and brain function
- Traditional Chinese Medicine Studies
- Spaceflight effects on biology
- Synthesis and bioactivity of alkaloids
- Ion channel regulation and function
- Immune Cell Function and Interaction
- Memory and Neural Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Microfluidic and Capillary Electrophoresis Applications
- Gastrointestinal motility and disorders
- Innovative Microfluidic and Catalytic Techniques Innovation
- Radical Photochemical Reactions
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Health and Mental Health
- Vagus Nerve Stimulation Research
Shandong University of Traditional Chinese Medicine
2021-2025
Hubei University of Technology
2023-2025
Shandong University
2024-2025
Shanghai University of Traditional Chinese Medicine
2023
Guangzhou University of Chinese Medicine
2019-2021
Guangzhou University
2019
An efficient and eco-friendly approach for synthesizing difluoromethyl- aryldifluoromethyl-substituted polycyclic imidazoles was established via a visible-light-promoted radical cyclization reaction. This method employed the readily accessible inexpensive CF 2 HCO H or PhCF COOH, along with benzimidazoles bearing unactivated alkenes PhI(OAc) as substrates, proceeded without need of any base, metal catalyst, photocatalyst additive. In total, 24 examples were examined, all them successfully...
Early life stress is thought to be a risk factor for emotional disorders, particularly depression and anxiety. Although the excitation/inhibition (E/I) imbalance has been implicated in neuropsychiatric whether early affects E/I balance medial prefrontal cortex at various developmental stages unclear. In this study, rats exposed maternal separation (MS) that exhibited well-established paradigm were used evaluate adolescence (postnatal day P43-60) adulthood (P82-100) by behavior tests,...
Abstract Neuronal nitric oxide synthase (nNOS, gene name Nos1) orchestrates the synthesis of (NO) within neurons, pivotal for diverse neural processes encompassing synaptic transmission, plasticity, neuronal excitability, learning, memory, and neurogenesis. Despite its significance, precise regulation nNOS activity across distinct types remains incompletely understood. Erb-b2 receptor tyrosine kinase 4 (ErbB4), selectively expressed in GABAergic interneurons activated by ligand neuregulin 1...
The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood. This study sought to understand dietary habits, gut microbiota composition, etc. among individuals with SD investigate their association occurrence. Employing a cross-sectional approach, 178 SD, aged 18–32 years, were matched 114 healthy counterparts. status was evaluated using Zung Self-rating Depression Scale (SDS), Anxiety (SAS), Beck Inventory 2nd version...
Subthreshold depression (SD) is a prevalent condition among young adults, significantly increasing the risk of developing major depressive disorder (MDD). While symptoms MDD are well-documented, network structure and key SD, which forms complex, interdependent system, have not been fully elucidated. This study sought to identify central their interconnections within symptom in adults with SD. A total 834 Chinese SD completed 21-item Beck Depression Inventory 2nd version (BDI-II) were...
Antipsychotic-related constipation (APRC) is one of the most common side effects taking antipsychotic medication. APRC can seriously impact patient quality life and potentially fatal, though efficacy current treatments low for patients. In this study, we conducted a controlled, pilot randomized, sham-electroacupuncture (SEA) study to assess electroacupuncture (EA) in patients with APRC. We used 16S rRNA gene sequencing microbial profiles these analyze how EA affected their bacteria. Methods:...
Circulation dysfunction is a major contributing factor to thrombosis in patients with atrial fibrillation (AF) for which effective interventions are lacking. Growing evidence indicates that regulating the paraventricular nucleus (PVN), an autonomic control center, could offer novel strategy treating cardiovascular and circulatory diseases. Concurrently, electroacupuncture (EA) at Xinshu (BL15), form of peripheral nerve stimulation, has shown efficacy several conditions, although its specific...
A simple, straightforward and efficient method for the synthesis of a series 11-methyl-6 H -indolo[2,3- b ]quinolines bearing different substituents on indole quinoline rings is described.
Atrial fibrillation (AF) is the most common arrhythmia disease and associated with several cardiovascular cerebrovascular diseases. Consequently，the mortality rate of AF has increased in recent years. At present, treatment mainly based on medication radiofrequency ablation, but there are limitations such as adverse reactions high recurrence rates. Recently, autonomic nervous regulation become a new for AF. Our previous study showed that acupuncture at Neiguan (PC6) point can treat by...
Acupuncture has demonstrated positive efficacy in the treatment of brain disorders. However, significant challenges lie integrating acupuncture with modern technologies, promoting its clinical application treating disorders, elucidating mechanisms underlying acupuncture's preventive and therapeutic effects on accelerating pace translational development medicine. This paper briefly outlines current research status, challenges, potential future directions for aiming to provide essential...
Depression is a prevalent mental disorder characterized by unknown pathogenesis and challenging treatment. Recent meta-analyses reveal an association between cardiovascular risk factors elevated of depression. Despite this, the precise role vascular injury in depression development remains unclear. In this investigation, we assess system function three established animal models depression- chronic unpredictable mild stress (CUMS), social defeat (CSDS) maternal separation (MS)-utilizing...
<title>Abstract</title> Anxiety, as an early manifestation of Alzheimer’s disease (AD), plays a significant role in the initial stages cognitive decline and has negative impact on progression disease. However, specific pathological mechanisms underlying anxiety stage AD remain largely unknown. In this study, we investigated anxiety-like behaviors presenilin 1/2 conditional double knockout (PS cDKO) mice, which are commonly used to study AD. To characterize behaviors, conducted battery...