A5091610908- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Smoking Behavior and Cessation
- IL-33, ST2, and ILC Pathways
- School Health and Nursing Education
- Immunodeficiency and Autoimmune Disorders
- Synthesis of heterocyclic compounds
- Health Policy Implementation Science
- Synthesis and Reactions of Organic Compounds
- interferon and immune responses
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Histiocytic Disorders and Treatments
- Child Nutrition and Water Access
Guangxi Medical University
2003-2022
First Affiliated Hospital of GuangXi Medical University
2003-2022
Abstract Background The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis in human is still under investigation. aim this study was explore relationship between Th17-mediated and airway inflammation childhood asthma. Methods Twenty-eight children with exacerbated without using any glucocorticoids were divided into three groups: eosinophilic (EA, n = 12) group, (NA, 10) group paucigranulocytic...
Assisting smoking parents to quit and eliminating the secondhand smoke (SHS) exposure of their children is a global health priority. Engaging healthcare workers in developing countries address this priority has been challenge. This study intends explore issues around current practice related SHS assessment counseling identify barriers reduction Chinese pediatric setting.We conducted qualitative interviews (11 focus groups discussions (FGDs) with pediatricians, 6 FGDs nurses 11 in-depth...
Secondhand smoke (SHS) exposure of children due to parental tobacco use is a particularly prevalent health issue and associated with adverse outcomes. Following the US Clinical Practice guidelines, pediatricians in United States deliver 5A's (ask, advise, assess, assist, arrange) counseling smoking parents which has proven be effective. We examined Chinese pediatricians' adherence clinical practice guidelines for cessation (i.e. practices) parents, identified factors these practices. A...
Children's exposure to secondhand smoke (SHS) at home has numerous adverse health effects. This study evaluated the effects of a pediatric in-patient department-based pilot smoking cessation intervention for household members reduce children's SHS and encourage cessation. A pre-post test design was designed assess effectiveness telephone counseling on hospitalized children in departments. Data were collected with standardized Chinese language questionnaire. At three-month follow-up survey,...
Evidence-based tobacco control strategies delivered through pediatric settings could encourage parental smoking cessation and reduce children's exposure to second hand smoke (SHS) in the United States. The extent which these be routinely implemented setting of a developing country is not known. We tested feasibility efficacy implementing an evidence-based intervention, Clinical Effort Against Secondhand Smoke Exposure (CEASE), Chinese hospital address children home car smoking.We conducted...
1岁9月龄男性患儿存在胎儿期宫内发育迟缓、小头畸形、小脑发育不良和体格发育迟缓，同时表现为早发的联合免疫缺陷、小肠结肠炎及骨髓衰竭，进而合并严重感染，出现巨细胞病毒感染所致坏死性视网膜综合征及大肠埃希菌败血症。经基因检测分析发现DKC1基因半合子错义变异c.146C>T（p.Thr49Met），该变异遗传自母亲，且该变异为Hoyeraal-Hreidarsson综合征已知的致病性变异。.
Abstract Background: The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis in human is still under investigation. aim this study was explore relationship between Th17-mediated and airway inflammation childhood asthma. Methods: Twenty-eight children with exacerbated without using any glucocorticoids were divided into three groups: eosinophilic (EA, n=12) group, (NA, n=10) group...
Objective To study the effect of inhibiting phosphorylation signal transducer and activator transcription-3 (STAT3) on Th2 cell-mediated airway inflammation remodeling, to explore role STAT3 in pathophysiology bronchial asthma. Methods Forty Balb/c mice were randomly divided into control group(n=10), asthma AG490 by intraperitoneal group (n=10), inhalation (n=10). The sensitized with ovalbumin establish asthmatic model.The histological changes evaluated means HE staining, while total...
Abstract Background The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether Th17-mediated immunity contributes to the pathogenesis in human is still under investigation. aim this study was explore relationship between and airway inflammation childhood asthma. Methods Twenty-eight children with exacerbated without using any glucocorticoids were divided into three groups: eosinophilic (EA) group, (NA) group paucigranulocytic (PGA) according induced sputum...
1例主诉为“反复咳嗽伴痰鸣2年余”的2岁10月龄患儿就诊。患儿有反复呼吸道感染、活动不耐受，查体见杵状指，鼻窦CT示鼻窦炎。患儿婴儿期有可疑脂肪泻，血脂示甘油三酯、低密度脂蛋白胆固醇、载脂蛋白B明显降低。结合全基因组外显子测序检测结果，最终诊断为原发性纤毛运动障碍合并无β脂蛋白血症。.