A5045572371- Gut microbiota and health
- Ruminant Nutrition and Digestive Physiology
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Reproductive Physiology in Livestock
- Infant Nutrition and Health
- Biofuel production and bioconversion
- Plant and fungal interactions
- Anaerobic Digestion and Biogas Production
- Meat and Animal Product Quality
- Genetic and phenotypic traits in livestock
- Microbial Metabolites in Food Biotechnology
- Biochemical Analysis and Sensing Techniques
- Gout, Hyperuricemia, Uric Acid
- Adipose Tissue and Metabolism
- Genomics and Phylogenetic Studies
- Agriculture Sustainability and Environmental Impact
- Food composition and properties
- Digestive system and related health
- Animal Behavior and Welfare Studies
- Clinical Nutrition and Gastroenterology
- Pharmacological Effects of Natural Compounds
- Phytoestrogen effects and research
Nanjing Agricultural University
2016-2025
Fudan University
2025
Département Santé Animale
2017-2025
Tibet Academy of Agricultural and Animal Husbandry Sciences
2023
Guangzhou Medical University
2010-2023
Kerala Veterinary and Animal Sciences University
2019-2021
Cambridge University Press
2021
New York University Press
2021
Brigham and Women's Hospital
2020
Federation of American Societies for Experimental Biology
2020
Abstract The bacterial community composition and function in the gastrointestinal tracts (GITs) of dairy cattle is very important, since it can influence milk production host health. However, our understanding communities GITs still limited. This study analysed ten distinct GIT sites (the digesta mucosa rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, cecum, colon rectum) six cattle. observed 542 genera belonging to 23 phyla distributed throughout GITs, with Firmicutes,...
Summary Currently, knowledge about the impact of high‐grain ( HG ) feeding on rumen microbiota and metabolome is limited. In this study, a combination 454 pyrosequencing strategy mass spectrometry‐based metabolomics technique was applied to investigate effects increased dietary grain (0%, 25% 50% maize grain) changes in whole ruminal their metabolites using goat as ruminant model. We observed significant influence shaping bacterial community structure, diversity composition, with an overall...
A reciprocal cross-fostering model with an obese typical Chinese piglet breed and a lean Western was used to identify genetic maternal effects on the acquisition development gut bacteria from birth until after weaning. Pyrosequencing of 16S rRNA genes results revealed age- diet-dependent bacterial succession process in piglets. During first 3 days birth, community relatively simple dominated by Firmicutes 79% 65% relative abundance for Meishan Yorkshire piglets, respectively. suckling period...
Abstract Background Gastrointestinal tract (GIT) microbiomes in ruminants play major roles host health and thus animal production. However, we lack an integrated understanding of microbial community structure function as prior studies are predominantly biased towards the rumen. In this study, used shotgun metagenomics to profile microbiota 370 samples that represent 10 GIT regions seven ruminant species. Results Our analyses reconstructed a reference catalog with > 154 million...
The development of the rumen is an important physiological challenge for young ruminants. Previous studies have shown that starter feeding can effectively facilitate growth and in However, mechanism through which stimulates not clear. Here, we performed integrated analysis ruminal microbiota a host transcriptomic profile lamb model with intervention feed to understand microbiome-host crosstalk stimulating epithelium. Decreased pH increased acetate butyrate concentrations rumen, followed by...
Dairy cattle (Bos taurus), especially Holstein cows, which are the highest-producing dairy animals and widely bred to provide milk products humans, rely critically on their associated gastrointestinal tract (GIT) microbiota digest plant feed. However, region-specific taxonomic composition function of GIT microbiome in mechanistic basis for diet-induced effects remain be elucidated. RESULTS: We collected 120 digesta samples from 10 regions 12 cows fed forage- grain-based diets characterized...
To determine the in-vitro effect and mode of action tea saponin on rumen microbial community methane production.Saponin extracted from seeds was added to (1) an fermentation inoculated with fluid (2) a pure culture Methanobrevibacter ruminantium. Methane production expression methyl coenzyme-M reductase subunit A (mcrA) were monitored in both cultures. Abundance methanogens, protozoa, fungi cellulolytic bacteria quantified using real-time PCR, bacterial diversity observed denaturing gradient...
Alterations in rumen epithelial tight junctions (TJs) at the tissue and molecular levels during high-grain (HG) diet feeding are unknown. Here, 10 male goats were randomly assigned to either a hay (0% grain; n = 5) or HG group (65% characterize changes ruminal structure TJ protein expression localization using scanning transmission electron microscopy, quantitative real-time PCR, Western blot analysis, immunofluorescence. After 7 wk of feeding, free LPS increased significantly ( P <...
Abstract Long-term consumption of red meat has been considered a potential risk to gut health, but this is based on clinic investigations, excessive intake fat, heme and some injurious compounds formed during cooking or additions processed products. Whether protein affects bacteria the health host remains unclear. In work, we compared composition in caecum, by sequencing V4-V5 region 16S ribosomal RNA gene, obtained from rats fed with proteins (beef pork), white (chicken fish) other sources...
Sub-acute ruminal acidosis (SARA) is a well-recognized digestive disorder found in particular well-managed dairy herds. SARA can result increased flow of fermentable substrates to the hindgut, which increase production volatile fatty acids, alter structure microbial community, and have negative effect on animal health productivity. However, little known about changes community its relationship with acids during SARA. Four cannulated primiparous (60 90 day milk) Holstein cows were assigned...
The objective of this research was to compare the composition bacterial microbiota associated with ruminal content (RC), epithelium (RE) and faeces Holstein dairy cows. RC, RE faecal samples were collected from six cows when animals slaughtered. Community compositions 16S rRNA genes determined using a MiSeq sequencing platform bacterial-targeting universal primers 338F 806R. UniFrac analysis revealed that communities clearly separated each other. Statistically significant dissimilarities...
A high-protein diet (HPD) can produce hazardous compounds and reduce butyrate-producing bacteria in feces, which may be detrimental to gut health. However, information on whether HPD affects intestinal function is limited.The aim of this study was determine the impact an microbiota, microbial metabolites, epithelial transcriptome colons rats.Adult male Wistar rats were fed either a normal-protein (20% protein, 56% carbohydrate) or (45% 30% for 6 wk (n = 10 per group, individually fed). After...
This study was conducted to investigate the supplemental effects of purified bioflavonoids (genistein and hesperidin), as potential alternatives plant/herbs or synthetic antioxidants, individually in combination for fatty acid profile, lipid metabolites, antioxidant status broilers. Three hundred sixty 1-d-old broilers were divided into 6 treatment groups: control (basal diet), G5 (5 mg genistein per kg feed), H20 (20 hesperidin whereas other 3 groups supplemented with a mixture (20% + 80%...
High-grain (HG) feeding used in intensive goat production can affect the physiology of rumen wall, but changes induced epimural bacterial community and host Toll-like receptors (TLRs) are not well understood. In this study, 10 male goats were randomly allocated to two groups fed either a hay diet (0% grain; n = 5) or an HG (65% 5). The ruminal epithelial expression TLRs during long-term (7 weeks) determined using pyrosequencing quantitative real-time polymerase chain reaction. Principal...