A5016641608- Virus-based gene therapy research
- Virology and Viral Diseases
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- COVID-19 Pandemic Impacts
- Nutritional Studies and Diet
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
- COVID-19 Impact on Reproduction
- interferon and immune responses
- Pharmaceutical and Antibiotic Environmental Impacts
- Pesticide and Herbicide Environmental Studies
- Nutrition, Health and Food Behavior
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- CRISPR and Genetic Engineering
Huazhong University of Science and Technology
2021-2025
Central Hospital of Wuhan
2021-2025
Hebei Agricultural University
2015-2024
Peking University
2020-2023
Tsinghua University
2022
Vanke (China)
2022
Tropical Bioscience and Biotechnology Research Institute
2020
Chinese Academy of Tropical Agricultural Sciences
2020
Beijing University of Agriculture
2018-2019
Third Hospital of Changsha
2019
COVID-19, a Public Health Emergency of International Concern, has imposed enormous challenges on the health system, economy, and food supply substantially modified people’s lifestyles. This study aimed to (1) explore dietary diversity during lockdown time in China (2) examine factors associated with including socio-economic characteristics, sources for purchases, specific behaviors responding COVID-19 isolation. A cross-sectional questionnaire-based survey was conducted online March 2020....
Reproductive health is a significant public issue during pandemics; however, the impacts of novel 2019 coronavirus disease (COVID-19) on noninfected pregnant women are still unknown. This study intends (1) to examine whether emotional eating (EE) occurred pandemic triggered by concerns and (2) explore associations among EE, dietary changes, gestational weight gain (GWG). Based an online survey, 640 new mothers who experienced lockdown in their third trimester were recruited from seven...
Coronavirus disease 2019 (COVID-19) has imposed enormous challenges on people’s lifestyles. People in China have gradually returned to normal life; however, the protracted pandemic, people may still follow certain dietary behaviors cope with COVID-19. This study was second stage of a longitudinal nutritional survey conducted post-lockdown that aimed at exploring and their effects diversity. In line first survey, current used COVID-19 ways purchasing food were determined. addition, changes...
ABSTRACT Influenza viruses (IVs) threaten global human health due to the high morbidity, infection, and mortality rates. Currently, influenza drugs recommended by Food Drug Administration are oseltamivir, zanamivir, peramivir, baloxavir marboxil. These antivirals currently effective for major subtypes of IVs as compounds target conserved domains in neuraminidase or polymerase acidic (PA) protein. However, this trend may gradually change selection antiviral natural evolution IVs. Therefore,...
Tanshinone IIA (Tan IIA) possesses potent anti-atherogenic function, however, the underlying pharmacological mechanism remains incompletely understood.Previous studies suggest that oxidized LDL (oxLDL)-induced NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) inflammasome activation in macrophages plays a vital role atherogenesis.Whether effect of Tan relies on inhibition has not been investigated before.In this study, we found treatment high-fat diet fed ApoE-/-mice...
Arteriovenous fistula stenosis is a common complication in hemodialysis patients, yet effective predictive tools are lacking. This study aims to develop an interpretable machine learning model for risk prediction. Clinical data from 974 patients (55 features) undergoing arteriovenous dialysis at The Central Hospital of Wuhan (2017-2024) were analyzed retrospectively. dataset was split into training (70%) and test (30%) sets. Seven models-Random Forest, XGBoost, Support Vector Machine,...
We examined how Raoultella ornithinolytica-ZK4 degraded pyrethroid pesticides within soil sediment from an abandoned pesticide plant. Lambda-cypermethrin and deltamethrin are two insecticides with high insecticidal activity a wide range of applications. However, their increased use has raised concerns regarding toxicity accumulation. isolated strain ZK4 (Raoultella ornithinolytica-ZK4) taken channel that surrounded used enzyme localization to study degrading bacteria ZK4. The underwent...
Abstract Background Improving and maintaining the health of mothers newborns is indisputably a global priority, especially during pandemic. This study intends to examine factors associated with cesarean section (CS) lockdown time. Methods A total 678 women who just gave birth within 7 days were enrolled from maternal children hospitals in nine cities China April May 2020. The delivery modes potential influencing investigated. subgroup analysis sensitivity used association CS risk among...
Objective To generate recombinant Bacillus subtilis (B. subtilis) engineered for expression of porcine β-defensin-2 (pBD-2) and cecropin P1 (CP1) fusion antimicrobial peptide investigate their anti-bacterial activity in vitro growth-promoting disease resisting vivo. Methods The pBD-2 CP1 fused gene was synthesized using the main codons B. inserted into plasmid pMK4 vector to construct vector. peptide-expressing constructed by transformation with expressed detected Western blot. recovered...
Cutaneous melanoma is one of the most common malignant skin tumors, with a continuously increasing incidence. Cyclin-dependent kinase (CDK) 2 key regulator G1-S transition and modulation G2 progression; however, its role in cancer matter debate. In present study, lentivirus expressing single-guide RNA (sgRNA) was constructed to knock out CDK2 using CRISP/Cas9 technology, order confirm A375 human cells. The results demonstrated that knockout induced G0/G1 phase arrest early apoptosis by...
Chicken infectious bursal disease (IBD) is still incompletely controlled worldwide. Although IBD virus (IBDV) VP2 DNA vaccine was considered a safe for prevention, the immunogenicity by itself remains poor, resulting in failure of effectively protecting chickens from infection. We and others demonstrated that chicken IL-2 (chIL-2) chIL-7 have capacity to enhance vaccine. However, whether chIL-2 can mutually thereby augment latter’s protection efficacy unknown. By using chIL-2/chIL-7...
This study aimed to explore food and nutrition related concerns during the post-lockdown period their impacts on shopping, preparation, eating behaviors.A cross-sectional was conducted through online questionnaire. We collected data concerns, socio-demographic characteristics, changes in dietary total of 2267 responses were received from people living 31 provinces across mainland China 1994 participants included final analysis.Linear multinomial logistic regression analyses performed...
Mammalian interleukin-7 (IL-7) is able to stimulate lymphocyte proliferation and maturation, reverse immunosuppression. However, whether poultry IL-7 has similar functions remains unclear. Chicken infectious bursal disease virus (IBDV) causes serious immunosuppression in chicken due virus-induced immune disorder. Whether (chIL-7) the ability restore immunity during IBDV-induced not clear. To test this, we amplified chIL-7 gene by RT-PCR, prepared recombinant using HEK293T cells treated with...
We present an efficient and easy synthesis method for incorporating organocatalytic moieties into Zr-metal organic frameworks (Zr-MOFs). The catalytic activity selectivity of the new chiral catalysts were improved by adjusting aperture MOF cavities. hole size Zr-MOF was modulated adding acid replacing bridge ligands during synthesis. difunctional units amino acid-thiourea are anchored onto a mild from isothiocyanate intermediate which could effectively avoid racemization in process. By means...
Our previous work showed that a plasmid-based chicken interleukin-7 (chIL-7) gene expression vector possessed potent adjuvant activity for VP2 DNA vaccine against infectious bursal disease virus (IBDV). Whether recombinant chIL-7 prepared in procaryotic system has the inactivated IBDV remains unknown. Here, we using an E. coli and analyzed its vaccine. The results show was successfully pET20b vector, which biological to stimulate mouse B lymphocyte proliferation. Co-administration of with...