A5102844880- Inflammasome and immune disorders
- Cardiovascular Health and Disease Prevention
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Thermoregulation and physiological responses
- Blood Pressure and Hypertension Studies
- Exercise and Physiological Responses
- COVID-19 Impact on Reproduction
- Hemoglobinopathies and Related Disorders
- Macrophage Migration Inhibitory Factor
- Machine Learning in Bioinformatics
- Cholesterol and Lipid Metabolism
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Nuclear Receptors and Signaling
- Calpain Protease Function and Regulation
- Cardiovascular and exercise physiology
- Phytase and its Applications
- Parvovirus B19 Infection Studies
- Atherosclerosis and Cardiovascular Diseases
- Eosinophilic Esophagitis
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
People's Liberation Army 401 Hospital
2024
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
First Affiliated Hospital of Fujian Medical University
2020-2021
Fujian Medical University
2020-2021
South China University of Technology
2021
82th Hospital of Pla
2021
PLA 306 Hospital
2016
Tanshinone IIA (Tan IIA) possesses potent anti-atherogenic function, however, the underlying pharmacological mechanism remains incompletely understood.Previous studies suggest that oxidized LDL (oxLDL)-induced NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) inflammasome activation in macrophages plays a vital role atherogenesis.Whether effect of Tan relies on inhibition has not been investigated before.In this study, we found treatment high-fat diet fed ApoE-/-mice...
To investigate whether exercise preconditioning (EP) improves the rat cardiac dysfunction induced by exhaustive (EE) through regulating NOD-like receptor protein 3 (NLRP3) inflammatory pathways and to confirm which intensity of EP is better.Ninety healthy male Sprague Dawley rats were randomly divided into five groups: a control group (CON), (EE), low-, middle-, high-intensity precondition (LEP + EE, MEP HEP EE group). We established experimental model referring Bedford's motion load...
Listeria monocytogenes (LM), a foodborne pathogen, can cause pregnancy failure in animals, especially ruminants. Recent studies have shown that LM activates inflammasomes to induce IL-1β release macrophages, however, whether the inflammasome activation regulates LM-induced remains largely unknown. Here we used mouse model investigate molecular mechanism by which inflammsome contributes LM-associated We showed wild-type, but not Listeriolysin O-deficient (Δhly) LM, significantly reduced...
To investigate the persistence time and effectiveness of exercise preconditioning (EP) on myocardial protection in exhausted rats from enzymes, electrocardiogram (ECG), cardiac function, mitochondrial respiratory function after cessation training. One hundred twelve healthy male Sprague–Dawley were randomly divided into seven groups ( n = 16): control group (CON), exhaustive (EE) group, EP EE (EP + EE); furthermore, was 1D, 3D, 9D, 18D (1D, 18D) performed treadmill at a speed 30 m/min 1 st ,...
OBJECTIVE To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-κB (NF-κB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation Nod-like receptor protein 3 (NLRP3) inflammasome microglials and its effects on neurons. METHODS Murine microglial cell line Bv-2 was infected with a lentivirus carrying MIF shRNA for knockdown then treated MPP+. The total levels NLRP3, caspase-1, p65...
Hypoxia has a major regulatory impact on the electrical activity transmission in myocardium, and it is involved development of tachyarrhythmia disease. Anchor protein G (ankyrin-G, ANK-G) associated with voltage-gated Na
Background: CathepsinB (CTSB) is a lysosomal cysteine protease which has been implicated in variety of physiological and pathological processes. However, the sequence structure characteristics sheep CTSB gene are still unclear, severely restricts further study about genetic variation, molecular evolution. Methods: Therefore coding (CDS) from ovary was cloned by reverse transcription PCR (RT-PCR) amplification regular sequencing technology. The nucleotide amino acid were analyzed through...
Abstract Background: Osteonecrosis of femoral head (ONFH) is a common ischemic disease that induces necrosis. The role exosomes and miRNA in ONFH has been elucidated, however, whether miRNA-modified improve the therapy not clear.Methods: We screened ONFH-related miRNAs by RNA sequencing plasma patients healthy donors. key was overexpressed bone marrow mesenchymal stem cells (BMSC) exosomes. regulatory functions BMSC vascular endothelial were illustrated through angiogenesis assay scratch...
Abstract Background To investigate arterial endothelial function and related factors in elderly patients with both essential hypertension abdominal obesity. Methods A total of 658 (≥60 years old) 64 subjects without were recruited. Hypertension obesity defined based on blood pressure (≥140/90 mm Hg) waist circumference (male ≥90, female ≥85 cm), respectively. Endothelium-dependent dilatation (EDD) anterior tibial artery induced by reactive hyperemia was examined high-resolution vascular...
Abstract Background To investigate the relationship between abdominal obesity and endothelial function of tibial artery in elderly essential hypertensives different sex. Methods A total 658 patients (≥60 years old) with hypertension 64 subjects without clinical evidence were recruited from department geriatrics August 2000 to May 2016. The dilatation anterior induced by reactive hyperemia was examined high-resolution vascular ultrasound defined as endothelium-dependent (EDD). All...