A5101943223- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Antioxidant Activity and Oxidative Stress
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Ferroptosis and cancer prognosis
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Protease and Inhibitor Mechanisms
- Ginseng Biological Effects and Applications
- PI3K/AKT/mTOR signaling in cancer
- Traditional Chinese Medicine Analysis
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Jiangxi Provincial People's Hospital
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Peking University
2016-2024
Gansu Provincial Maternal and Child Health Hospital
2021-2024
Gansu Provincial Center for Disease Control and Prevention
2023-2024
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2024
Hebei General Hospital
2024
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and it carries a poor prognosis due to high rate recurrence or metastasis after surgery. Bmi-1 plays significant role in growth many solid tumours. However, exact mechanisms underlying Bmi-1-mediated cell invasion metastasis, especially HCC, are not yet known. In present study, we sought evaluate expression HCC samples its relationship with clinicopathological characteristics prognostic value, also investigated...
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Abstract Hypersecretion of mucus is an important component airway remodeling and contributes to the plugs airflow obstruction associated with severe asthma phenotypes. Lyn has been shown down-regulate allergen-induced inflammation. However, role in mucin gene expression remains unresolved. In this study, we first demonstrate that overexpression decreased hypersecretion levels muc5ac transcript mice exposed ovalbumin (OVA). also infiltration inflammatory cells IL-13 IL-4 OVA-challenged...
Abstract Constant exposure to allergen triggers destructive type 2 cell-mediated inflammation. The effect of specific immunotherapy (SIT) in maintaining airway epithelial barrier function asthma remains unknown. In the current study, we showed that SIT maintained homeostasis mice exposed dermatophagoides farinae ( Der f ), which induced increased expression IL-25, endoplasmic reticulum (ER) stress and apoptosis. Meanwhile, treatment ameliorated inflammatory infiltration hyper-responsiveness...
Dose-response and nonlinear relationships of cigarette exposure with sleep disturbances depression are warranted, the potential mechanism sex hormones in such associations remains unclear.
Background Fluid intake in the elderly may influence urination behaviors and further their health status. This study investigated of fluid intake, relationships among China. Methods Stratified random sampling was used to recruit participants who met inclusion criteria from five cities Participants’ total (TFI) level using a validated 7-day 24 h questionnaire. Their real time were also recorded behavior record. Results A 524 completed study, including 233 males 291 females. The average age...
Hyperlipidemia is a strong risk factor for numerous diseases. Resveratrol (Res) non-flavonoid polyphenol organic compound with multiple biological functions. However, the specific molecular mechanism and its role in hepatic lipid metabolism remain unclear. Therefore, aim of present study was to elucidate underlying how Res improves by decreasing microRNA-33 (miR-33) levels. First, blood miR-33 expression participants hyperlipidemia detected reverse transcription-quantitative PCR, results...
Porcine parvovirus (PPV) is an important pathogen causing reproductive failure in pigs. PPV-induced cell apoptosis has been recently identified as being involved placental tissue damages resulting failure. However, the molecular mechanism was not fully elucidated. Here we demonstrate that PPV nonstructural protein 1 (NS1) can induce host and death, thereby indicating NS1 may play a crucial role We have found NS1-induced significantly inhibited by caspase 9 inhibitor, but 8 transfection of...
One of the major risk factors for asthma development is exposure to environmental allergens. House dust mites (HDM) can induce DNA damage, resulting in asthma. Resveratrol (RES) produced by several plants, has anti‑apoptotic properties and may affect a variety biological processes. The aim present study was investigate protective role RES against apoptosis bronchial epithelial cells. C57BL/6J mice treated with HDM exhibited high levels cell apoptosis, while significantly reversed this...
Glioblastoma is the most malignancy tumor generated from central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association patients' poor outcome in various tumor. Recently, several studies revealed glioblastoma progression but mechanism remained unknown. Autophagy a programmed cells death and acts critical role progression. In this study, pentraxin recognized as prognostic prediction biomarker of can promote through negative modulating...
Lycopene has produced robust clinical effects and shows a promising chemopreventive in the oral cancer precancerous lesions. However, much is still unknown about its mechanisms of carotenoid protecting against squamous cell carcinoma (OSCC). Insulin-like growth factor 1 (IGF1) pathway serves as key regulatory signal tumor microenvironment, which may be associated with angiogenesis, tumorigenicity, proliferation. The current study was focused on elucidating potential played for lycopene to...
Obesity is tightly associated with the disturbance of white adipose tissue storing excess energy. Thermogenic adipocytes (brown and beige) exert a critical role oxidizing nutrients at high rates through non‐shivering thermogenesis. The recruitment brown characteristics in adipocytes, termed browning, has been considered as promising strategy for treating obesity metabolic complications. Recently, long noncoding RNAs play crucial regulating development participating disease pathogenesis, yet...
Inducible Nitric Oxide Synthase (iNOS) has been involved in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study was performed identify natural inhibitors from traditional Chinese herbs through combi
Mucus secretion accumulation in the airways may act as a contributing factor for development of airflow limitation severe fetal asthma patients. Accumulated evidences showed that transforming growth beta (TGF-β) plays regulatory role airway remodeling including mucus hyper-secretion asthma. However, detailed molecular mechanisms TGF-β3 induced MUC5AC hyper-expression epithelium remains unclear. Here, we demonstrated pivotal roles autophagy regulation hyper-production by epithelium. Our...
Chicken infectious bursal disease (IBD) is still incompletely controlled worldwide. Although IBD virus (IBDV) VP2 DNA vaccine was considered a safe for prevention, the immunogenicity by itself remains poor, resulting in failure of effectively protecting chickens from infection. We and others demonstrated that chicken IL-2 (chIL-2) chIL-7 have capacity to enhance vaccine. However, whether chIL-2 can mutually thereby augment latter’s protection efficacy unknown. By using chIL-2/chIL-7...