A5005228665- Ocular Diseases and Behçet’s Syndrome
- Ferroptosis and cancer prognosis
- Retinal Diseases and Treatments
- Natural Compounds in Disease Treatment
- Retinal and Optic Conditions
- Iron Metabolism and Disorders
- Clusterin in disease pathology
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Chongqing Medical University
2023-2024
National Clinical Research Center for Digestive Diseases
2023
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Among aging adults, age-related macular degeneration (AMD), is a prevalent cause of blindness. Nevertheless, its progression may be halted by antioxidation in retinal pigment epithelium (RPE). The primary effective constituent Tripterygium wilfordii Hook. F., triptolide (TP), has demonstrated anti-inflammatory, antiproliferative, and antioxidant properties. mechanics the protective effect against oxidative damage epithelial (RPE) were assessed this study.
In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm size, that are within range cellular molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs overcome obstacles, target drug delivery, prolong release, reduce toxicity, be used gene therapy. After brief introduction classification NPs, we will focus potential applications...
Abstract Age-related macular degeneration (AMD) is one of the three major blindness diseases. Retinal pigment epithelium (RPE) dysfunction due to smoking an essential environmental factor in pathogenesis AMD. Ferroptosis a novel type iron-dependent programmed cell death (PCD). However, relationship between cigarette smoke extract (CSE)-induced RPE damage and ferroptosis remains unclear. In this study, we observed that CSE induced cellular human retinal epithelial line (ARPE-19), resulting...