A5081026391- Ocular Diseases and Behçet’s Syndrome
- Inflammasome and immune disorders
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytomegalovirus and herpesvirus research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2023
Chongqing Medical University
2022-2023
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Our previous study demonstrated that intrahepatic Th17 cells exacerbated the progression of chronic hepatitis B virus (HBV) infection. Meanwhile, we found a small group IFN-γ and IL-17 double-positive (IFN-γ+IL-17+ cells) in liver tissues. This aimed to investigate clinical significance properties IFN-γ+IL-17+ injury associated with HBV infection.The frequencies CD4+ Th cells, Tregs, T expressing specific chemokine receptors blood tissues were detected using flow cytometry. The chemotaxis C...