A5102781871- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Higher Education and Teaching Methods
- Online and Blended Learning
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ferroptosis and cancer prognosis
- Education and Work Dynamics
- Systemic Lupus Erythematosus Research
- Renin-Angiotensin System Studies
- Inflammasome and immune disorders
- Second Language Learning and Teaching
- Cholesterol and Lipid Metabolism
- EFL/ESL Teaching and Learning
- Retinoids in leukemia and cellular processes
- Extracellular vesicles in disease
- Ocular Oncology and Treatments
- Problem and Project Based Learning
- Ophthalmology and Visual Health Research
- Drug-Induced Ocular Toxicity
- Neurological Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
Chongqing Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Yunnan University of Traditional Chinese Medicine
2025
Yunnan University
2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
National Clinical Research Center for Digestive Diseases
2023
National University of Defense Technology
2015
Zhejiang University of Science and Technology
2008
University of South China
2007
Uveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from Hedyotis diffusa, known for its notable anti-inflammatory antioxidant characteristics. The present study explored potential effects fundamental processes of ASPA by injecting it or placebo into vitreous rats endotoxin-induced uveitis (EIU). severity was assessed using clinical scores obtained through slit lamp examination....
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Oxidative stress-prompted degeneration of the retinal pigment epithelium (RPE) notably contributes to onset age-related macular (AMD). However, pathways leading RPE deterioration and possible preventative strategies are not yet completely comprehended. Ferroptosis was assayed through evaluation lipid peroxidation (C11-BODIPY MDA), reactive oxygen species (ROS), transmission electron microscopy (TEM), iron content measurement, q-PCR, western blotting, immunofluorescence. To assess structure...
Early detection and intervention of precancerous lesions are crucial in reducing cancer morbidity mortality. Comprehensive analysis genomic, transcriptomic, proteomic epigenomic alterations can provide insights into the early stages carcinogenesis. However, lacke an integrated, well-curated data resource molecular signatures limits our understanding processes. Here, we introduce a comprehensive PreCancerous Molecular Resource (PCMR), which compiles 25,828 profiles samples paired with normal...
Purpose.: The proinflammatory cytokine interleukin-17 (IL-17) has recently been shown to promote angiogenesis. In addition, a receptor for IL-17, IL-17 C (IL-17RC), is enriched in patients with wet, age-related macular degeneration (AMD), disease characterized by the formation of choroidal neovascularization. However, role endothelial cells (CECs) angiogenesis not defined. This study was conducted determine effect on proliferation, migration, and tube human CECs.
This study compares the effectiveness of Conbercept and Aflibercept in treating neovascular age-related macular degeneration (nAMD). Conducted at First Affiliated Hospital Chongqing Medical University's Ophthalmology Department (May 2020-May 2023), this prospective enrolled 159 nAMD patients. Participants were randomly divided into two groups: one receiving 0.5 mg other 2 intravitreal injections. Over 12 months, study, employing a Treat-and-Extend (T&E) regimen, assessed Best-Corrected...
Purpose: To study whether aqueous humor (AH) and plasma adiponectin (APN) levels were altered in proliferative diabetic retinopathy (PDR).Materials Methods: After excluding subjects with hypertension, hyperlipidaemia, nephropathy, coronary heart disease, renal failure, 20 consecutive type 2 diabetes mellitus (DM) PDR patients age-matched non-diabetic senile cataract (non-DM) controls enrolled this study. AH APN concentrations determined by enzyme-linked immunosorbent assay (ELISA). The...
Among aging adults, age-related macular degeneration (AMD), is a prevalent cause of blindness. Nevertheless, its progression may be halted by antioxidation in retinal pigment epithelium (RPE). The primary effective constituent Tripterygium wilfordii Hook. F., triptolide (TP), has demonstrated anti-inflammatory, antiproliferative, and antioxidant properties. mechanics the protective effect against oxidative damage epithelial (RPE) were assessed this study.
Purpose To describe a case of acute macular neuroretinopathy (AMN) associated with COVID-19 infection and related literature review. Methods A from the First Affiliated Hospital Chongqing Medical University was reported that could be linked to or SARS-CoV-2 infection. We performed comprehensive search on PubMed, retrieving articles containing information AMN after The key words used were ‘COVID-19’, ‘SARS-CoV-2’, ‘ophthalmic manifestations’, ‘acute neuroretinopathy’, ‘paracentral scotomas’....
Abstract The inositol trisphosphate (InsP3) receptor is an essential regulator of intracellular calcium in many cells including chemoattractant- and cytokine-stimulated neutrophils differentiated promyelocytic leukemic (HL-60) cells. We examined the expression function InsP3 transcriptional regulation gene HL-60 treated for 1-5 days with 1 microM retinoic acid. Radioligand binding studies using membranes from control acid-treated showed that Bmax increased progressively 0.24 to 0.69 pmol/mg...
Interleukin-17 (IL-17) is a major pro-inflammatory cytokine involved in choroidal endothelial cell (CEC) angiogenesis. Proteins expressed by the retinal pigment epithelium (RPE) may contribute to CEC The ability of IL‑17 promote proliferation, migration and capillary‑like structure formation CECs was investigated stimulating RPE vitro. were cultured conditioned medium (CM) with (IL‑17‑CM) or without obtained from supernatant an ARPE‑19 line. pro‑angiogenic role IL‑17‑CM on water‑soluble...
To investigate serum levels of soluble CD146 (sCD146) and vascular endothelial growth factor receptor 2 (VEGFR2) in patients with age-related macular degeneration (AMD).Eighty-eight exudative AMD 45 sex- age-matched healthy controls were enrolled this study conducted China. Serum samples was obtained from the controls. sCD146 VEGFR2 protein measured using an enzyme-linked immunosorbent assay.We found that significantly higher group than (t=3.859, P<0.001 t=3.829, P<0.001, respectively)....
Neutrophils participate in the advancement of human innate immune system and respond to perceived endogenous exogenous threats. As a response mechanism, neutrophil extracellular traps (NETs) form near pathogens surrounding tissues during an response. Drusen is important marker Age-Related Macular Degeneration (AMD) plays role course AMD. Aβ1-40 main component drusen. However, relationship between NETs AMD or unclear. Here, we found elevated levels serum patients mouse models. We also...
<p>This study, carried out at a major technological university in China and based on convenience sample of 116 students, is designed to identify which aspects their classroom environments had the greatest effect students. Students completed 26-item questionnaire elicited general as well specific views EFL environments. The students were divided into English majors (n=64) non-English (n=52). results showed that, among items rated less satisfactory, eight similar for both groups, but...
Visual quality after multifocal intraocular lens (mIOL) implantation has received increased attention. Postoperative residual ametropia, posterior capsule opacification, dry eye, IOL decentration, pupil size, and other factors can affect patient visual acuity. In addition, dissatisfaction mIOL a relationship with the near add power of mIOLs, which is correlated vision habits different patients. Indeed, actual spectacle plane mIOLs incompletely consistent given by manufacturers. Ocular...
In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm size, that are within range cellular molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs overcome obstacles, target drug delivery, prolong release, reduce toxicity, be used gene therapy. After brief introduction classification NPs, we will focus potential applications...
This trial aimed to compare the efficacy and safety between biosimilar QL1207 reference aflibercept for treatment of neovascular age-related macular degeneration (nAMD). randomized, double-blind, phase 3 was conducted at 35 centers in China. Patients aged ≥ 50 years old with untreated subfoveal choroidal neovascularization secondary nAMD best-corrected visual acuity (BCVA) letter score 73-34 were eligible. randomly assigned receive intravitreous injections or 2 mg (0.05 ml) study eye every 4...