A5069356304- Retinal Diseases and Treatments
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Calpain Protease Function and Regulation
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
- RNA modifications and cancer
- Cardiovascular Health and Disease Prevention
- Sirtuins and Resveratrol in Medicine
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Curcumin's Biomedical Applications
- Mesenchymal stem cell research
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- RNA regulation and disease
- Heart rate and cardiovascular health
- Topic Modeling
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Corneal Surgery and Treatments
Ningbo University
2024-2025
Wenzhou Medical University
2015-2025
Lishui Central Hospital
2015-2024
First Affiliated Hospital of Jiangxi Medical College
2023-2024
Jiangxi Provincial People's Hospital
2018-2023
Nanchang University
2017-2020
Lishui University
2015-2018
Zhejiang University
2015-2018
First Affiliated Hospital of Nanchang University
2017
May Institute
2016
Resveratrol (RSV) is used as a protective therapy against diabetic retinopathy. However, the mechanism(s) underlying this effect has not been fully elucidated. Bovine retinal capillary endothelial cells (BRECs), an in vitro model, were to investigate mechanism of RSV. Our results showed that high glucose induced significant cellular apoptosis BRECs, which was accompanied by increased intracellular levels reactive oxygen species (ROS) and cleaved caspase‐3. The glucose‐induced ROS elevation...
Curcumin possesses many pharmacological properties including anti-inflammatory effects. Although prior studies indicate that curcumin has beneficial effects for diabetic retinopathy, the mechanism of action is not known. To address this issue, we investigated effect against diabetes-induced retinal vascular damage and its by using cultured Müller cells stimulated with high glucose.We studied in vivo retinas rats rendered streptozotocin vitro glucose. We administered curcumin, or KN93, an...
Lung adenocarcinoma (LUAD) is the most common histological subtype of nonsmall-cell lung cancer. Herein, a multiomics method, which combined proteomic and N-glycoproteomic analyses, was developed to analyze normal cancerous bronchoalveolar lavage fluids (BALFs) from six LUAD patients identify potential biomarkers LUAD. The data-independent acquisition analysis first used BALFs, identified 59 differentially expressed proteins (DEPs). bioinformatic analyses DEPs have shown that marker protein,...
The potential mechanism of miRNA released from adipose-derived stem cell (ADSC)-derived micro vesicle (MV) onthe modulation proliferation, migration and invasion endothelial cells were explored. In this study, miR-210 level was detected by qT-PCR. Alix, VEGF RUNX3 expressions Western blot. human umbilical vein (HUVECs) observed MTT assay Transwell assay. Luciferase reporter gene conducted to validate the targeting activity MVs-released on RUNX3. We found hypoxia significantly increased...
Atherosclerosis is a chronic and progressive disease. Its morbidity mortality rates have demonstrated an increase in recent years. The present study aimed to explore the role of sirtuin (SIRT) 4 development atherosclerosis. Alterations SIRT4 expression response oxidized low density lipoprotein (oxLDL) were quantified human umbilical vein endothelial cells (HUVECs) using western blotting. Cell counting kit‑8 flow cytometry assays used order effects on HUVEC proliferation apoptosis. effect...
Phytoestrogen genistein may be useful to treat pulmonary arterial hypertension (PAH). However, its mechanism is still not clear. The aim of the present study was confirm therapeutic effects phytoestrogen on PAH in monocrotaline-induced rat model and explore mechanism.Sprague-Dawley male rats were randomly divided into 4 groups: control group (n=8), treament with three different doses (n=8 each dose group) PI3K inhibitor LY294002. induced by monocrotaline (MCT). situation survival observed....
The occurrence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. link between serum remnant cholesterol (RC) to high-density lipoprotein (HDL-C) ratio and NAFLD remains unclear. Therefore, we sought clarify the relationship RC/HDL-C NAFLD.
FGD5 antisense RNA 1 (FGD5‑AS1) is a long non‑coding in acute myocardial infarction (AMI), which primarily caused by ischemia‑hypoxia. Retinoid acid receptor‑related orphan receptor α (RORA) key protector maintaining heart function. However, the roles of FGD5‑AS1 and RORA AMI have not previously been elucidated. The present study investigated effect mechanism human cardiomyocyte AC16 cells under hypoxia. Reverse transcription‑quantitative PCR western blotting demonstrated that were...
To determine whether curcumin offers neuroprotection to minimize the apoptosis of neural cells in retina diabetic rats.Streptozotocin (STZ)-induced rats and control were used this study. A subgroup STZ-induced treated with for 12 weeks. Retinal histology, retina, electroretinograms, retinal glutamate content evaluated after levels Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), phospho-CaMKII (p-CaMKII), cleaved caspase-3 determined by Western blot analysis.The amplitudes a-wave,...
The aim of this study is to investigate the effects fenofibrate (FA) on microvascular dysfunction in retina diabetic rats, and determine underlying mechanism.Streptozotocin (STZ)-induced rats control were used study. A subgroup STZ-induced was treated orally with vehicle or FA (100 mg/kg/day) for 24 weeks along regular monitoring body weight serum parameters. At end 24-week treatment, retinal vascular permeability quantified by confocal microscopy using Evans blue as a tracer. Retinal...
Background: Long noncoding RNA taurine-upregulated gene 1 (TUG1) has been reported to involve in the processing of cardiac ischemia/reperfusion injury after myocardial infarction. Thus, this study further investigates underlying mechanisms TUG1 hypoxia/reoxygenation (H/R)-induced cardiomyocyte vitro. Methods: Cell viability, apoptosis, and migration invasion were detected using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, transwell respectively. Western...
Abstract Osteoglycin (Ogn), a class III SLRP member with multiple glycosylation sites, has been proposed to be engaged in cardiac dysfunction and adverse remodeling human heart failure following myocardial infarction. However, the underlying mechanism remains elucidated. Thus, we sought define role of Ogn regulation Wnt pathway on fibrosis epithelial/endothelial‐mesenchymal transformation (EMT/EndMT) mice myocarditis. The pathological changes are observed, while hematoxylin–eosin staining...
Objective To compare the curative effect of intravitreal injection triamcinolone acetonide and aflibercept on diabetic retinopathy (DR) cystoid macular edema. Methods A total 102 patients with DR edema admitted to hospital were enrolled between July 2018 2021. According random number table method, they divided into control group (intravitreal acetonide) observation aflibercept), 51 cases in each group. All followed up for half a year. The clinical effect, visual acuity, central subfield...
Although cryptococcal meningitis (CM) typically occurs in immunocompromised hosts, immunocompetent humans are susceptible to CM. In with an intact immune system, CM presents signs and symptoms typical of meningitis, including fever, headache neck stiffness. The present study reported the case a female patient who presented visual blurring both eyes bilateral papilledema for ~1 month. Following hospital admission, was diagnosed optic nerve inflammation treated intravenous methylprednisolone...
Abstract: Hypoxia leads to insufficient supply of blood and nutrients, which is major incentive for cardiomyocyte injury apoptosis. Previous studies reported the regulation effects microRNAs (miRNAs) in myocardial infarction, whereas function molecular mechanisms miR-322-5p were still unclear. Therefore, our study focused on biological role hypoxia-induced cardiac myoblast cells apoptosis injury. The expression levels cytokine-induced inhibitor 1 (CIAPIN1) measured by real-time quantitative...
The product of red cell distribution width (RDW) and mean corpuscular volume (MCV) has been identified as an indicator target organ damage in cases hypertension. However, the role RDW–MCV assessing carotid alteration, renal damage, left ventricular hypertrophy patients with hypertension not elucidated. In this cross-sectional study, a total 1115 participants were included. RDW MCV at admission measured using automated hematology analyzer. Organ was determined by mass index (LVMI),...
Purpose This study aimed to assess the causal relationships between vitamin D levels and ocular disorders. Methods Independent genetic variables were obtained from genome-wide association studies (GWAS) publicly available databases. The summary statistics for 25-hydroxyvitamin (25(OH)D) two large-scale GWAS studies, with sample sizes of 324,105 417,580 European individuals. variants myopia, primary open angle glaucoma (POAG), anterior iridocyclitis, senile cataract, diabetic retinopathy...
Purpose: The purpose of this article is to describe a modified lacrimal bypass with porous polyethylene-coated Jones tube. Methods: A total 180 patients (180 eyes) nonreconstructable obstruction underwent tube through retrocaruncular-middle meatus tract approach endoscopic assistance. All were followed up at least for 24 months. Success rate was analyzed and complications recorded. Results: 174 finally included. Duration surgery ranged from 28 47 minutes (mean 37.2 ± 4.2 minutes). mean...
Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. The present study aimed to elucidate the pathological role of long non-coding RNA (lncRNA) paternally expressed 13 (PEG13) in onset progression atherosclerosis. Specifically, its effects on human umbilical vein cell (HUVEC) proliferation, angiogenesis, senescence senescence-associated secretory phenotype (SASP)-related factors were investigated using cellular β-galactosidase...
A certain dosage of cyclophosphamide (CYP) in clinical applications contributes to severe cardiotoxicity. Herein, this study explored the impact adipose-derived mesenchymal stem cell (AdMSC)-exosomes (Exos) on CYP-induced cardiotoxicity.AdMSCs and AdMSCs-Exos were isolated identified. CYP was utilized for developing a cardiotoxicity rat model, after which blood collected then serum contents cardiac injury-related indexes (creatine kinase-MB, lactate dehydrogenase, aspartate aminotransferase,...