A5100713914- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Pancreatic function and diabetes
- Redox biology and oxidative stress
- Biochemical and Molecular Research
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Catalytic Cross-Coupling Reactions
- Acute Lymphoblastic Leukemia research
- Ultrasound Imaging and Elastography
- Fatty Acid Research and Health
- Retinoids in leukemia and cellular processes
- Medical Image Segmentation Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Pulmonary Hypertension Research and Treatments
- Renin-Angiotensin System Studies
- Diabetes Management and Research
- Ion Transport and Channel Regulation
- Cardiac Ischemia and Reperfusion
First Affiliated Hospital of Nanchang University
2015-2021
Nanchang University
2008-2021
Guangdong Pharmaceutical University
2021
Sun Yat-sen University
2011-2019
The First Affiliated Hospital, Sun Yat-sen University
2011-2019
Sixth Affiliated Hospital of Sun Yat-sen University
2019
University of Maryland, Baltimore
2012
Cardiac hypertrophy is one of the major risk factors cardiovascular morbidity and mortality. Autophagy acknowledged to be an important mechanism regulating cardiac hypertrophy. Sestrin 1, a downstream target gene p53, has been proven regulate autophagy. However, role 1 in remains unknown. Our study showed that mRNA protein expression declined pressure overload phenylephrine (PE)-induced Knockdown by RNAi deteriorated PE-induced hypertrophy, whereas overexpression adenovirus transfection...
Objectives Serum neurofilament light chain (NfL) is a biomarker for neuroaxonal damage, and S100B blood marker cerebral damage. In the present study, we investigated relationship between serum NfL levels, severity, outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods We prospectively recruited aSAH healthy controls January 2016 2021. Clinical results included mortality poor (modified Rankin scale score of 3-6) after 6 months. The ultrasensitive Simoa technique was...
Phytoestrogen genistein may be useful to treat pulmonary arterial hypertension (PAH). However, its mechanism is still not clear. The aim of the present study was confirm therapeutic effects phytoestrogen on PAH in monocrotaline-induced rat model and explore mechanism.Sprague-Dawley male rats were randomly divided into 4 groups: control group (n=8), treament with three different doses (n=8 each dose group) PI3K inhibitor LY294002. induced by monocrotaline (MCT). situation survival observed....
Background: The bone marrow microenvironment constitutes a sanctuary for leukemia cells. Recent evidence indicates that environment-mediated drug resistance arises from reciprocal influence between tumor cells and the surrounding stroma. present study aimed to investigate effect of chronic lymphocytic (CLL) on metabolism stroma, determine role this metabolic change in stroma vorinostat CLL cells, thus assess novel strategy target achieve maximum therapeutic vorinostat. Methods: To evaluate...
An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils arylboronic acids by a tandem copper( i )-catalyzed electrophilic amination/Ag( )-mediated oxidative annulation strategy.
Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia, and currently incurable due to drug resistance. A previous study indicated that redox interaction between bone marrow stromal cells profoundly affected CLL cell viability response. The present aimed further investigate effect on resistance in microenvironment, assess a novel redox-mediated strategy eliminate stromal-protected cells, thus achieve maximum therapeutic efficacy antileukemic drugs. Histone deacetylase...