A5052028542- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Radioactive element chemistry and processing
- NF-κB Signaling Pathways
- Extracellular vesicles in disease
- Retinal and Optic Conditions
- Photoacoustic and Ultrasonic Imaging
- Regional Development and Environment
- Coastal and Marine Management
- Nanoplatforms for cancer theranostics
- Nitric Oxide and Endothelin Effects
- Clusterin in disease pathology
- Natural Compounds in Disease Treatment
- Advanced Glycation End Products research
- Phagocytosis and Immune Regulation
- Chemical Synthesis and Characterization
- Heme Oxygenase-1 and Carbon Monoxide
- Arctic and Russian Policy Studies
- Systemic Lupus Erythematosus Research
- Extraction and Separation Processes
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
National Clinical Research Center for Digestive Diseases
2023
Uveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from Hedyotis diffusa, known for its notable anti-inflammatory antioxidant characteristics. The present study explored potential effects fundamental processes of ASPA by injecting it or placebo into vitreous rats endotoxin-induced uveitis (EIU). severity was assessed using clinical scores obtained through slit lamp examination....
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Oxidative stress-prompted degeneration of the retinal pigment epithelium (RPE) notably contributes to onset age-related macular (AMD). However, pathways leading RPE deterioration and possible preventative strategies are not yet completely comprehended. Ferroptosis was assayed through evaluation lipid peroxidation (C11-BODIPY MDA), reactive oxygen species (ROS), transmission electron microscopy (TEM), iron content measurement, q-PCR, western blotting, immunofluorescence. To assess structure...
Among aging adults, age-related macular degeneration (AMD), is a prevalent cause of blindness. Nevertheless, its progression may be halted by antioxidation in retinal pigment epithelium (RPE). The primary effective constituent Tripterygium wilfordii Hook. F., triptolide (TP), has demonstrated anti-inflammatory, antiproliferative, and antioxidant properties. mechanics the protective effect against oxidative damage epithelial (RPE) were assessed this study.
Neutrophils participate in the advancement of human innate immune system and respond to perceived endogenous exogenous threats. As a response mechanism, neutrophil extracellular traps (NETs) form near pathogens surrounding tissues during an response. Drusen is important marker Age-Related Macular Degeneration (AMD) plays role course AMD. Aβ1-40 main component drusen. However, relationship between NETs AMD or unclear. Here, we found elevated levels serum patients mouse models. We also...
In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm size, that are within range cellular molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs overcome obstacles, target drug delivery, prolong release, reduce toxicity, be used gene therapy. After brief introduction classification NPs, we will focus potential applications...
Abstract Age-related macular degeneration (AMD) is one of the three major blindness diseases. Retinal pigment epithelium (RPE) dysfunction due to smoking an essential environmental factor in pathogenesis AMD. Ferroptosis a novel type iron-dependent programmed cell death (PCD). However, relationship between cigarette smoke extract (CSE)-induced RPE damage and ferroptosis remains unclear. In this study, we observed that CSE induced cellular human retinal epithelial line (ARPE-19), resulting...