A5033869618- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Retinal and Optic Conditions
- Photoacoustic and Ultrasonic Imaging
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Ocular Diseases and Behçet’s Syndrome
Chongqing Medical University
2022-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2023
Purpose: To explore the mechanism underlying IL-8-induced neutrophil extracellular trap (NET) formation in patients with ocular-active Behçet's disease (BD) and effect of inhibiting NET on severity inflammation experimental autoimmune uveitis (EAU) mice. Methods: The serum DNA elastase (NE) IL-8 levels BD, expression myeloperoxidase, NE, histone H3Cit IL-8–induced neutrophils isolated from healthy controls, effects NETs HMC3 cells were detected. Female C57BL/6J mice immunized IRBP651–670 to...
Neutrophils participate in the advancement of human innate immune system and respond to perceived endogenous exogenous threats. As a response mechanism, neutrophil extracellular traps (NETs) form near pathogens surrounding tissues during an response. Drusen is important marker Age-Related Macular Degeneration (AMD) plays role course AMD. Aβ1-40 main component drusen. However, relationship between NETs AMD or unclear. Here, we found elevated levels serum patients mouse models. We also...
In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm size, that are within range cellular molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs overcome obstacles, target drug delivery, prolong release, reduce toxicity, be used gene therapy. After brief introduction classification NPs, we will focus potential applications...