A5100670130- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Maternal and fetal healthcare
- Genomic variations and chromosomal abnormalities
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis B Virus Studies
- Pregnancy-related medical research
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Hemoglobinopathies and Related Disorders
- Pregnancy and Medication Impact
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- Cardiovascular Issues in Pregnancy
- Liver Disease Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Venous Thromboembolism Diagnosis and Management
- Hepatitis Viruses Studies and Epidemiology
Xiamen University
2025
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Beijing Forestry University
2024
Chinese Academy of Agricultural Sciences
2024
Monash University Malaysia
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guangdong Medical College
2023
University of Electronic Science and Technology of China
2022
Xinjiang University
2022
Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing diseases, but role gut microbiome in pathogenesis PE remains unknown.We performed a case-control study to compare faecal and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address causative relationship between PE, we used microbiota transplantation (FMT) an antibiotic-treated mouse model. Finally, determined translocation immune...
To report the performance of massively parallel sequencing (MPS) based prenatal noninvasive fetal trisomy test on cell-free DNA from maternal plasma in a routine clinical setting China.The MPS-based was offered as screening for trisomies 21 and 18 to pregnant women 49 medical centers over 2 years. A total 11,263 participants were recruited performed 11,105 pregnancies. Fetal outcome data obtained after expected date confinement.One hundred ninety cases classified positive, including 143 47...
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous array cervical squamous cell carcinoma (CSCC) clinical specimens identified upregulation miR-221-3p. Here, we show that miR-221-3p is closely correlated with peritumoral lymphangiogenesis and lymph node (LN) metastasis CSCC. More importantly, characteristically enriched transferred by CSCC-secreted exosomes into human lymphatic endothelial cells (HLECs) to promote HLECs...
The accumulation of tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is associated with malignant progression cancer. However, mechanisms by which TME facilitates TAM infiltration are not fully understood. This study showed that high ZEB1 expression cervical cancer cell islets was positively correlated CD163
Background: Patients with preeclampsia display a spectrum of onset time and severity clinical presentation, yet the underlying molecular bases for early-onset late-onset subtypes are not known. Although several transcriptome studies have been done on placentae from PE patients, only small number differentially expressed genes identified due to very sample sizes no distinguishing subtypes. Methods: We carried out RNA-seq 65 high-quality placenta samples, including 33 30 patients 32 control...
Fetuses diagnosed with fetal growth restriction (FGR) are at an elevated risk of stillbirth and adulthood morbidity. Gut dysbiosis has emerged as one the impacts placental insufficiency, which is main cause FGR. This study aimed to characterize relationships among intestinal microbiome, metabolites, Characterization was conducted on gut fecal metabolome, human phenotypes in a cohort 35 patients FGR normal pregnancies (NP). The serum metabolome analyzed 19 31 pregnant women. Multidimensional...
To compare the performance of traditional G-banding karyotyping with that copy number variation sequencing (CNV-Seq) for detection chromosomal abnormalities associated miscarriage.Products conception (POC) were collected from spontaneous miscarriages. Chromosomal detected using high-resolution and CNV sequencing. Quantitative fluorescent polymerase chain reaction analysis maternal POC DNA short tandem repeat (STR) markers was used to both monitor cell contamination confirm status sex...
Molecular basis of ovarian folliculogenesis and etiopathogenesis premature failure (POF), a common cause infertility in women, are not fully understood. Mechanistic target rapamycin complex 2 (mTORC2) is emerging as central regulator cell metabolism, proliferation, survival. However, its role POF has been reported. Here, we showed that the signaling activity mTORC2 inhibited 4-vinylcyclohexene diepoxide (VCD)-induced mouse model. Notably, mice with oocyte-specific ablation Rictor, key...
Many human diseases share a developmental origin that manifests during childhood or maturity. Aneuploid syndromes are caused by supernumerary reduced number of chromosomes and represent an extreme example disease, as they have devastating consequences before after birth. Investigating how alterations in gene dosage drive these conditions is relevant because it might help treat some clinical aspects. It may also provide explanations to quantitative differences expression determine phenotypic...
Abstract Objective To develop an accurate non‐invasive prenatal test using next generation sequencing (NGS) for HbE and the four most common β‐thalassaemia mutations found in South East Asia (namely −28A > G, CD17A T, CD41/42(−TTCT) IVS‐II‐654C T). Methods Cell‐free DNA was extracted from maternal plasma 83 families where both parents were carriers of mutation or one mutations. Overlapping PCR amplicons covering each generated, pooled sequenced Illumina MiSeq. Fastq files analysed to...
Accumulating evidence suggests that the pathogenesis of preeclampsia involves poor placentation caused by insufficient trophoblast invasion and impaired uterine spiral artery remodeling, yet underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from preeclamptic patients normal subjects, identified about four hundred long non-coding RNAs differentially expressed in with early-onset severe preeclampsia. Here, we report our identification lncRNA...
Abstract Background Prenatal exposure to intrauterine inflammation (IUI) is a crucial event in preterm birth (PTB) pathophysiology, increasing the incidence of neurodevelopmental disorders. Gut microbiota and metabolite profile alterations have been reported be involved PTB pathophysiology. Method results In this study, IUI-exposed mouse model was established verified by rate other perinatal adverse reactions; LPS-indued IUI significantly increased rates PTB, apoptosis placenta tissue...
The purpose of this study was to examine instructor immediacy in the Chinese and American classrooms, its relationship with student learning. Participants were 302 undergraduate university students (140 enrolled at Peking University Beijing, China; 162 a large Midwestern university). Results indicated that (a) who received instruction from instructors perceived lower amount nonverbal than instructors, (b) verbal (c) affective cognitive learning is slightly correlated particular behaviors.
Objective. To determine plasma markers of oxidative stress during the second and third trimester pregnancy in patients with gestational diabetes mellitus (GDM). Study Design. We conducted a prospective nested case-control study involving 400 pregnant women, 22 whom developed GDM. As control group, 30 normal women were chosen randomly. Plasma samples analyzed for 8-iso-prostaglandin F2 α (8-iso-PGF2 ), advanced protein products (AOPPs), carbonyl (PCO), glutathione peroxidase-3 (GPX-3),...
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast invasion, leading uterine spiral artery remodeling and angiogenesis. However, the underlying molecular mechanism remains unknown. We recently carried out transcriptome profiling of placental long noncoding RNAs (lncRNAs) identified 383 differentially expressed lncRNAs in early-onset severe preeclampsia. Here, we are reporting our identification lncRNA INHBA-AS1 as a potential causal factor...
Successful expansion of hematopoietic stem cells would benefit the use cell transplants in clinic. Several angiopoietin-like proteins, including 7, can support activity cells. However, effects ANGPTL7 on human and downstream signaling cascade activated by are poorly understood. Here, we established a progenitor cell-supportive mouse fetal liver line that specifically expressed Angptl7 protein. Furthermore, found is capable stimulating increasing repopulation activities progenitors...
Accumulation of advanced oxidation protein products (AOPPs) is prevalent in obesity, maternal age, diabetes mellitus, and polycystic ovary syndrome. Alterations the regulation signaling angiogenic pathways have been recognized as a link between these conditions pre-eclampsia. To investigate possible impact AOPPs on soluble Fms-like tyrosine kinase 1 (sFlt-1) expression trophoblasts. A trophoblast cell line (HRT-8/SVneo) was treated with various concentrations AOPPs. The mRNA sFlt-1, vascular...
The lymphocyte-to-monocyte ratio (LMR), as a surrogate marker of systemic inflammation, has been found to be novel prognostic indicator in various malignancies. Data from 672 advanced epithelial ovarian cancer (EOC) patients treated with neoadjuvant chemotherapy (NAC) followed by debulking surgery were analyzed, and the value LMR evaluated. optimal cutoff point prediction survival was defined 3.45 through receiver operating characteristics curve analysis. Patients low (≤3.45) at diagnosis...