A5100453413- Traditional Chinese Medicine Analysis
- Medicinal Plants and Neuroprotection
- Phytochemical and Pharmacological Studies
- Cholinesterase and Neurodegenerative Diseases
- Medical Research and Treatments
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Oral microbiology and periodontitis research
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Studies
- Essential Oils and Antimicrobial Activity
- Ginseng Biological Effects and Applications
- Biological and pharmacological studies of plants
- Antioxidant Activity and Oxidative Stress
- Garlic and Onion Studies
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Chromatography in Natural Products
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Cardiac Ischemia and Reperfusion
- Flavonoids in Medical Research
- Natural Antidiabetic Agents Studies
Shaanxi Provincial People's Hospital
2024
Dazhou Academy of Agricultural Sciences
2023
State Ethnic Affairs Commission
2023
Southwest Minzu University
2023
McGill University
2023
Anhui Medical University
2023
Xuzhou University of Technology
2022
Xuzhou College of Industrial Technology
2022
Guangdong Pharmaceutical University
2017-2022
Guangdong Medical College
2022
A 70% ethanol–water extract from the leaves of Mangifera indica L. (Anacardiaceae) inhibited triglyceride (TG) accumulation in 3T3-L1 cells. From active fraction, seven new benzophenone C-glycosides, foliamangiferosides (1), A1 (2), A2 (3), B (4), C1 (5), C2 (6), and C3 (7), together with five known compounds were isolated structures elucidated on basis chemical physicochemical evidence. The effects these TG free fatty acid level cells determined, structure–activity relationship was...
Tanshinone IIA (Tan-IIA) is derived from the dried roots of Salvia miltiorrhiza Bunge, a traditional Chinese medicine. Although has been applied for many years, toxicity mono-constituent miltiorrhiza, tanshinone IIA, still understudied. This study evaluated cardiotoxicity and developmental malformations Tan-IIA by using zebrafish normal embryos dechorionated embryos. After treatment with in different concentrations four-day periods, obvious pericardial edema, spinal curvature, even missing...
Seabuckthorn carpenter moth, Eogystia hippophaecolus (Lepidoptera: Cossidae), is an important pest of sea buckthorn (Hippophae rhamnoides), which a shrub that has significant ecological and economic value in China. E. highly cold tolerant, but limited studies have been conducted to elucidate the molecular mechanisms underlying its resistance. Here we sequenced transcriptome using RNA-Seq technology performed de novo assembly from short paired-end reads. We investigated larval response stress...
Quantitative fingerprint and differences of Artemisia argyi from different varieties, picking time, aging year, origins were analyzed combing with chemometrics. The antioxidant activity was determined markers screened. Variety WA3 significantly that the other varieties. Fingerprint peak response A. picked in December lower than samples collected May August. Fresh leaves superior to withered stems. 1-5 years presented a classification trend. Antioxidant produced Nanyang generally others...
Thrombotic diseases have high disability rates, mortality and seriously endanger human health safety. Platelets play an important role in the process of thrombus formation. Salvia miltiorrhiza has been widely recognized clinical practice both domestically internationally for its ability to promote blood circulation, remove stasis, antioxidant, anti-platelet aggregation, anti-atherosclerosis effects. Due multi-component, multi-pathway, multi-target characteristics aggregation mechanism...
Astragalus membranaceus is a traditional Chinese medicine derived from the roots of (Fisch.) Bge., which has same medicinal and edible uses in China. It also widely used daily food, its pharmacological effects mainly include antioxidant effects, vascular softening etc. Currently, it increasingly prevention hypertension, cerebral ischemia, stroke Formononetin glucopyranoside (ononin) are both important components membranaceuss may play roles treatment cardiovascular diseases (CVDs). This...
A simple and reliable method for distinguishing Danshen is important to evaluate the quality clinical efficiency of these species. An HPLC was developed determination protocatechuic aldehyde, salvianolic acid A, B, cryptotanshinone, tanshinone I IIA in 23 samples Salvia. The analytes were separated on an Agilent XDB C18 reversed-phase column coupled with a Phenomenex guard using gradient elution acetonitile–0.1% aqueous phosphoric as mobile phase at flow rate 0.8 mL/min UV detection 280 nm....
Abstract Pingxiao capsule (PXC) is a herbal medicine used for adjuvant therapy in breast cancer. However, the constituents and absorbed components of formula their related metabolites have not been elucidated to date. PXC typical traditional Chinese consisting Strychnos nux‐vomica L., Curcuma wenyujin Y. H., Agrimonia pilosa Ledeb., Toxicodendron vernicifluum , Trogopterus dung, alumen, potassium nitrate (saltpeter) Citrus aurantium L. In this study, ultra‐high performance liquid...
In this study, ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and gas chromatography-mass spectrometry(GC-MS) were combined with non-targeted metabonomic analysis based on multivariate statistics analysis, the content of five indicative components in nardosinone was determined compared by UPLC. The main chemical Nardostachyos Radix et Rhizoma imitative wild cultivation comprehensively analyzed. results statistical spectrometry(LC-MS) GC-MS...
Previous studies reported that sea buckthorn (Hippophae rhamnoides L., Elaeagnaceae, HRP) exhibits hepatoprotective effects via its anti-inflammatory and antioxidant properties as well inhibitory on collagen synthesis. However, it is unclear whether this effect also achieved by regulating liver drug metabolism enzyme pathways. Herein, we examined the regulatory of HRP cytochrome P450 3A (CYP3A) in rats with immune injury, explored molecular mechanism effect. Rat models immunological injury...
A high-performance liquid chromatography (HPLC) method has been developed for the simultaneous identification and quantification of active compounds (cryptotanshinone, dihydrotanshinone I, tanshinone IIA, salvianolic acid A, B, protocatechuic aldehyde, rosmarinic acid) contained in traditional Chinese folk medicine Salvia przewalskii Maxim. The herb samples (including wild, cultivated, yin pian) from fourteen main regions were investigated. Chromatographic separation was performed on an...
This project was launched to and establish the wavelength overlapping HPLC fingerprint for Danshen determine contents of 7 component in Danshen. The chromatographic fingerprints were built by using Agilent Eclipse Plus C_(18)( 4. 6 mm×100 mm,3. 5 μm) as stationary phase 0. 1% formic acid solution( A)-acetonitrile( B) mobile with gradient elution( 0-5 min,10%-20% B; 5-20 min,20%-30% 20-25 min,30%-50% 25-40 min,50%-65% 40-45 min,65%-80% 45-46 min,80%-10% 46-50 min,10% at a flow rate 1...
Allyl isothiocyanate (AITC) in food products such as wasabi is commonly analyzed by gas chromatography/mass spectrometry (GC/MS), while liquid (LC/MS) more suitable for the polar metabolites. The development of an effective method simultaneous determination AITC and its phase II metabolites needed to support drug metabolism pharmacokinetics (DMPK) studies.Derivatization reaction with N-(tert-butoxycarbonyl)-L-cysteine methyl ester (t BocCysME) was used ultra-high-performance...
The dried root and rhizome of Salvia miltiorrhiza (Lamiaceae: Salvia), one the popular traditional Chinese medicine (TCM), is officially listed in Pharmacopoeia under name Danshen 1 .S. have been widely used for treatment coronary heart disease, cerebrovascular bone loss, hepatitis, hepatocirrhosis chronic renal failure 2-6 .Although only S. was recorded Pharmacopoeia, other species containing brevilabra, castana, cavaleriei, cavaleriei var.simpliciflia, digitaloides, paohsingensis, plebeia,...
To investigate the effects of inhibiting proliferation and inducing apoptosis low-dose triptolide sorafenib alone or in combination on FLT3-ITD+ acute myeloid leukemia cell line MV4-11 STAT5 pathway.The cells were treated with low dose triptolide(IC20) sorafenib(IC50) for 48 hours. The inhibition detected by using CCK-8 kit, was flow cytometry, expression FLT3,STAT5 mRNA protein levels RT-PCR Western blot respectively.The treatment hours could inhibit induce apoptosis, moreover inhibitory...
目的 探讨高原驻训官兵作业疲劳状况及相关因素。 方 法 采用作业疲劳症状自评量表(WRFFQ)、军人心理应激自评问卷(PSET)、匹兹堡睡眠质量指数量表(PSQI)和状态-特质焦虑量表(STAI)对在高原驻训3个月后的465名官兵进行调查研究。 结果 ①高原驻训官兵作业疲劳总均分为(36.32±11.52)。②高原驻训官兵作业疲劳与心理应激、睡眠质量、状态焦虑和特质焦虑呈显著正相关(r分别为0.637、0.465、0.402、0.404，P＜0.01)。③作业疲劳高分组在心理应激、睡眠质量、状态焦虑和特质焦虑的得分显著高于低分组(P＜0.01)。④心理应激、特质焦虑和睡眠质量可以有效预测驻训官兵的作业疲劳状况，总解释量为46.1%。 结论 高原驻训官兵的作业疲劳状况与心理应激、睡眠质量和特质焦虑密切相关。
<p>Addition of NA rescued the inhibitory activity LSN3154567.</p>
<p>Addition of NA rescued the inhibitory activity LSN3154567.</p>
<p>Addition of NA rescued the inhibitory activity LSN3154567.</p>