A5029844338- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Chromatography in Natural Products
- Computational Drug Discovery Methods
- Healthcare and Venom Research
- Ubiquitin and proteasome pathways
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Studies
- Sphingolipid Metabolism and Signaling
- Microbial Metabolism and Applications
- Phytochemistry and Biological Activities
- Pharmacogenetics and Drug Metabolism
- Biochemical Analysis and Sensing Techniques
- Bioinformatics and Genomic Networks
- Drug Transport and Resistance Mechanisms
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Receptor Mechanisms and Signaling
- Ginger and Zingiberaceae research
- interferon and immune responses
Tianjin University of Traditional Chinese Medicine
2018-2024
Wenzhou Medical University
2023
Urumqi General Hospital of PLA
2013
Abstract Background Essential hypertension (EH) is a complex disease as consequence of interaction between environmental factors and genetic background, but the pathogenesis EH remains elusive. The emerging tools network medicine offer platform to explore at system level. In this study, we aimed identify key proteins biological regulatory pathways involving in further molecular connectivities these by topological analysis Protein-protein (PPI) network. Result extended including one giant...
Abstract Introduction The roots of Polygonum multiflorum (PM) serve as a classical traditional Chinese medicine (TCM), which has multiple biological activities. However, many cases hepatotoxicity in PM have been reported recent years. Processing with black beans decoction is one the typical processing methods to reduce since ancient times. Objectives To find potential effective constituents, well optimal variety and origin for PM. Methods Based on ultrahigh‐performance liquid chromatography...
Abstract Pingxiao capsule (PXC) is a herbal medicine used for adjuvant therapy in breast cancer. However, the constituents and absorbed components of formula their related metabolites have not been elucidated to date. PXC typical traditional Chinese consisting Strychnos nux‐vomica L., Curcuma wenyujin Y. H., Agrimonia pilosa Ledeb., Toxicodendron vernicifluum , Trogopterus dung, alumen, potassium nitrate (saltpeter) Citrus aurantium L. In this study, ultra‐high performance liquid...
Traditional Chinese medicine injections have been widely used in China for the treatment of various diseases. Transporter-mediated drug-drug interactions are a major contributor to adverse drug reactions. However, research on transporter-mediated injection-drug is limited. Shuganning injection treating liver In this study, we investigated inhibitory effect and its four main ingredients (baicalin, geniposide, chlorogenic acid, oroxylin A) 9 transporters. strongly inhibited organic anion...
Background. Polygonum Multiflorum Radix Preparata (PMP), prepared from multiflorum Thunb. (PM), is traditionally valued for its liver and kidney-tonifying effects. However, the previous studies showed that PMP was hepatotoxic, which limited clinical use. Unfortunately, potential hepatotoxic ingredients molecular mechanism are still uncertain. Objective. The aim of this study to find out biomarkers hepatotoxicity using metabolomics profile. Materials Methods. 60% ethanol extract (PMPE)...
Peptides are a class of protein fragments with relatively high biological activity and intense specificity, which play crucial role in the treatment Shuxuetong injection (SXT). However, extraordinary complexity Chinese medicinal formulates lack systematic identification methods primary challenges for study pharmacodynamic peptides . In addition, infinitesimal contents further hinder structural characterization polypeptide by traditional means. this paper, we described strategy that LC-MS...
Peiyuan Tongnao capsule (PTC) plays an important role in clinical application due to its excellent curative efficacy the treatment of ischemic stroke and chronic cerebral circulation insufficiency. To standardize rationalize PTC, a rapid sensitive method based on ultra-high performance liquid chromatography/quadrupole-Orbitrap mass spectrometry with parallel reaction monitoring (PRM) mode was developed validated for pharmacokinetic (PK) study. Ten bioactive compounds (aucubin, salidroside,...
Peptides are a class of protein fragments with relatively high biological activity, strong specificity. Some them have stimulated considerable interest because their unique advantages in many diseases. Modern studies shown that multiple anticoagulant play crucial role Shuxuetong injection (SXT). However, the extraordinary complexity Chinese medicinal formulate and lack identification method primary challenges for ingredients. In addition, infinitesimal peptides contents further hinder...