A5013432318- Genetics, Aging, and Longevity in Model Organisms
- Viral Infectious Diseases and Gene Expression in Insects
- Nanoparticles: synthesis and applications
- Proteins in Food Systems
- Curcumin's Biomedical Applications
- Invertebrate Immune Response Mechanisms
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Advancements in Transdermal Drug Delivery
- Insect Resistance and Genetics
- Pharmacological Effects of Natural Compounds
- Probiotics and Fermented Foods
- Ginseng Biological Effects and Applications
- Bee Products Chemical Analysis
- Membrane Separation Technologies
- Advanced Drug Delivery Systems
- Insect Utilization and Effects
- biodegradable polymer synthesis and properties
- Microbial Metabolic Engineering and Bioproduction
- Phytochemistry and biological activity of medicinal plants
- Electrospun Nanofibers in Biomedical Applications
- Advanced Chemical Sensor Technologies
- Gut microbiota and health
- thermodynamics and calorimetric analyses
- Diet and metabolism studies
Myongji University
2014-2024
Seoul National University
2002-2006
Nanomaterials are extensively used in consumer products and medical applications, but little is known about their environmental biological toxicities. Moreover, the toxicity analysis requires sophisticated instruments labor-intensive experiments. Here we report a microfluidic chip incorporated with nematode Caenorhabditis elegans that rapidly displays changes body growth gene expression specifically responsive to silver nanoparticles (AgNPs). C. were cultured chambers presence or absence of...
Parkinson's disease is one of the most common degenerative disorders and characterized by observable motor dysfunction loss dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating beneficial to improving its aqueous solubility bioavailability. The curcumin-loaded HSA were acquired in particle size at zeta potential 200 nm -10 mV, respectively. ameliorated features C. elegans model, including body movement, basal...
Abstract Many studies on preventing apoptosis have been carried out from the viewpoint of anti‐apoptotic cloned‐gene expressions inside cells, whereas in this study, we investigated inhibition by addition silkworm hemolymph, a natural compound, outside cells. In previous reported effect hemolymph baculovirus‐induced insect cell apoptosis. Using vaccinia virus‐HeLa system as model found that serum, inhibits not only but also human system. The virus‐induced HeLa was analyzed using DNA...
It was previously reported that silkworm hemolymph (SH) inhibits apoptosis and increases the production of recombinant human erythropoietin (EPO) in Chinese hamster ovary (CHO) cells. The apoptosis-inhibiting component SH is a member 30K protein family. In this study, CHO cell line producing EPO manipulated genetically to express 30Kc6 gene encoding silkworm, Bombyx mori. transient expression significantly suppressed death induced by serum deprivation. A stable expressing with an...
Diets based on carbohydrates increase rapidly the blood glucose level due to fast conversion of glucose. High diets have been known induce many lifestyle diseases. Here, we demonstrated that high diet shortened lifespan Caenorhabditis elegans through apoptosis induction. Control adult groups without lived for 30 days, whereas animals fed 10 mg/L D-glucose only 20 days. The reduction by showed a dose-dependent profile in concentration range from 1 mg/L. Aging effect was examined measurement...
In this current research, mesoporous nano-hydroxyapatite (HAp) and F-doped hydroxyapatite (FHAp) were effectively obtained through a citric acid-enabled microwave hydrothermal approach. Citric acid was used as chelating modifying agent for tuning the structure porosity of HAp structure. This is first report to use modifier producing nano FHAp. The samples characterized by different analyses. XRD data revealed that F incorporated well into crystal crystallinity improved unit cell volume...
To produce erythropoietin (EPO), Chinese hamster ovary (CHO) cells were first cultured in a medium containing FBS (growth medium) and then serum-free sodium butyrate (production medium). Sodium increases recombinant protein production, but also induces apoptosis, which reduces cell viability productivity. In previous study, we found that silkworm hemolymph (SH), an insect serum, inhibits the apoptosis of mammalian cells. overcome butyrate-induced added SH to growth medium. This pretreatment...
Because the freshness of seafood determines its consumer preference and food safety, rapid monitoring deterioration is considered essential. However, conventional analysis using chromatography instruments bacterial colony counting depends on time-consuming food-destructive treatments. In this study, we demonstrate a non-destructive system by triangular study sensory evaluation, gas chromatography-mass spectroscopy (GC-MS), bioelectronic nose. The evaluation indicated that acceptability...
Abstract BACKGROUND Hybrid materials are being developed with improved separation properties as pervaporation ( PV ) membranes. Mixed matrix membranes MMMs containing surface‐functionalized fumed silica SiO 2 nanoparticles in polydimethylsiloxane PDMS were investigated for recovery of 1‐butanol. The characterized through water contact angle, pure 1‐butanol sorption, degree swelling and partition coefficients . Results Most outperformed the 1.5% (w/v) at ≤40°C. Functionalized fillers enhanced...
Gut microbiota are known to play an important role in obesity. Enterobacter cloacae, a Gram-negative bacterium, has been considered pathogenic bacterium related obesity the gut. In this study, we established model of C. elegans by feeding E. cloacae combined with high glucose diet (HGD), which significantly induced lipid accumulation. An anti-lipid mechanism study revealed that fatty acid composition and expression level fat metabolism-related genes were altered under HGD conditions. Lactic...
Lessons from the recent COVID-19 pandemic underscore importance of rapidly developing an efficacious vaccine and its immediate administration for prophylaxis. Oral vaccines are particular interest, as presence healthcare professionals is not needed this stress-free vaccination approach. In study, we designed a chitosan (CH)-alginate (AL) complex carrier system encapsulating inactivated influenza virus (A/PR/8/34, H1N1), efficacy these orally administered nanocomposite was evaluated in mice....
Nanoparticles (NPs) may have great potential for various subsurface applications, including oil and gas recovery, reservoir imaging, environmental remediation. One of the important challenges these downhole applications is to achieve colloidal stability in media at high salinity temperature. It has been previously shown that several functional NPs "multipoint"-grafted with anionic poly(2-acrylamido-2-methyl-1-propanesulfonate-co-acrylic acid; AMPS-co-AA) exhibited remarkable stabilities...