A5012199072- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Pluripotent Stem Cells Research
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Silk-based biomaterials and applications
- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Insect Resistance and Genetics
- Acute Lymphoblastic Leukemia research
- Proteins in Food Systems
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Phagocytosis and Immune Regulation
- Protein Interaction Studies and Fluorescence Analysis
Anyang University
2021-2024
Hanyang University
2021-2024
Korea University
2024
Kangwon National University
2018-2021
Boston Children's Hospital
2018
Harvard University
2018
Seoul National University
2008-2017
Abstract Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to complex ex vivo cell‐manufacturing procedures and low therapeutic efficacy against solid tumors. The limited effects partially CAR‐T infiltration tumors inactivation of cells by the immunosuppressive tumor microenvironment. Here, a facile approach is presented in program macrophages, which can...
Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus bacteria, but its association with diminished cholesterol levels in COVID-19 patients unknown. Here, we evaluated SREBP-2 activation peripheral blood mononuclear cells of and verified the function COVID-19. Intriguingly, report first observation C-terminal fragment patients' propose an indicator for determining severity. We confirmed that SREBP-2-induced biosynthesis was suppressed...
Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan address these issues. Glycol is natural adjuvant, inducing dendritic cell activation promote T helper 1 immune responses, macrophage activation, cytokine production. Effective antigen production by cells initiates T-cell-mediated aiding growth control.
The current outbreak of the beta-coronavirus (beta-Cov) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019. No specific antiviral treatments or vaccines are currently available. A recent study has reported that disease 2019 (COVID-19), caused by SARS-CoV-2 infection, is associated with neutrophil-specific plasma membrane rupture, and release excessive neutrophil extracellular traps (NETs) DNAs (eDNAs). This mechanism involves activation NETosis, a programmed...
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on a global scale urges prompt and effective countermeasures. Recently, study has reported that disease-19 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with decrease in albumin level, an increase NETosis, blood coagulation, cytokine level. Here, we present drug-loaded nanoparticles as therapeutic agent to resolve clinical outcomes observed patients. PEGylated nanoparticle albumin-bound...
Abstract Background Basic fibroblast growth factor (bFGF) is one of the critical components accelerating angiogenesis and tissue regeneration by promoting migration dermal fibroblasts endothelial cells associated with matrix formation remodeling in wound healing process. However, clinical applications bFGF are substantially limited its unstable nature due to rapid decomposition under physiological microenvironment. Results In this study, we present bFGF-loaded human serum albumin...
Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle profitable gene therapy. Lipid nanoparticles (LNPs), considered prospective vehicle nucleic acid delivery, have demonstrated efficacy in human use during the COVID-19 pandemic. This study introduces novel biomaterial-based platform, M1-polarized macrophage-derived cellular nanovesicle-coated LNPs (M1-C-LNPs), specifically engineered combined gene-immunotherapy approach against solid tumor. The...
In response to the coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2), global efforts are focused on development of new therapeutic interventions. For treatment COVID-19, selective lung-localizing strategies hold tremendous potential, as SARS-CoV-2 invades lung via ACE2 receptors and causes pneumonia. Similarly, recent reports have shown association COVID-19 with decreased 25-hydroxycholesterol (25-HC) increased cytokine levels. This...
Productivity and sialylation are two important factors for the production of recombinant glycoproteins in mammalian cell culture. In our previous study, we found that silkworm hemolymph increased secreted human placental alkaline phosphatase insect cells, promoted transfer sialic acids onto glycoprotein oligosaccharides an vitro asialofetuin system, enhanced protein Chinese hamster ovary (CHO) cells. These beneficial effects were mainly due to 30K proteins, which consist five isoforms. Among...
The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as disease 2019 (COVID-19), has posed a serious threat to public health across globe, calling for development effective diagnostic markers therapeutics. Here, we report reliable severity biomarker, acetylated 676th lysine transforming growth factor-beta-induced protein (TGFBIp K676Ac). TGFBIp K676Ac was consistently elevated in blood patients with SARS-CoV-2 pneumonia (n...