A5030651682- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Kawasaki Disease and Coronary Complications
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- SARS-CoV-2 and COVID-19 Research
- Aortic Disease and Treatment Approaches
- Pharmacovigilance and Adverse Drug Reactions
- Silk-based biomaterials and applications
- Cardiovascular Issues in Pregnancy
- Cardiovascular Disease and Adiposity
- Thyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Bone Tissue Engineering Materials
- Vascular anomalies and interventions
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Viral Infections and Immunology Research
- Graphene and Nanomaterials Applications
- Metabolism and Genetic Disorders
- Magnetic Bearings and Levitation Dynamics
- Polymer Surface Interaction Studies
Yonsei University
2015-2025
Severance Hospital
2015-2023
Yonsei University Health System
2018-2020
Korea Electric Power Corporation (South Korea)
2008-2009
Abstract Environmental pollution arising from plastic waste is a major global concern. Plastic macroparticles, microparticles, and nanoparticles have the potential to affect marine ecosystems human health. It generally accepted that microplastic particles are not harmful or at best minimal However direct contact with may possible adverse effect in cellular level. Primary polystyrene (PS) were focus of this study, we investigated impacts these microplastics on health We determined PS immune...
Abstract Aims The clinical manifestation and outcomes of thrombosis with thrombocytopenia syndrome (TTS) after adenoviral COVID-19 vaccine administration are largely unknown due to the rare nature disease. We aimed analyse presentation, treatment modalities, outcomes, prognostic factors TTS, as well identify predictors for mortality. Methods Results PubMed, Scopus, Embase, Web Science databases were searched resulting articles reviewed. A total 6 case series 13 reports (64 patients) TTS...
Two messenger RNA (mRNA) vaccines developed by Pfizer-BioNTech and Moderna are being rolled out. Despite the high volume of emerging evidence regarding adverse events (AEs) associated with COVID-19 mRNA vaccines, previous studies have thus far been largely based on comparison between vaccinated unvaccinated control, possibly highlighting AE risks vaccination. Comparing safety profile individuals otherwise would enable a more relevant assessment for We designed comparative study 18 755 27 895...
Abstract On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as first drug for treatment of coronavirus disease 2019 (COVID‐19), increasing prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remain unknown. We aimed to characterize CV adverse reactions (ADRs) using VigiBase, an individual case safety report database World Health Organization (WHO). Disproportionality analyses CV‐ADRs were performed reported odds ratios...
<h3>Importance</h3> Infections are proposed to be triggering factors for Kawasaki disease (KD), although its etiological remain unknown. Recent reports have indicated a 4- 6-week lag between SARS-CoV-2 infection and multisystem inflammatory syndrome in children with similar presentation that of KD. <h3>Objective</h3> To investigate the temporal correlation KD viral infections, focusing on respiratory viruses. <h3>Design, Setting, Participants</h3> This cohort study was conducted among...
This study demonstrates the possibility of developing a rapidly degradable chitosan-based multilayer film for controlled drug release. The chitosan (CHI)-based nanofilms were prepared with three different types anions, hyaluronic acid (HA), alginic (ALG) and tannic (TA). Taking advantage Layer-by-Layer (LBL) assembly, each has morphology, porosity thickness depending on their ionic density, molecular structure polymer functionality building blocks. We loaded models such as doxorubicin...
During the coronavirus disease 2019 (COVID-19) outbreak, prevalence of obesity increased globally; this may be associated with hypertension incidence. However, investigations on changes in among children and adolescents are limited. This cross-sectional study investigated 1428 youths aged 10-18 years using data from Korea National Health Nutrition Examination Survey 2018-2020. We assessed according to sex, age, body mass index (BMI), residential district. The 7.1% 12.5% all participants. In...
Pulmonary arterial hypertension (PAH) related to an atrial septal defect (ASD) poses a challenge transcatheter closure of ASD (tcASD). We aimed determine the predictors for remaining PAH (rPAH) post-tcASD. This retrospective study was conducted at single tertiary university hospital. Adult patients with and were divided into three groups according pulmonary vascular resistance (PVR). Normalization systolic pressure (PASP) defined as estimated right ventricular < 40 mmHg determined using...
Abstract Bioprosthetic valves are employed to replace defective heart valves. However, structural degeneration is prevalent in bioprosthetic because the valve leaflets exposed extreme and repetitive cardiovascular pressure. Herein, a silk fibroin‐based leaflet, which executes physiological role of valve, developed. To this end, templated assembly technology Notably, physically optimal hierarchical structure for replacing natural leaflet realized by numerous firmly stacked β‐sheet crystals...
Abstract Background Methimazole (MMI) and propylthiouracil (PTU) are commonly used for patients with thyrotoxicosis. Agranulocytosis antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) is associated high morbidity mortality, requiring appropriate interventions. In this study, we compared adverse drug effects MMI PTU using a real‐world large pharmacovigilance database. Methods We searched all Individual Case Safety Reports reported to be PTU, from VigiBase between 1967 June...
The Liesegang pattern is a beautiful natural anisotropic patterning phenomenon observed in rocks and sandstones. This study reveals that the can induce nonlinear elasticity. Here, Liesegang-patterned complex with biomineral-hydrogel repetitive layers prepared. obtained only when biomineralization performed under supersaturated conditions. features elastic response, whereas single biomineral shell shows linear behavior, thus demonstrating essential achieving stiff have buffered concentrated...
Medical plastic-appliance-based healthcare services, especially in dentistry, generate tremendous amounts of plastic waste. Given the physiological features our mouth, it is desirable to substitute dental care plastics with viscoelastic and antimicrobial bioplastics. Herein, we develop a medical-grade sustainable bioplastic that enough align tooth positions, resists microbial contamination, exhibits recyclable life cycles. In particular, devise molecular template involving...
Cell-based protein sources are considered promising future food materials due to their nutritional potential and sustainability. However, the process of massive cell proliferation, which involves an expensive culture medium is time-consuming, slows development cell-based foods. Herein, we report on cost-effective media prepared from egg whites, microalgae, silk extracts. The developed showed proliferation efficiency similar that conventional group while maintaining bovine myoblasts in...
The clinical outcome of children with severe acute myocarditis who require mechanical circulatory support is not well known. Therefore, we studied the survival and courses patients fulminant supported by extracorporeal life (ECLS).We performed a retrospective chart review 13 consecutive were treated ECLS between April 2013 2015. Demographics, initial symptoms, laboratory results, management, last follow-up status investigated.The median age was 25.8 months (range, 2.9 to 11.5 years) body...
Percutaneous pulmonary valve implantation (PPVI) is used to treat stenosis (PS) or regurgitation (PR). We described our experience with PPVI, specifically valve-in-valve transcatheter replacement using the Melody and novel self-expandable systems Pulsta valve. reviewed data from 42 patients undergoing PPVI. Twenty-nine had valves in mostly bioprosthetic valves, valved conduits, homografts position. Following implantation, peak right ventricle-to-pulmonary artery gradient decreased 51.3 ±...