Florian Marks
A5006942560- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Child Nutrition and Water Access
- Malaria Research and Control
- Bacterial Identification and Susceptibility Testing
- Global Maternal and Child Health
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- Hepatitis Viruses Studies and Epidemiology
- Fecal contamination and water quality
- Viral Infections and Outbreaks Research
- Vector-borne infectious diseases
- Zoonotic diseases and public health
- Clostridium difficile and Clostridium perfringens research
- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Leptospirosis research and findings
International Vaccine Institute
2016-2025
University of Cambridge
2017-2025
University of Antananarivo
2018-2025
Heidelberg University
2022-2025
University Hospital Heidelberg
2022-2025
Université de Mahajanga
2024
Cambridge Consultants (United Kingdom)
2024
Hong Kong Jockey Club
2024
Institute for Health Metrics and Evaluation
2019-2023
University of Washington
2019-2023
Upcoming vaccination efforts against typhoid fever require an assessment of the baseline burden disease in countries at risk. There are no incidence data from most low- and middle-income (LMICs), so model-based estimates offer insights for decision-makers absence readily available data.We developed a mixed-effects model fit to 32 population-based studies 22 locations 14 countries. We tested contribution economic environmental indices predicting using stochastic search variable selection...
Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry required to better understand the nature and burden of Africa. We aimed measure adjusted estimates typhoid fever non-typhoidal (iNTS) Africa, antimicrobial susceptibility profiles causative agents.We established a systematic, standardised surveillance blood culture-based febrile illness 13 African sentinel sites with previous reports fever: Burkina Faso (two sites), Ethiopia,...
The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) nearly 2,000 isolates sourced over 60 countries generate a robust genotyping scheme that is phylogenetically informative and compatible with range assays. These show that, exception rapidly disseminating H58 subclade (now...
Southeast Asia, a vibrant region that has recently undergone unprecedented economic development, is regarded as global hotspot for the emergence and spread of antimicrobial resistance (AMR). Understanding AMR in Asia crucial assessing how to control on an international scale. Here we (i) describe current situation (ii) explore mechanisms make focal AMR, (iii) propose ways which could contribute solution.
A critical and persistent challenge to global health modern care is the threat of antimicrobial resistance (AMR). Previous studies have reported a disproportionate burden AMR in low-income middle-income countries, but there remains an urgent need for more in-depth analyses across Africa. This study presents one most comprehensive sets regional country-level estimates bacterial WHO African region date.
<h2>Summary</h2><h3>Background</h3> Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Africa programme was designed to address regional gaps typhoid burden data identify populations eligible for interventions using novel conjugate vaccines. <h3>Methods</h3> A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, implemented six countries sub-Saharan Africa. Patients presenting fever...
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction whole genome sequenced 249 contemporaneous S. isolated between 2008-2015 11 African countries, context 2,057 global genomic framework. Despite broad genetic diversity, majority organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), 2.3.2...
Background The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, part, due suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites Nigeria have identified associated with Salmonella enterica serovar Typhi (S. Typhi) as an important cause bacteremia children. Methods A total 128 S. isolates from these studies were whole-genome sequenced, and the resulting data was used place Nigerian into a worldwide context based on their...
Abstract As whole-genome sequencing capacity becomes increasingly decentralized, there is a growing opportunity for collaboration and the sharing of surveillance data within between countries to inform typhoid control policies. This vision requires free, community-driven tools that facilitate access genomic public health on global scale. Here we present Pathogenwatch scheme Salmonella enterica serovar Typhi ( S . Typhi), web application enabling rapid identification markers antimicrobial...
Vaccines against Japanese encephalitis (JE) have been available for decades. Currently, most JE-endemic countries vaccination programs their at-risk populations. Even so, JE remains the leading recognized cause of viral in Asia. In 2018, U.S. Centers Disease Control and Prevention PATH co-convened a group independent experts to review prevention control successes, identify remaining scientific operational issues that need be addressed, discuss opportunities further strengthen programs,...
Precise enteric fever disease burden data are needed to inform prevention and control measures, including the use of newly available typhoid vaccines. We established Surveillance for Enteric Fever in Asia Project (SEAP) these strategies.
BackgroundThe incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim this study was to evaluate whether new diagnostic serological markers for Salmonella can reliably estimate population-level incidence.MethodsWe collected longitudinal samples from patients with culture-confirmed fever enrolled surveillance studies Bangladesh,...
Enteric fever, a systemic infection caused by Salmonella enterica serovars Typhi and Paratyphi A, remains major cause of morbidity mortality in low-income middle-income countries. fever is preventable through the provision clean water adequate sanitation can be successfully treated with antibiotics. However, high levels antimicrobial resistance (AMR) compromise effectiveness treatment. We provide estimates prevalence AMR S A 75 endemic countries, including 30 locations without data.
The objective of the study was to describe systemic bacterial infections occurring in acutely ill and hospitalized children a rural region Ghana, regarding frequency, incidence, antimicrobial susceptibility patterns associations with anthropometrical data. Blood cultures were performed all below age five years, who admitted Agogo Presbyterian Hospital (APH), Asante Region, between September 2007 July 2009. Medical history data assessed using standardized questionnaire at admission....
Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children HIV-infected adults sub-Saharan Africa. In contrast, the epidemiology clinical manifestations iNTS disease Asia not well documented. We retrospectively identified >100 cases an infectious hospital Southern Vietnam between 2008 2013. Clinical records were accessed to evaluate demographic factors associated with infection identify risk death. Multi-locus sequence typing...