A5069552324- Burkholderia infections and melioidosis
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Parasitic Infections and Diagnostics
- Vector-borne infectious diseases
- Amoebic Infections and Treatments
- Parasites and Host Interactions
- Infective Endocarditis Diagnosis and Management
- Brucella: diagnosis, epidemiology, treatment
- Antimicrobial Resistance in Staphylococcus
- Malaria Research and Control
- Mosquito-borne diseases and control
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Child Nutrition and Water Access
- Streptococcal Infections and Treatments
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Travel-related health issues
- Vibrio bacteria research studies
- Escherichia coli research studies
- Hepatitis B Virus Studies
- Clostridium difficile and Clostridium perfringens research
Bundeswehrzentralkrankenhaus Koblenz
2020-2025
University Hospital Bonn
2024-2025
Bundeswehrkrankenhaus
2011-2022
St. George's University
2020
Bundeswehr Medical Service Academy
2001-2019
Bernhard Nocht Institute for Tropical Medicine
2008-2018
North Atlantic Treaty Organization
2016-2017
Armed Forces Hospital
2013-2016
Institut für Mikrobiologie der Bundeswehr
2002-2006
Czech Academy of Sciences, Institute of Microbiology
2005-2006
The objective of the study was to describe systemic bacterial infections occurring in acutely ill and hospitalized children a rural region Ghana, regarding frequency, incidence, antimicrobial susceptibility patterns associations with anthropometrical data. Blood cultures were performed all below age five years, who admitted Agogo Presbyterian Hospital (APH), Asante Region, between September 2007 July 2009. Medical history data assessed using standardized questionnaire at admission....
Introduction Diarrheal diseases are among the most frequent causes of morbidity and mortality in children worldwide, especially resource-poor areas. This case-control study assessed associations between gastrointestinal infections diarrhea from rural Ghana. Methods Stool samples were collected 548 with 686 without symptoms visiting a hospital 2007–2008. Samples analyzed by microscopy molecular methods. Results The organisms frequently detected symptomatic cases Giardia lamblia, Shigella...
Abstract Background. Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated (CDAD) are common complications of antibiotic use. Data on the efficacy probiotics to prevent AAD CDAD unclear. We aimed evaluate Saccharomyces boulardii in hospitalized adult patients. Methods. conducted a multicenter, phase III, double-masked, randomized, placebo-controlled trial patients who received systemic treatment 15 hospitals Germany between July 2010 October 2012. Participants Perenterol...
Background The relevance of Cryptosporidium infections for the burden childhood diarrhoea in endemic settings has been shown recent years. This study describes subtypes among symptomatic and asymptomatic children rural Ghana to analyse subtype-specific demographic, geographical, seasonal clinical differences order inform appropriate control measures areas. Methodology/Principal Findings Stool samples were collected from 2232 below 14 years age presenting with without gastrointestinal...
Background: Molecular methods, in particular PCR, are increasingly used for the diagnosis of enteric pathogens stool samples. In high-endemicity settings, however, asymptomatic carriage or residual DNA from previous infections will hamper interpretation positive test results. We assessed quantitative dimension this problem schoolchildren rural highlands Madagascar. Methods: Stool samples were collected 410 apparently healthy Madagascan and analysed by multiplex real-time PCR enteroinvasive...
The SARS-CoV-2 infection can be seen as a single disease, but it also affects patients with relevant comorbidities who may have an increased risk of severe course infection. In this report, we present 77-year-old patient heart transplant receiving immunosuppressive therapy tested positive for after several days dyspnea, dry cough, and light general symptoms. Computed tomography confirmed interstitial pneumonia. received antiviral hydroxychloroquine showed no further deterioration the...
At the Bundeswehr Hospitals of Hamburg and Westerstede, patients repatriated from subtropical war crisis zones Northern Africa Middle East were medically treated, including microbiological assessment. Within a six-year interval, 16 Acinetobacter spp. strains, 14 baumannii (Ab) isolates with resistance against carbapenems origins in Afghanistan (n = 4), Iraq 2), Libya Syria 8) collected. While clonal relationships Libyan Syrian strains had been assessed by superficial next generation...
Background: The number of skin conductance fluctuations (NSCF) expresses sympathetic nerve activity. response entropy (RE) measures electromyographic and electroencephalographic activity in the forehead. state (SE) mainly When suppression frontal muscular is complete, RE equal to SE. RE‐Δ defined as SE minus RE. purposes this study were examine whether NSCF correlate with signs clinical stress during intubation tetanic noxious stimulation elucidate how rapidly accurately react emergence from...
Due to considerable differences in pathogenicity, Haemophilus influenzae, H. parainfluenzae and haemolyticus have be reliably discriminated routine diagnostics. Retrospective analyses suggest frequent misidentifications of commensal as influenzae. In a multi-center approach, we assessed the suitability fluorescence situ hybridization (FISH) matrix-assisted laser-desorption-ionization time-of-flight mass-spectrometry (MALDI-TOF-MS) for identification species level.A strain collection 84 spp....
Introduction. Since 2013, European soldiers have been deployed on the Union Training Mission (EUTM) in Mali. From beginning, diarrhea has among most "urgent" concerns. Diarrhea surveillance based deployable real-time PCR equipment was conducted between December 2013 and August 2014. Material Methods. In total, 53 stool samples were obtained from 51 with acute diarrhea. Multiplex panels comprised enteroinvasive bacteria, diarrhea-associated Escherichia coli (EPEC, ETEC, EAEC, EIEC),...
Methicillin-resistant Staphylococcus aureus (MRSA) clones pose a significant threat to hospitalised patients because the bacteria can be transmitted by asymptomatic carriers within healthcare facilities. To date, nothing is known about prevalence of S. and MRSA among workers in Madagascar. The objective our study was examine clonal epidemiology nasal non-medical University students Antananarivo, This cross sectional screened swabs taken from for aureus. Multiplex PCR performed identify...
Recently, a total of 32 carbapenem- and fluoroquinolone-resistant Acinetobacter baumannii (Ab) isolates was isolated from war-injured patients who were treated at German Bundeswehr Hospitals, preliminarily typed by "DiversiLab" repetitive elements sequence-based (rep-) PCR. Core genome-based sequence typing also used to provide more detailed epidemiological information. From the clusters observed rep-PCR, selected Ab strains subjected Next Generation Sequencing (NGS) in order compare them...
Antimicrobial resistance is a global threat to safe health care, and reduction in antibiotic consumption seems be an appropriate preventive measure. In Germany, the reporting of hospital antibiotics independent institution only voluntary. Although high level willingness improve can assumed case participation, median consumptions hospitals change slightly. This study examines question whether logistical figures adequately reflect real consumption, if not, how optimize use data for clinical...
Information on the molecular epidemiology and carbapenem resistance mechanisms in Gram-negative bacterial isolates Moldova is scarce. To close this knowledge gap, carbapenem-resistant bacteria were collected over an 11-month period a routine diagnostic laboratory Moldova. Antimicrobial susceptibility was phenotypically genotypically assessed. Phylogenetic relationships investigated multi-locus sequence types provided. The assessment indicated several clusters of phylogenetically closely...
In the three consecutive years of 2022–2024, female specimens phlebotomine sandfly Phlebotomus mascittii were trapped in two locations vicinity Coblenz, western Germany. These records slightly expand distribution limits species Federal State Rhineland-Palatinate to north, at latitudes 50°18'N and 50°15'N, respectively, represent second northernmost Palearctic so far.
The diagnosis and antimicrobial treatment of pneumonia in African children the absence diagnostic means such as x-ray facilities or microbiological laboratories relies primarily on clinical symptoms presented by patients. In order to assess spectrum bacterial pathogens, blood cultures were performed fulfilling criteria pneumonia. total, 1032 taken from between 2 months 5 years age who admitted a rural hospital Ghana September 2007 July 2009. Pneumonia was diagnosed clinically according WHO...
Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however mode transmission and source invasive NTS Africa are poorly understood. This study compares from water sources rural Ghana. Blood hospitalised, febrile children samples drinking were analysed for spp. Strains serotyped to trace possible epidemiological links between human water-derived isolates.. Antibiotic susceptibility testing was performed, In 2720 blood culture samples, 165 (6%) isolated. S....
Introduction . The aim of the study was evaluation panfungal PCR protocols with subsequent sequence analysis for diagnostic identification invasive mycoses in formalin-fixed, paraffin-embedded tissue samples rare tropical mycoses. Materials and Methods Five different previously described PCR/sequencing targeting 18S 28S ribosomal RNA gene fragments as well internal transcribed spacer 1 2 were evaluated a collection 17 patients and/or mycoses, comprising chromoblastomycosis,...
The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples patients with invasive fungal infections and amebiasis was investigated. Samples chromoblastomycosis (n = 3), coccidioidomycosis 2), histoplasmosis 4), or cryptococcosis poor histological discriminability 1), mucormycosis mycetoma rhinosporidiosis Entamoeba histolytica 6) were analyzed by NGS (each one Illumina v3 run...